二(4-氯苄基)二异丙基氨基磷酸酯 | 128858-43-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 二(4-氯苄基)二异丙基氨基磷酸酯
• 英文名称: bis(4-chlorobenzyl) N,N-diisopropylphosphorodiamidite
• 英文别名: N,N-Diisopropyl-bis(4-chlorobenzyl)phosphoramidite；bis(4-chlorobenzyl)-N,N-diisopropylphosphoramidite；Bis(p-chlorobenzyloxy)(diisopropylamino)phosphine；N,N-diisopropylbis(4-chlorobenzyl)phosphoramidite；di(4-chlorobenzyl)N,N-diisopropylphosphoramidite；Di-p-chlorobenzyl N,N-Diisopropylphosphoramidite；N-[bis[(4-chlorophenyl)methoxy]phosphanyl]-N-propan-2-ylpropan-2-amine
• CAS: 128858-43-5
• 化学式: C₂₀H₂₆Cl₂NO₂P
• 分子量: 414.312
• InChiKey: OCQXCPQSBNWTOF-UHFFFAOYSA-N

物化性质

• 溶解度：
  氯仿（微溶）、甲醇（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  二(4-氯苄基)二异丙基氨基磷酸酯 在 四氮唑 、 间氯过氧苯甲酸 作用下， 以 乙腈 为溶剂， 反应 2.0h， 生成 methyl (2S)-3-[4-[bis[(4-chlorophenyl)methoxy]phosphoryloxy]phenyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
  参考文献：
  名称：

  Bont, H. B. A. de; Boom, J. H. van; Liskamp, R. M. J., Recueil des Travaux Chimiques des Pays-Bas, 1990, vol. 109, # 1, p. 27 - 28

  摘要：

  DOI：
• 作为产物：
  描述：

  二氯-N,N-二异丙基亚磷酰胺 、 4-氯苯甲醇 在 三乙胺 作用下， 以 乙醚 为溶剂， 反应 2.0h， 以61%的产率得到二(4-氯苄基)二异丙基氨基磷酸酯
  参考文献：
  名称：

  Perich, John W.; Johns, R. B., Australian Journal of Chemistry, 1991, vol. 44, # 3, p. 389 - 396

  摘要：

  DOI：

文献信息

• Cyclic phosphopeptides for interference with Grb2 SH2 domain signal transduction prepared by ring-closing metathesis and phosphorylation
  作者：Frank J. Dekker、Nico J. de Mol、Marcel J. E. Fischer、Johan Kemmink、Rob M. J. Liskamp

  DOI：10.1039/b306681a

  日期：——

  prepared using ring-closing metathesis followed by phosphorylation. These cyclic phosphopeptides were designed to interact with the SH2 domain of Grb2, which is a signal transduction protein of importance as a target for antiproliferative drug development. Binding of these peptides to the Grb2 SH2 domain was evaluated by a surface plasmon resonance assay. High affinity binding to the Grb2 SH2 domain was

  使用闭环易位然后进行磷酸化来制备环状磷酸肽。这些环状磷酸肽被设计为与Grb2的SH2结构域相互作用，Grb2是一种信号转导蛋白，作为抗增殖药物开发的靶标具有重要意义。通过表面等离振子共振测定法评估这些肽与Grb2 SH2结构域的结合。大环化后，与Grb2 SH2域的高亲和力结合得以维持，因此表明该方法可用于组装干扰信号转导级联反应的高亲和力环状磷酸肽。
• Synthesis of D-2-deoxy-myo-inositol 1,3,4,5-tetrakisphosphate from D-glucose
  作者：David J. Jenkins、Didier Dubreuil、Barry V. L. Potter

  DOI：10.1039/p19960001365

  日期：——

  protection of methyl α-D-glucopyranoside and subsequent catalytic Ferrier rearrangement to a deoxyinosose. Thus, methyl α-D-glucopyranoside was converted by an improved procedure into methyl 4,6-O-benzylidene-α-D-glucopyranoside 4 and thence into methyl 3-O-benzoyl-2-O-benzyl-4,6-O-benzylidene-α-D-glucopyranoside 7 without recourse to column chromatography. Compound 7 was converted into methyl 3,4-di-O

  一种新的路由，结构改性d -肌醇肌醇1,3,4,5-四磷酸盐类似物，d -2-脱氧肌肌醇1,3,4,5-四磷酸盐3，描述，涉及作为关键步骤是对甲基α- D-吡喃葡萄糖苷进行选择性保护，随后催化Ferrier重排为脱氧肌苷。因此，甲基α- d吡喃葡萄糖苷被转化通过改进的过程成甲基4,6- ø -亚苄基- α- d吡喃葡萄糖苷4，然后进入3- ø -苯甲酰基-2- ø -苄基-4,6- O-亚苄基-α- D-吡喃葡萄糖苷7，无需柱色谱法。化合物7转化成甲基3,4-二- ø -苯甲酰基-2- ö苄基-6-脱氧α- d -木糖-己-5-烯吡喃糖苷12经由甲基3,4-二- ö -benzoyl- 2 - O-苄基-6-溴-6-脱氧-α- D-吡喃葡萄糖苷8.用三氟乙酸汞（II）重整烯醇醚12 （2 S，3 R，4 S，5 R）-2,3 -二苯甲酰氧基-4-苄氧基-5-羟基环己酮13和（2 S，3 R，4
• Monoclonal antibodies specific PHF-TAU, hybridomas secreting them, antigen recognition by these antibodies and their applications
  申请人：Innogenetics N.V.

  公开号：US20030138972A1

  公开（公告）日：2003-07-24

  A peptide from 6 to 100 amino acids long, including an amino acid sequence depicted by one of a) Val-Arg-Thr-Pro-Pro (amino acid 229-233; human tau numbering, SEQ ID NO 2) wherein the peptide is able to form an immunological complex with the monoclonal antibody AT180 produced by the hybridoma deposited at the ECACC on Dec. 22, 1992 under No.92122204 and b) Pro-Lys-Thr-Pro-Pro (amino acid 179-183; human tau numbering, SEQ ID NO 3) wherein the peptide is able to form an immunological complex with the monoclonal antibody AT270 produced by the hybridoma deposited at the ECACC on Jul. 7,1993 under No.93070774, with Thr being phosphorylated. A method of detecting PHF-tau protein one of the peptides is also disclosed.

  长度为 6 至 100 个氨基酸的多肽，包括以下氨基酸序列之一 a) Val-Arg-Thr-Pro-Pro（氨基酸 229-233；人类 tau 编号，SEQ ID NO 2），其中该多肽能够与 1992 年 12 月 22 日以 92122204 号在 ECACC 登记的杂交瘤产生的单克隆抗体 AT180 形成免疫复合物；以及 b) Pro-Lys-Thr-Pro-Pro（氨基酸 179-183；人类 tau 编号，SEQ ID NO 3），其中该多肽能够与 1992 年 12 月 22 日以 92122204 号在 ECACC 登记的杂交瘤产生的单克隆抗体 AT180 形成免疫复合物。和 b）Pro-Lys-Thr-Pro-Pro（氨基酸 179-183；人类 tau 编号，SEQ ID NO 3），其中该多肽能与 1993 年 7 月 7 日以 93070774 号存于 ECACC 的杂交瘤产生的单克隆抗体 AT270 形成免疫复合物，Thr 被磷酸化。此外，还公开了一种检测其中一种肽的 PHF-tau 蛋白的方法。
• Monoclonal antibodies specific for PHF-TAU, hybridomas secreting them, antigen recognition by these antibodies and their applications
  申请人：Innogenetics N.V.

  公开号：US20040038430A1

  公开（公告）日：2004-02-26

  The present invention relates more particularly to a monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to abnormally phosphorylated tau (PHF-tau) residing in the region spanning positions (143-254), and with said monoclonal antibody being characterized by the fact that it is capable of specifically detecting abnormally phosphorylated tau protein (PHF-tau) in cerebrospinal fluid (CSF).

  本发明尤其涉及一种单克隆抗体，它能与位于跨位置（143-254）区域的异常磷酸化 tau（PHF-tau）抗原的磷酸化表位形成免疫复合物，所述单克隆抗体的特点是能够特异性检测脑脊液（CSF）中的异常磷酸化 tau 蛋白（PHF-tau）。
• Syntheses of Amino Acid Based Phosphodiester Linkage-Containing Cryptands as well as Diphosphorylated Macrocycles
  作者：Anita H. van Oijen、Nina P. M. Huck、John A. W. Kruijtzer、Cees Erkelens、Jacques H. van Boom、Rob M. J. Liskamp

  DOI：10.1021/jo00088a022

  日期：1994.5

  The synthesis of two amino acid based phosphodiester linkage-containing cryptands (30 and 44) as well as diphosphorylated macrocycles (28, 29, 32 and 33) are described. Boc-L-Ser(Bn)-OH and/or Boc-D-Ser(Bn)-OH were used for the construction of the construction of the precursors for the diphosphitylation and marcocyclization by phosphitylation. The carboxylic acid groups were connected with a diethylene glycol unit and the amino functionalities were linked using (ethylenedioxy)diacetic acid, oxydiacetic acid, or an isophthalic acid derivative. The LD-cryptands 30 and 44 were obtained after phosphitylation of the precursors 12 and 16, respectively, containing (ethylenedixoy)acetic acid or an isophthalic acid derivative as a bottom-spacer, using 4-chlorobenzyl phosphorodichlorodite followed by oxidation and hydrogenolysis. Phosphitylation of the precursors containing (ethylenedioxy)acetic acid or oxydiacetic acid as bottom-spacers 11-14, using bis(4-chlorobenzyl) N,N-diisopropylphosphoramidite and subsequent oxidation resulted in the corresponding diphosphorylated macrocycles 28, 29, 32, and 33.