二(4-磺基丁基)醚二钠

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 中文名称: 二(4-磺基丁基)醚二钠
• 中文别名: 双(4 - 磺丁基)醚二钠
• 英文名称: disodium;4-(4-sulfonatobutoxy)butane-1-sulfonate
• 化学式: C8H16Na2O7S2
• 分子量: 334.3
• InChiKey: FMASHOOOLPDQTK-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -6.34
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  140
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• MANUFACTURING PROCESS FOR CYCLODEXTRIN DERIVATIVES
  申请人：CYDEX PHARMACEUTICALS, INC.

  公开号：US20160009826A1

  公开（公告）日：2016-01-14

  A process and equipment assembly for reacting a substituent precursor with a cyclodextrin starting material to provide a raw product comprising a cyclodextrin derivative and 1% or less of an initial amount of the substituent precursor is provided, The process of the present invention provides cyclodextrin derivatives in substantially shorter time and with fewer side products than previous processes that utilize substantially the same starting materials.

  提供一种用于将取代基前体物与环糊精起始材料反应以提供原材料的过程和设备组装，该原材料包括环糊精衍生物和不到取代基前体物初始量1％的量。本发明的过程比使用基本相同起始材料的以前的过程更快地提供环糊精衍生物，并且副产物更少。
• Sulfoalkyl Ether Cyclodextrin Compositions
  申请人：ANTLE Vincent

  公开号：US20090270348A1

  公开（公告）日：2009-10-29

  SAE-CD compositions are provided, along with methods of making and using the same. The SAE-CD composition comprises a sulfoalkyl ether cyclodextrin and less than 100 ppm of a phosphate, wherein the SAE-CD composition has an absorption of less than 0.5 A.U. due to a drug-degrading agent, as determined by UV/vis spectrophotometry at a wavelength of 245 nm to 270 nm for an aqueous solution containing 300 mg of the SAE-CD composition per mL of solution in a cell having a 1 cm path length.

  提供了SAE-CD组合物，以及制备和使用该组合物的方法。SAE-CD组合物包括一种磺醚基环糊精和少于100 ppm的磷酸盐，其中SAE-CD组合物由于药物降解剂的存在，在含有每毫升300毫克SAE-CD组合物的水溶液中，通过245 nm至270 nm波长的UV / vis分光光度计测定，其吸收度小于0.5 A.U.。
• Alkylated cyclodextrin compositions and processes for preparing and using the same
  申请人：CyDex Pharmaceuticals, Inc.

  公开号：US10040872B2

  公开（公告）日：2018-08-07

  The present invention related to low-chloride alkylated cyclodextrin compositions, along with processes for preparing and using the same. The processes of the present invention provide alkylated cyclodextrins with low levels of drug-degrading agents and chloride.

  本发明涉及低氯化物烷基化环糊精组合物，以及制备和使用这种组合物的工艺。本发明的工艺提供了药物降解剂和氯化物含量较低的烷基化环糊精。
• Sulfoalkyl ether cyclodextrin compositions
  申请人：CyDex Pharmaceuticals, Inc.

  公开号：US10117951B2

  公开（公告）日：2018-11-06

  SAE-CD compositions are provided, along with methods of making and using the same. The SAE-CD compositions comprise a sulfoalkyl ether cyclodextrin having an absorption of less than 0.5 A.U. due to a drug-degrading agent, as determined by UV/vis spectrophotometry at a wavelength of 245 nm to 270 nm for an aqueous solution containing 300 mg of the SAE-CD composition per mL of solution in a cell having a 1 cm path length.

  提供了 SAE-CD 组合物及其制造和使用方法。SAE-CD 组合物包含一种磺基烷基醚环糊精，在波长为 245 纳米至 270 纳米的波长下，对每毫升含有 300 毫克 SAE-CD 组合物的水溶液进行紫外/可见分光光度法测定，其药物降解剂吸收率小于 0.5 A.U.。
• Manufacturing process for cyclodextrin derivatives
  申请人：CyDex Pharmaceuticals, Inc.

  公开号：US10633462B2

  公开（公告）日：2020-04-28

  A process and equipment assembly for reacting a substituent precursor with a cyclodextrin starting material to provide a raw product comprising a cyclodextrin derivative and 1% or less of an initial amount of the substituent precursor is provided. The process of the present invention provides cyclodextrin derivatives in substantially shorter time and with fewer side products than previous processes that utilize substantially the same starting materials.

  本发明提供了一种工艺和设备组件，用于将取代基前体与环糊精起始原料反应，以提供一种原料产品，该产品包括环糊精衍生物和 1%或更少初始量的取代基前体。与以前使用基本相同的起始原料的工艺相比，本发明的工艺提供环糊精衍生物的时间大大缩短，副产品也更少。