乳清酸锌 | 60388-02-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 乳清酸锌
• 英文名称: zinc;2,4-dioxo-1H-pyrimidine-6-carboxylic acid;2-oxido-6-oxo-1H-pyrimidine-4-carboxylate
• CAS: 60388-02-5
• 化学式: C10H6N4O8Zn
• 分子量: 375.6
• InChiKey: YNMDOZLVAPMCBD-UHFFFAOYSA-L

物化性质

• LogP：
  -0.928 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  -5.15
• 重原子数：
  23
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  197
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• [EN] ANTI-INFECTIVE AND ANTI-VIRAL COMPOUNDS AND COMPOSITIONS<br/>[FR] COMPOSÉS ANTI-INFECTIEUX ET ANTIVIRAUX, ET COMPOSITIONS
  申请人：BURNET MICHAEL W

  公开号：WO2021195126A1

  公开（公告）日：2021-09-30

  Lysosomally accumulated substances that release a nitroxy group, or a short chain fatty acid or a product of anaerobic metabolism or a thiol or a sulfide often from an ester or similar labile linkage have anti-inflammatory, anti-cancer and anti-bacterial activity. They are useful in treating infectious, inflammatory and malignant disease and are immune stimulatory, promote zinc uptake, disable endosomal reactions and synergise anti-viral action of protease inhibitors. The compounds are useful for the treatment of bacterial, viral and mixed pneumonias.

  溶酶体积累的物质，能释放硝基氧基团、短链脂肪酸、厌氧代谢产物、硫醇或硫化物，常来自酯或类似不稳定键合，具有抗炎、抗癌和抗菌活性。它们在治疗感染性、炎症性和恶性疾病方面有用，能刺激免疫、促进锌吸收、抑制内体反应并增强蛋白酶抑制剂的抗病毒作用。这些化合物可用于治疗细菌性、病毒性和混合性肺炎。
• [EN] COSMECEUTICAL COMPOSITION<br/>[FR] COMPOSITION COSMÉCEUTIQUE
  申请人：TRIM EDICINE INC

  公开号：WO2021150383A1

  公开（公告）日：2021-07-29

  Cosmeceutical compositions for and methods of improving the appearance of skin and promoting hair growth are provided. Said compositions comprise at least one ROS-scavenging polymer gel, at least MG53, or a combination thereof. A novel boronate ester- based copolymer forms an aqueous hydrogel exhibiting lower viscosity at cooler temperatures and higher viscosity at higher temperatures is provided.

  提供了一种用于改善皮肤外观和促进头发生长的化妆品组合物和方法。所述组合物包括至少一种ROS清除聚合物凝胶，至少MG53，或其组合物。提供了一种新型的硼酸酯基共聚物形成水性水凝胶，在较低温度下具有较低的粘度，在较高温度下具有较高的粘度。
• [EN] ZINC COMPOUND AND CYCLODEXTRINE FOR TREATMENT OF GASTRIC DISORDERS<br/>[FR] COMPOSE DE ZINC ET CYCLODEXTRINE UTILISES DANS LE TRAITEMENT DES TROUBLES GASTRIQUES
  申请人：BELLARA MEDICAL PRODUCTS LIMITED

  公开号：WO1995025513A1

  公开（公告）日：1995-09-28

  (EN) A pharmaceutical composition and a method for the treatment of gastric disorders and $i(Helicobacter pylori) in the stomach or duodenum comprising a zinc compound and a cyclodextrin or cyclodextrin derivative for instance selected from $g(a)-cyclodextrin, $g(b)-cyclodextrin or $g(g)-cyclodextrin. The pharmaceutical composition may also include a pharmaceutically acceptable acidic compound such as a carboxylic acid.(FR) L'invention se rapporte à une composition pharmaceutique et à un procédé destinés au traitement des troubles gastriques et dus à la présence d'$i(Hélicobacter pylori) dans l'estomac ou le duodénum, ladite composition comprenant un composé de zinc et une cyclodextrine ou un dérivé de cyclodextrine, par exemple, la cyclodextrine étant sélectionnée parmi la cyclodextrine $g(a), la cyclodextrine $g(b) ou la cyclodextrine $g(g). La composition pharmaceutique peut également comprendre un composé acide pharmaceutiquement acceptable, tel qu'un acide carboxylique.

  一种药物组合物和治疗胃部疾病和胃或十二指肠中的幽门螺杆菌的方法，包括一种锌化合物和一种环糊精或环糊精衍生物，例如选择自α-环糊精、β-环糊精或γ-环糊精。该药物组合物还可以包括一种药学上可接受的酸性化合物，例如羧酸。
• Therapeutic or preventing agent for the diseases caused by a decrease in the expression level of the klotho protein
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1327443A1

  公开（公告）日：2003-07-16

  The present invention provides a therapeutic or preventing agent for diseases caused by a decrease in the expression level of Klotho protein in animals or humans and a feed or food and drink for the treatment or prevention of such diseases, which comprise ornithine or a salt thereof as an active ingredient. Also provided are a therapeutic or preventing agent for premature aging-like syndrome of homozygous klotho mutant animals and a feed for the treatment or prevention of the syndrome, which comprise ornithine or a salt thereof as an active ingredient, as well as a method for the treatment or prevention of premature aging-like syndrome of homozygous klotho mutant animals which comprises feeding the animals with the above feed.

  本发明提供了一种治疗或预防因动物或人类 Klotho 蛋白表达水平下降而引起的疾病的药物，以及一种治疗或预防此类疾病的饲料或食品和饮料，其中包含鸟氨酸或其盐作为活性成分。此外，还提供了一种治疗或预防同源Klotho突变动物早衰综合征的药物和一种治疗或预防该综合征的饲料，其活性成分包括鸟氨酸或其盐，以及一种治疗或预防同源Klotho突变动物早衰综合征的方法，该方法包括用上述饲料喂养动物。
• ANTIINFLAMMATORIC AND ANTITUSSIVE COMPOSITIONS
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1402892A1

  公开（公告）日：2004-03-31

  The object of the present invention is to provide antiinflammatory agents for airway, foods and drinks, animal feeds, food additives, feed additives and a method for preventing or treating airway inflammations. The object is achieved by providing antiinflammatory agents for airway, foods and drinks, animal feeds, food additives and feed additives, each comprising, as the active ingredient thereof, orotic acid or its derivative or a salt thereof; and a method for preventing or treating airway inflammations which comprises administering orotic acid or its derivative or a salt thereof.

  本发明的目的是提供用于气道、食品和饮料、动物饲料、食品添加剂、饲料添加剂的抗炎剂以及预防或治疗气道炎症的方法。本发明的目的是通过提供用于气道、食品和饮料、动物饲料、食品添加剂和饲料添加剂的抗炎剂来实现的，每种抗炎剂都包含作为其活性成分的奥罗酸或其衍生物或其盐；以及一种预防或治疗气道炎症的方法，该方法包括施用奥罗酸或其衍生物或其盐。