二(4-氯苯基)磷氯化酸酯 | 15074-53-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 二(4-氯苯基)磷氯化酸酯
• 英文名称: bis(4-chlorophenyl)phosphoryl chloride
• 英文别名: di(p-chlorophenyl) chlorophosphate；di(p-chlorophenyl) chlorophosphonate；chlorophosphoric acid bis-(4-chloro-phenyl ester)；Chlorophosphorsaeure-bis-(4-chlor-phenylester)；(4-Chlor-phenyl)-chlorophosphat；Phosphorsaeure-bis-(4-chlor-phenyl)-ester-chlorid；bis(4-chlorophenyl) phosphorochloridate；di-p-chlorophenylphosphorochloridate；1-chloro-4-[chloro-(4-chlorophenoxy)phosphoryl]oxybenzene
• CAS: 15074-53-0
• 化学式: C₁₂H₈Cl₃O₃P
• 分子量: 337.526
• InChiKey: PMGATFZDMDTJKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  二(4-氯苯基)磷氯化酸酯 在 水 作用下， 以 丙酮 为溶剂， 反应 1.0h， 以8.8 g的产率得到bis-(4-chlorophenyl)phosphoric acid
  参考文献：
  名称：

  Neodymium tris-diarylphosphates: Systematic study of the structure–reactivity relationship in butadiene and isoprene polymerisation

  摘要：

  The catalytic properties of neodymium tris-phosphates with various diarylphosphate ligands in the stereoregular 1,4-cis-polymerisation of butadiene and isoprene were studied. The considerable variability of the diaryl phosphate structure allowed for the systematic investigation of the dependence of the catalytic properties of neodymium tris-diarylphosphates on the electronic and steric properties of the ligand. Electron-withdrawing substituents (F, Cl, Br) in the aryl moiety increased the catalyst activity of tris-diarylphosphate. Neodymium aryl phosphates containing lipophilic bulky ligands provided the synthesis of polydienes with a monomodal molecular-weight distribution. The optimal catalytic properties demonstrated that the neodymium aryl phosphate prepared from bis(2,6-dimethy1-4-tert-butylpheny1)phosphoric acid showed high activity and ensured a monomodal MWD of polydienes (M-w/M-n similar to 2 for polybutadiene and M-w/M-n similar to 3 for polyisoprene) in various conditions. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.apcata.2014.04.007
• 作为产物：
  描述：

  对氯苯酚 在 magnesium chloride 、 三氯氧磷 作用下， 反应 24.0h， 生成 二(4-氯苯基)磷氯化酸酯
  参考文献：
  名称：

  锌催化的二芳基磷酰基叠氮化物向二芳基磷酸酯和酰胺的转化。

  摘要：

  我们已经开发了一种简便而有效的合成二芳基磷酸酯和酰胺的方法。使用Zn（acac）2作为催化剂，二芳基磷酰基叠氮化物与脂肪族醇和苯酚的反应通过不寻常的PN键裂解，以良好的收率提供了许多二芳基磷酸酯（22个实例，最高94％）。另外，从相应的胺也以优异的产率获得了各种二芳基磷酸酰胺（8个实例，高达96％）。

  DOI：

  10.1002/asia.202000154

文献信息

• 一种具有杀线虫活性的四唑磷酸酯化合物及 合成方法
  申请人：安徽农业大学

  公开号：CN106083929B

  公开（公告）日：2017-12-15

  本发明涉及一种具有杀线虫活性的四唑磷酸酯化合物。所述四唑磷酸酯化合物的化学式如通式Ⅰ所示：式Ⅰ中，R1为1‑6个碳原子的烷基或苯基或苄基或卤代苯基或卤代苄基；R2为氢原子或乙酸酯基或苯基或苄基或卤代苯基或卤代苄基；式Ⅰ中，羟甲基的位置为1位或者2位。生物测定实验结果表明此类四唑磷酸酯化合物在50mg/L浓度下，对水稻潜根线虫、小麦孢囊线虫和葡萄寄生线虫24小时的校正死亡率在65‑94％，具有很好的杀线虫活性。
• 2'-deoxy-5-fluorouridine derivatives
  申请人：Kuraray Co., Ltd.

  公开号：US05032680A1

  公开（公告）日：1991-07-16

  2'-Deoxy-5-fluorouridine derivatives of the formula ##STR1## wherein, R.sup.1 is hydrogen atom or an acyl group and R.sup.2 and R.sup.3 are respectively hydrogen atom, an acyl group or a group of the formula ##STR2## wherein X.sup.1 and X.sup.2 are respectively oxygen atom or sulfur atom; R.sup.4 is a phenyl group, a benzyl group or a naphthyl group each of which may be substituted by an alkyl group, an alkoxyl group, an alkoxycarbonyl group, an alkylthio group, and acyl group, a halogen atom, trifluoromethyl group, nitro group, cyano group, carboxyl group and/or methylenedioxy group and R.sup.5 is an alkyl group, an alkenyl group or one of the groups represented by R.sup.4 which is the same as or different from R.sup.4, at least one of R.sup.2 and R.sup.3 being a group of the formula ##STR3## which exhibit excellent antitumour activities and have lower toxicity, methods of the production thereof and antitumour compositions containing said 2'-deoxy-5-fluorouridine derivatives.

  2'-脱氧-5-氟尿苷衍生物的化学式为##STR1##其中，R.sup.1是氢原子或酰基，R.sup.2和R.sup.3分别是氢原子，酰基或化学式##STR2##中的基团，其中X.sup.1和X.sup.2分别是氧原子或硫原子；R.sup.4是苯基，苄基或萘基，每个基团都可以被烷基，烷氧基，烷氧羰基，烷硫基，酰基，卤素原子，三氟甲基基团，硝基，氰基，羧基和/或亚甲氧基取代，R.sup.5是烷基，烯基或由R.sup.4表示的基团之一，与R.sup.4相同或不同，R.sup.2和R.sup.3中至少有一个是化学式##STR3##的基团，这些衍生物表现出优异的抗肿瘤活性，毒性较低，制备方法和含有所述2'-脱氧-5-氟尿苷衍生物的抗肿瘤组合物。
• New guanosine derivatives: facile O6-phosphorylation, thiophosphinylation sulfonylation and silylation of guanosine derivatives by 4-dimethylaminopyridine catalized reaction
  作者：Hristo Petrov Daskalov、Mitsuo Sekine、Tsujiaki Hata

  DOI：10.1016/0040-4039(80)80211-5

  日期：1980.1

  Appropriately protected guanosine derivatives were successfully converted to the corresponding O6-substituted guanosine derivatives by treatment with dialkyl- or diaryl-phosphoryl halides, dialkyl- or diaryl-phosphinothioyl halides, arenesulfonyl chlorides, and trialkylsilyl chlorides.

  通过用二烷基或二芳基-磷酰卤，二烷基或二芳基-膦硫酰卤，芳烃磺酰氯和三烷基甲硅烷基氯处理，将适当保护的鸟苷衍生物成功转化为相应的O 6取代的鸟苷衍生物。
• ANTI-CYTOMEGALOVIRUS ACTIVITY OF ARTEMISININ-DERIVED DIMERS
  申请人：Arav-Boger Ravit

  公开号：US20130109654A1

  公开（公告）日：2013-05-02

  Artemisinin-derived monomers and artemisinin dimers are shown to exhibit in-vitro anti-cytomegalovirus (CMV) activity. Artemisinin dimers effectively inhibited CMV replication in human foreskin fibroblasts and human embryonic lung fibroblasts with no cytotoxicity at concentrations required for complete CMV inhibition. Artemisinin dimers were found to be potent and non-cytotoxic inhibitors of CMV replication, which indicates their use as therapeutic agents for the treatment of CMV infection in humans.

  青蒿素衍生单体和青蒿素二聚体表现出体外抗巨细胞病毒（CMV）活性。青蒿素二聚体有效抑制了人阴茎包皮纤维细胞和人胚肺纤维细胞中的CMV复制，且在完全抑制CMV所需的浓度下无细胞毒性。青蒿素二聚体被发现是强效且无细胞毒性的CMV复制抑制剂，这表明它们可用作治疗人类CMV感染的治疗剂。
• Eight‐Membered Palladacycle Intermediate Enabled Synthesis of Cyclic Biarylphosphonates
  作者：Xin‐Xin Yang、Ming‐Ying Wu、Shao‐Qiu Wang、Shang‐Dong Yang

  DOI：10.1002/chem.202302416

  日期：2024.1.11

  palladium-catalyzed intramolecular C−H bond arylation of triarylphosphonate is reported to access cyclic biarylphosphonates targets. The reaction is achieved via an unique eight-membered palladacycle intermediate and show good functional group compatibility under mild reaction condition.

  过渡金属催化的偶联反应涉及插入 C−H 键的直接官能化，是最有效的碳-碳键形成策略之一。据报道，钯催化的三芳基膦酸酯的分子内CH键芳基化可以获得环状二芳基膦酸酯目标。该反应通过独特的八元环钯中间体实现，在温和的反应条件下表现出良好的官能团相容性。