bis-(2-tetrahydrofurfuryloxy-ethyl)-ether

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: bis-(2-tetrahydrofurfuryloxy-ethyl)-ether
• 英文别名: Bis-(2-tetrahydrofurfuryloxy-aethyl)-aether；2-[2-[2-(Oxolan-2-ylmethoxy)ethoxy]ethoxymethyl]oxolane
• 化学式: C₁₄H₂₆O₅
• 分子量: 274.357
• InChiKey: CUHZTZOTJHZBMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  四氢糠醇 、 1,2-二溴乙烷 在 lithium 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 反应 4.0h， 以243.7g的产率得到bis-(2-tetrahydrofurfuryloxy-ethyl)-ether
  参考文献：
  名称：

  乙二撑双四氢糠醇醚的合成方法及应用

  摘要：

  本发明公开了一种乙二撑双四氢糠醇醚的合成方法及其应用，乙二撑双四氢糠醇醚的制备方法是将四氢糠醇先和碱金属，或碱金属碱反应，再和1,2‑二卤代乙烷反应，反应完成后，过滤，将过滤所得滤液蒸馏，即得；该方法流程和操作简单，合成的乙二撑双四氢糠醇醚产率高、纯度高，将其作为结构调节剂和活化剂可高效调节共轭二烯阴离子聚合产物中1,2或3,4加成物的百分含量。

  公开号：

  CN105218491B

文献信息

• [EN] AN IMPROVED PROCESS FOR THE PREPARATION OF APREMILAST AND ITS INTERMEDIATE<br/>[FR] PROCÉDÉ AMÉLIORÉ DE PRÉPARATION D'APRÉMILAST ET DE SON INTERMÉDIAIRE
  申请人：PIRAMAL ENTPR LTD

  公开号：WO2019073431A1

  公开（公告）日：2019-04-18

  The present invention provides an improved process for preparation of pure N-(2-(l-(3- ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-l,3-dioxoisoindolin-4-yl)acetamide (1) (commonly known as Apremilast); wherein the content of des-acetyl apremilast (la) is less than 1% w/w and having total amount of genotoxic substances less than 25 ppm; comprising the steps of reacting the compound l-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan- 1-amine (A) or its chiral acid salt with N-(l,3-dioxo-l,3-dihydroisobenzofuran-4-yl)-acetamide (B) in presence of ether or amide solvent and optionally, in presence of an acid; followed by the treatment with an acetylating agent.

  本发明提供了一种改进的制备纯N-(2-(1-(3-乙氧基-4-甲氧基苯基)-2-(甲磺酰基)乙基)-1,3-二氧杂异吲哚-4-基)乙酰胺（通常称为阿普利马斯特）的过程；其中去乙酰阿普利马斯特的含量小于1% w/w，且具有总基因毒性物质少于25 ppm；包括以下步骤：在醚或酰胺溶剂的存在下，将化合物1-(3-乙氧基-4-甲氧基苯基)-2-(甲磺酰基)乙基胺（A）或其手性酸盐与N-(1,3-二氧-1,3-二氢异苯并呋喃-4-基)-乙酰胺（B）反应，可选地，在酸的存在下；然后用乙酰化剂处理。
• OXYGEN ABSORBING COMPOSITION AND CONTAINERS MADE BY USING THE SAME
  申请人：Kuraray Co., Ltd.

  公开号：EP1930073A1

  公开（公告）日：2008-06-11

  An oxygen absorbing composition of the present invention comprises a compound with a molecular weight of less than 10000 and an oxygen absorption accelerator. The compound includes two or more ring structures that are of at least one type, each of which has an ether bond. The oxygen absorbing composition further may contain a gas barrier resin. A laminate of the present invention comprises a layer formed of an oxygen absorbing composition of the present invention.

  本发明的吸氧组合物由分子量小于 10000 的化合物和吸氧促进剂组成。该化合物包括至少一种类型的两个或多个环结构，每个环结构都有一个醚键。吸氧组合物还可含有气体阻隔树脂。本发明的层压板包括由本发明的吸氧组合物形成的层。
• Genetics of Fracture: Challenges and Opportunities
  作者：Tuan V. Nguyen、John A. Eisman

  DOI：10.1359/jbmr.2000.15.7.1253

  日期：——
• Curable composition, ink composition, inkjet recording method, printer matter, method for producing planographic printing plate, planographic printing plate and oxetane compound
  申请人：Watanabe Kotaro

  公开号：US20070112088A1

  公开（公告）日：2007-05-17

  According to the present invention, provided are a curable composition containing a (A) compound which has a structure having two or more cyclic ether groups, in the molecule and a linking group linking the cyclic ether groups, which contains an alkylene group having 4 or more carbon atoms, or a curable composition containing a compound which has, in the molecule, two or more moiety structures containing 4-membered or more cyclic ether and a moiety structure represented by the following formula (Y-I), and an ink composition comprising the curable composition and a compound represented by the following formula (i).
• US6130195A
  申请人：——

  公开号：US6130195A

  公开（公告）日：2000-10-10