trans-5-methoxydecursidinol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: trans-5-methoxydecursidinol
• 英文别名: (3R,4S)-3,4-dihydroxy-5-methoxy-2,2-dimethyl-3,4-dihydropyrano[3,2-g]chromen-8-one
• 化学式: C₁₅H₁₆O₆
• 分子量: 292.288
• InChiKey: WZJQHBPPISFUSP-GXTWGEPZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  85.2
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  黄木亭 在 Amberlyst-15 (H⁺) resin 、 水 、 二甲基二环氧乙烷 作用下， 以 丙酮 为溶剂， 反应 1.5h， 生成 trans-5-methoxydecursidinol
  参考文献：
  名称：

  Natural Product-like Combinatorial Libraries Based on Privileged Structures. 3. The “Libraries from Libraries” Principle for Diversity Enhancement of Benzopyran Libraries

  摘要：

  As described in the preceding two papers, our interest in the construction of natural and natural product-like libraries for chemical biology studies led to the development of a new solid-phase cycloloading strategy for the construction of substituted benzopyrans. Herein, we report a parallel solution-phase method that facilitates the enhancement of both the size and diversity of these non-oligomeric benzopyran libraries using the "libraries from libraries" principle. We examine the rationale behind the use of this tandem strategy to construct discrete small molecule libraries, and describe the development of a polymer-assisted solution-phase (PASP) methodology necessary to effect the required transformations. Once developed, this chemistry is applied to two demonstration libraries.

  DOI：

  10.1021/ja0020355

文献信息

• Constituents of Domestic Citrus Plants. Part XVI. Five New Pyranocoumarins from Some Citrus Plants.
  作者：Yuko TAKEMURA、Yumiko NAKATA、Miki AZUMA、Motoharu JU-ICHI、Masayoshi OKANO、Narihiko FUKAMIYA、Mitsuo OMURA、Chihiro ITO、Kiyomi NAKAGAWA、Hiroshi FURUKAWA

  DOI：10.1248/cpb.41.1530

  日期：——

  Five new pyranocoumarins, named cis-5-methoxydecursidinol (1), trans-5-methoxydecursidinol (2), cis-hassanin (4), trans-hassanin (5), and hassanidin (7), were isolated from the roots of some Citrus plants and their structures were elucidated by spectroscopic methods and chemical derivation from known coumarins.

  从一些柑橘类植物的根中分离出了五种新的吡喃香豆素，分别命名为顺式-5-甲氧基癸基香豆素醇（1）、反式-5-甲氧基癸基香豆素醇（2）、顺式-哈萨宁（4）、反式-哈萨宁（5）和哈萨宁（7），并通过光谱方法和已知香豆素的化学衍生方法阐明了它们的结构。
• Natural Product-like Combinatorial Libraries Based on Privileged Structures. 3. The “Libraries from Libraries” Principle for Diversity Enhancement of Benzopyran Libraries
  作者：K. C. Nicolaou、J. A. Pfefferkorn、S. Barluenga、H. J. Mitchell、A. J. Roecker、G.-Q. Cao

  DOI：10.1021/ja0020355

  日期：2000.10.1

  As described in the preceding two papers, our interest in the construction of natural and natural product-like libraries for chemical biology studies led to the development of a new solid-phase cycloloading strategy for the construction of substituted benzopyrans. Herein, we report a parallel solution-phase method that facilitates the enhancement of both the size and diversity of these non-oligomeric benzopyran libraries using the "libraries from libraries" principle. We examine the rationale behind the use of this tandem strategy to construct discrete small molecule libraries, and describe the development of a polymer-assisted solution-phase (PASP) methodology necessary to effect the required transformations. Once developed, this chemistry is applied to two demonstration libraries.