4-bromo-2-nitro-benzaldehyde-oxime

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-bromo-2-nitro-benzaldehyde-oxime
• 英文别名: 4-Brom-2-nitro-benzaldehyd-oxim；4-Brom-2-nitro-benzaldoxim；4-Bromo-2-nitro-(phenylmethylene)azanol；(NE)-N-[(4-bromo-2-nitrophenyl)methylidene]hydroxylamine
• 化学式: C₇H₅BrN₂O₃
• 分子量: 245.032
• InChiKey: ZLTOIUHNPLXEBN-RUDMXATFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-bromo-2-nitro-benzaldehyde-oxime 在 iron (III)-ammonium sulfate 、 硫酸 作用下， 生成 4-溴-2-硝基苯甲醛
  参考文献：
  名称：

  Functional hyperandrogenism detected by corticotropin and GnRH-analogue stimulation tests in women affected by apparently idiopathic hirsutism

  摘要：

  The etiologic diagnosis of hirsutism is often difficult. Previous studies have reported normal basal androgen and SHBG concentrations in 33-50% of hirsute women, suggesting the presence of an "idiopathic" form of hirsutism as the most frequent cause of this problem. The recent use of GnRH-analogues together with the corticotropin stimulation test allows better understanding of whether the cause of hirsutism is androgen excess and, if so, whether the origin of the latter is ovarian, adrenal or both. The present study evaluated adrenal and ovarian function in 48 young hirsute women as well as in 78 normal women matched for body mass index and age, who acted as control group. To determine ovarian function, a single 100-mug dose of GnRH analogue triptorelin was injected sc; thereafter, gonadotropins, 17-hydroxyprogesterone (17-OHP), Delta4-androstenedione (Delta4), total testosterone (T) and estradiol were determined. To better understand the adrenal function, 250 mug of 1,24 ACTH were administrated as iv infusion for 5 h, and plasma cortisol (F), 17-OHP, Delta4, DHEAS, T, 11-desossicortisol were measured. The combined use of these two stimulation tests was able to detect mild to moderate abnormalities in the steroidogenesis of ovaries alone (23%), adrenals alone (16.6%), or both (35.4%) in most hirsute women (75%) with otherwise normal baseline androgen concentrations. In particular, patients showed significantly increased responses of 17-OHP, Delta4, total T, 11-desossicortisol, and F to 1,24-ACTH administration. Moreover, they also had significantly higher 17-OHP and T responses to triptorelin. In conclusion, milder forms of functional ovarian and/or adrenal hyperandrogenism, similar to those found in clearly hyperandrogenic women, were observed and could be an underlying mechanism of idiopathic hirsutism. (J. Endocrinol. Invest. 24: 491-498, 2001) (C) 2001, Editrice Kurtis.

  DOI：

  10.1007/bf03343881
• 作为产物：
  描述：

  4-溴-2-硝基苯甲醛 在 乙醇 、 羟胺 作用下， 生成 4-bromo-2-nitro-benzaldehyde-oxime
  参考文献：
  名称：

  Sachs; Sichel, Chemische Berichte, 1904, vol. 37, p. 1873

  摘要：

  DOI：

文献信息

• Gabriel; Meyer, Chemische Berichte, 1881, vol. 14, p. 830
  作者：Gabriel、Meyer

  DOI：——

  日期：——
• Mueller,J., Chemische Berichte, 1909, vol. 42, p. 3697
  作者：Mueller,J.

  DOI：——

  日期：——
• Rottig, Journal fur praktische Chemie (Leipzig 1954), 1935, vol. <2> 142, p. 35
  作者：Rottig

  DOI：——

  日期：——
• Functional hyperandrogenism detected by corticotropin and GnRH-analogue stimulation tests in women affected by apparently idiopathic hirsutism
  作者：Riccardo Rossi、L. Tauchmanovà、A. Luciano、R. Valentino、S. Savastano、C. Battista、M. Di Martino、G. Lombardi

  DOI：10.1007/bf03343881

  日期：2001.7

  The etiologic diagnosis of hirsutism is often difficult. Previous studies have reported normal basal androgen and SHBG concentrations in 33-50% of hirsute women, suggesting the presence of an "idiopathic" form of hirsutism as the most frequent cause of this problem. The recent use of GnRH-analogues together with the corticotropin stimulation test allows better understanding of whether the cause of hirsutism is androgen excess and, if so, whether the origin of the latter is ovarian, adrenal or both. The present study evaluated adrenal and ovarian function in 48 young hirsute women as well as in 78 normal women matched for body mass index and age, who acted as control group. To determine ovarian function, a single 100-mug dose of GnRH analogue triptorelin was injected sc; thereafter, gonadotropins, 17-hydroxyprogesterone (17-OHP), Delta4-androstenedione (Delta4), total testosterone (T) and estradiol were determined. To better understand the adrenal function, 250 mug of 1,24 ACTH were administrated as iv infusion for 5 h, and plasma cortisol (F), 17-OHP, Delta4, DHEAS, T, 11-desossicortisol were measured. The combined use of these two stimulation tests was able to detect mild to moderate abnormalities in the steroidogenesis of ovaries alone (23%), adrenals alone (16.6%), or both (35.4%) in most hirsute women (75%) with otherwise normal baseline androgen concentrations. In particular, patients showed significantly increased responses of 17-OHP, Delta4, total T, 11-desossicortisol, and F to 1,24-ACTH administration. Moreover, they also had significantly higher 17-OHP and T responses to triptorelin. In conclusion, milder forms of functional ovarian and/or adrenal hyperandrogenism, similar to those found in clearly hyperandrogenic women, were observed and could be an underlying mechanism of idiopathic hirsutism. (J. Endocrinol. Invest. 24: 491-498, 2001) (C) 2001, Editrice Kurtis.
• Sachs; Sichel, Chemische Berichte, 1904, vol. 37, p. 1873
  作者：Sachs、Sichel

  DOI：——

  日期：——