[EN] NOVEL SELECTIVE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 [FR] NOUVEAUX INHIBITEURS SÉLECTIFS DE LA 11-BÊTA-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE DE TYPE 1
[EN] BIARYL PYRAZOLES AS NRF2 REGULATORS<br/>[FR] BIARYL PYRAZOLES UTILISÉS COMME RÉGULATEURS DE NRF2
申请人:GLAXOSMITHKLINE IP DEV LTD
公开号:WO2017060854A1
公开(公告)日:2017-04-13
The present invention relates to biaryl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
本发明涉及双芳基吡唑化合物、它们的制备方法、含有它们的药物组合物及其作为NRF2调节剂的应用。
Palladium-Catalyzed Aminocarbonylation of<i>N</i>-Chloroamines with Boronic Acids
作者:Wanfang Li、Xiao-Feng Wu
DOI:10.1002/chem.201500779
日期:2015.5.11
synthetic points of view, the carbonylative transformation of NX bonds represents an interesting and attractive area of investigation. In light of this, the first carbonylative cross‐coupling between N‐chloroamines and organoboronic acids has been developed. This new type of aminocarbonylation proceeds at mild temperatures (45–55 °C) with 2 mol % Pd/C (10 wt %) as the ligand‐free catalyst. Not only arylboronic
申请人:GlaxoSmithKline Intellectual Property Development Limited
公开号:US10364256B2
公开(公告)日:2019-07-30
The present invention relates to biaryl pyrazole compounds of Formula (I)
methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.
Selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
申请人:DSM IP ASSETS B.V.
公开号:US10550097B2
公开(公告)日:2020-02-04
The present invention relates to novel selective 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and the use thereof to prevent age-induced skin structure and function defects.