2,3-difluoro-4-vinylphenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3-difluoro-4-vinylphenol
• 英文别名: 2,3-difluoro-4-hydroxy-styrene；4-ethenyl-2,3-difluorophenol
• 化学式: C₈H₆F₂O
• 分子量: 156.132
• InChiKey: UCBGDYNJUOJESM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,3-二氟苯酚 、 sodium pyruvate 在 ferulic acid decarboxylase from Enterobacter spharoides 、 recombinant tyrosine phenol lyase M₃₇₉V from Citrobacter freundii 、 tyrosine ammonia lyase from Rhodobacter spharoides 、 氯化铵 作用下， 以 aq. phosphate buffer 、 乙醚 为溶剂， 反应 24.0h， 以65%的产率得到2,3-difluoro-4-vinylphenol
  参考文献：
  名称：

  使用生物催化系统乙烯基化未保护的苯酚

  摘要：

  在大气条件下，将易于获得的取代酚与丙酮酸盐在缓冲溶液中偶联，以提供相应的对乙烯基苯酚衍生物，同时仅释放一分子的CO 2和水作为副产物。这种转化是通过设计一种生物催化系统来实现的，该系统结合了三个生物催化步骤，即在氨气存在下苯酚和丙酮酸的CC偶联，生成相应的酪氨酸衍生物，然后进行脱氨和脱羧。生物催化转化以高区域选择性进行，仅提供所需的对位产品。因此，该方法代表了一种环境友好的方法，可直接以制备规模（0.5 mmol）直接将2-，3-或2,3-二取代的苯酚乙烯基化，从而以高收率（65-83％）提供乙烯基苯酚。

  DOI：

  10.1002/anie.201505696

文献信息

• [EN] 2,3-DIHYDROIMIDAZO[1,2-C] PYRIMIDIN-5(1H)-ONE COMPOUNDS USE AS LP-PLA2 INHIBITORS<br/>[FR] COMPOSÉS 2,3-DIHYDROIMIDAZO[1,2-C]PYRIMIDIN-5(1H)-ONE ET UTILISATION EN TANT QU'INHIBITEURS DE LP-PLA2
  申请人：GLAXO GROUP LTD

  公开号：WO2013013503A1

  公开（公告）日：2013-01-31

  Disclosed are 2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one compounds that inhibit Lp-PLA2, processes for their preparation, compositions containing them and their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.

  本文披露了抑制Lp-PLA2的2,3-二氢咪唑[1,2-c]嘧啶-5(1H)-酮化合物，以及其制备方法、含有它们的组合物以及它们在治疗与Lp-PLA2活性相关的疾病中的用途，例如动脉粥样硬化、阿尔茨海默病。
• Acid-degradable resin compositions containing ketene-aldehyde copolymer
  申请人：Sudo Atsushi

  公开号：US20050130057A1

  公开（公告）日：2005-06-16

  It is intended to provide compositions to be used in resists and the like for forming fine patterns with a high sensitivity and a high resolution by increasing the difference in the solubilities between exposed parts and unexposed parts. Acid-degradable compositions contain a polymer having a repeating unit represented by the following general formula (I): wherein R 1 and R 2 independently represent hydrogen atom, halogen atom, C 1-20 hydrocarbon group, a heterocyclic group, a cyano group, a nitro group, C(═O)R 4 group, S(O) n R 4 group, P(═O)(R 4 ) 2 group or M(R 4 ) 3 group; R 3 represents C 1-20 hydrocarbon group or a heterocyclic group: R 4 represents C 1-20 hydrocarbonoxy group, C 1-20 hydrocarbon group, C 1-20 hydrocarbonthio group or mono- or di-C 1-20 hydrocarbonamino group; M represents a silicon, germanium, tin or lead atom; and n is 0, 1 or 2 , and an acid or a compound capable of generating an acid in response to an external stimulus.

  本发明旨在提供用于制备高灵敏度和高分辨率细微图案的抗蚀剂等组合物，通过增加曝光部分和未曝光部分之间的溶解度差异。可降解酸性组合物包含具有以下通式（I）所表示的重复单元的聚合物：其中，R1和R2独立地表示氢原子、卤素原子、C1-20碳氢基团、杂环基团、氰基团、硝基团、C（═O）R4基团、S（O）nR4基团、P（═O）（R4）2基团或M（R4）3基团；R3表示C1-20碳氢基团或杂环基团；R4表示C1-20碳氢氧基团、C1-20碳氢基团、C1-20碳氢硫基团或单烷基或二烷基氨基基团；M表示硅、锗、锡或铅原子；n为0、1或2，以及一种酸或能够响应外部刺激产生酸的化合物。
• ACID-DEGRADABLE RESIN COMPOSITIONS CONTAINING KETENE-ALDEHYDE COPOLYMER
  申请人：NIPPON SODA CO., LTD.

  公开号：EP1482361A1

  公开（公告）日：2004-12-01

  It is intended to provide compositions to be used in resists and the like for forming fine patterns with a high sensitivity and a high resolution by increasing the difference in the solubilities between exposed parts and unexposed parts. Acid-degradable compositions contain a polymer having a repeating unit represented by the following general formula (I): wherein R1 and R2 independently represent hydrogen atom, halogen atom, C1-20 hydrocarbon group, a heterocyclic group, a cyano group, a nitro group, C(=O)R4 group, S(O)nR4 group, P(=O)(R4)2 group or M(R4)3 group; R3 represents C1-20 hydrocarbon group or a heterocyclic group: R4 represents C1-20 hydrocarbonoxy group, C1-20 hydrocarbon group, C1-20 hydrocarbonthio group or mono- or di- C1-20 hydrocarbonamino group; M represents a silicon, germanium, tin or lead atom; and n is 0, 1 or 2, and an acid or a compound capable of generating an acid in response to an external stimulus.

  本发明旨在提供用于抗蚀剂等的组合物，通过增大暴露部分和未暴露部分之间的溶解度差异，形成具有高灵敏度和高分辨率的精细图案。可酸性降解组合物含有一种聚合物，其重复单元由以下通式 (I) 表示： 其中 R1 和 R2 分别代表氢原子、卤素原子、C1-20 烃基、杂环基、氰基、硝基、C(＝O)R4 基、S(O)nR4 基、P(＝O)(R4)2 基或 M(R4)3 基；R3 代表 C1-20 烃基或杂环基：R4代表C1-20烃氧基、C1-20烃基、C1-20烃硫基或单-或双-C1-20烃氨基；M代表硅、锗、锡或铅原子；n为0、1或2。
• FLUORINE-CONTAINING CROSSLINKABLE ELASTOMER COMPOSITION AND CROSSLINKED PRODUCT THEREOF
  申请人：Asahi Glass Company, Limited

  公开号：EP3031856A1

  公开（公告）日：2016-06-15

  To provide a crosslinkable fluorinated elastomer composition which is excellent in crosslinking reactivity and of which a crosslinked product is excellent in heat resistance and chemical resistance. The crosslinkable fluorinated elastomer composition comprises a fluorinated elastomer (e.g. a tetrafluoroethylene/perfluoro(alkyl vinyl ether) copolymer) and an aromatic compound having at least two crosslinkable unsaturated double bonds (e.g. a compound represented by the formula (A-1)), and the crosslinked product is one obtained by crosslinking the crosslinkable fluorinated elastomer composition.

  提供一种可交联含氟弹性体组合物，该组合物具有优异的交联反应性，其交联产品具有优异的耐热性和耐化学性。可交联含氟弹性体组合物由含氟弹性体（例如四氟乙烯/全氟（烷基乙烯基醚）共聚物）和至少具有两个可交联不饱和双键的芳香族化合物（例如由式（A-1）表示的化合物）组成，交联产物是通过交联该可交联含氟弹性体组合物获得的。
• BIO-ELECTRODE COMPOSITION, BIO-ELECTRODE, METHOD FOR MANUFACTURING BIOELECTRODE, AND REACTION COMPOSITE
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP3995548A1

  公开（公告）日：2022-05-11

  A bio-electrode composition contains (A) a reaction composite of an ionic polymer material and a carbon particle. The component (A) contains the carbon particle bonding to the polymer containing a repeating unit having a structure selected from the group consisting of salts of ammonium, lithium, sodium, potassium, and silver formed with any of fluorosulfonic acid, fluorosulfonimide, and N-carbonyl-fluorosulfonamide. Thus, the present invention provides: a bio-electrode composition capable of forming a living body contact layer for a bio-electrode which is excellent in electric conductivity and biocompatibility, light-weight, and manufacturable at low cost, and which prevents significant reduction in the electric conductivity even when wetted with water or dried; a bio-electrode including a living body contact layer formed of the bio-electrode composition; and a method for manufacturing the bio-electrode.

  一种生物电极组合物包含（A）离子聚合物材料和碳颗粒的反应复合材料。组分（A）包含碳颗粒，碳颗粒与聚合物结合，聚合物含有重复单元，该重复单元的结构选自由铵盐、锂盐、钠盐、钾盐和银盐组成的组，这些盐与氟磺酸、氟磺酰亚胺和 N-羰基-氟磺酰胺中的任意一种形成。因此，本发明提供了：一种能够为生物电极形成活体接触层的生物电极组合物，其导电性和生物相容性极佳，重量轻，可低成本制造，即使被水浸湿或干燥，也不会显著降低导电性；一种生物电极，包括由该生物电极组合物形成的活体接触层；以及一种制造该生物电极的方法。