methyl 4-(ethoxymethoxy)benzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 4-(ethoxymethoxy)benzoate
• 化学式: C₁₁H₁₄O₄
• 分子量: 210.23
• InChiKey: UXIFNZKNFDACNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

上下游信息

• 上游原料

  中文名称	英文名称	CAS号	化学式	分子量
  对羟基苯甲酸甲酯	methyl 4-hydroxybenzoate	99-76-3	C8H8O3	152.15

反应信息

• 作为反应物：
  描述：

  methyl 4-(ethoxymethoxy)benzoate 在 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 以62%的产率得到4-(ethoxymethoxy)benzoic acid
  参考文献：
  名称：

  4-Alkyliden-azetidinones modified with plant derived polyphenols: Antibacterial and antioxidant properties

  摘要：

  Antimicrobial resistance is one of the major and growing concerns in hospital-and community acquired infections, and new antimicrobial agents are therefore urgently required. It was reported that oxidative stress could contribute to the selection of resistant bacterial strains, since reactive oxygen species (ROS) revealed to be an essential driving force. In the present work 4-allcylidene-azetidinones, a new class of antibacterial agents, were functionalized with phytochemical polyphenolic acids such as protocatechuic, piperonyl, caffeic, ferulic, or sinapic acids and investigated as dual target antibacterial-antioxidant compounds. The best candidates showed good activities against multidrug resistant clinical isolates of MRSA (MICs 2-8 mu g/mL). Among the new compounds, two revealed the best antioxidant capacity with TEAC-DPPH and TEAC-ABTS being significantly more active than Troloxe. (C) 2017 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2017.09.048
• 作为产物：
  描述：

  对羟基苯甲酸甲酯 、 氯甲基乙醚 在 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 2.17h， 以91%的产率得到methyl 4-(ethoxymethoxy)benzoate
  参考文献：
  名称：

  4-Alkyliden-azetidinones modified with plant derived polyphenols: Antibacterial and antioxidant properties

  摘要：

  Antimicrobial resistance is one of the major and growing concerns in hospital-and community acquired infections, and new antimicrobial agents are therefore urgently required. It was reported that oxidative stress could contribute to the selection of resistant bacterial strains, since reactive oxygen species (ROS) revealed to be an essential driving force. In the present work 4-allcylidene-azetidinones, a new class of antibacterial agents, were functionalized with phytochemical polyphenolic acids such as protocatechuic, piperonyl, caffeic, ferulic, or sinapic acids and investigated as dual target antibacterial-antioxidant compounds. The best candidates showed good activities against multidrug resistant clinical isolates of MRSA (MICs 2-8 mu g/mL). Among the new compounds, two revealed the best antioxidant capacity with TEAC-DPPH and TEAC-ABTS being significantly more active than Troloxe. (C) 2017 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2017.09.048

文献信息

• 4-Alkyliden-azetidinones modified with plant derived polyphenols: Antibacterial and antioxidant properties
  作者：Daria Giacomini、Rosario Musumeci、Paola Galletti、Giulia Martelli、Lorenzo Assennato、Gianni Sacchetti、Alessandra Guerrini、Enrico Calaresu、Marianna Martinelli、Clementina Cocuzza

  DOI：10.1016/j.ejmech.2017.09.048

  日期：2017.11

  Antimicrobial resistance is one of the major and growing concerns in hospital-and community acquired infections, and new antimicrobial agents are therefore urgently required. It was reported that oxidative stress could contribute to the selection of resistant bacterial strains, since reactive oxygen species (ROS) revealed to be an essential driving force. In the present work 4-allcylidene-azetidinones, a new class of antibacterial agents, were functionalized with phytochemical polyphenolic acids such as protocatechuic, piperonyl, caffeic, ferulic, or sinapic acids and investigated as dual target antibacterial-antioxidant compounds. The best candidates showed good activities against multidrug resistant clinical isolates of MRSA (MICs 2-8 mu g/mL). Among the new compounds, two revealed the best antioxidant capacity with TEAC-DPPH and TEAC-ABTS being significantly more active than Troloxe. (C) 2017 Elsevier Masson SAS. All rights reserved.