1,2-diisopropyl-4,4,5,5-tetramethylbiguanide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,2-diisopropyl-4,4,5,5-tetramethylbiguanide
• 英文别名: 2-[N,N'-di(propan-2-yl)carbamimidoyl]-1,1,3,3-tetramethylguanidine
• 化学式: C₁₂H₂₇N₅
• 分子量: 241.38
• InChiKey: UCRXZJYCOMRCER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  43.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,2-diisopropyl-4,4,5,5-tetramethylbiguanide 在 sodium hydride 作用下， 以 四氢呋喃 、 丙酮 、 mineral oil 为溶剂， 反应 2.17h， 生成 1,2-diisopropyl-1-methyl-4,4,5,5-tetramethylbiguanidium 2-(3-benzoylphenyl)propionate
  参考文献：
  名称：

  염기 발생제, 이 염기 발생제를 함유하는 염기 반응성 조성물 및 염기 발생 방법

  摘要：

  本发明旨在提供一种广泛用于有机溶剂中的高溶解度，可直接溶解环氧化合物等碱性反应性化合物，并具有高热稳定性和低核碱性性能的强碱生成剂，含有该碱生成剂和碱性反应性化合物的碱性反应性组合物，以及生成碱的方法。 本发明涉及一种以通式（A）表示的化合物，包括该化合物的碱生成剂，含有该碱生成剂和碱性反应性化合物的碱性反应性组合物，以及生成碱的方法等。（在上述式中，R～R分别独立地表示氢原子，烷基，取代基或含取代基的芳基或含取代基的芳基烷基，R表示氢原子，烷基，烯基，烷烃基，取代基或含取代基的芳基或含取代基的芳基烷基， R表示氢原子，氨基，烷基，取代基或含取代基的芳基或含取代基的芳基烷基，Z表示特定结构的羧酸衍生物的阴离子。）

  公开号：

  KR20160025587A
• 作为产物：
  描述：

  N,N'-二异丙基碳二亚胺 、 四甲基胍 以 N,N-二甲基甲酰胺 为溶剂， 以94%的产率得到1,2-diisopropyl-4,4,5,5-tetramethylbiguanide
  参考文献：
  名称：

  多氮强碱：1-双胍的新合成及其在酯交换反应中的催化性能

  摘要：

  通过将胍类如TMG和TDB亲核加成到二异丙基，二环己基和聚合芳族二酰亚胺上，已经开发了一种新的方便的方法来合成可溶性和聚苯乙烯负载的双胍。这些双胍是酯交换反应的优异催化剂。

  DOI：

  10.1016/s0040-4039(98)00300-1

文献信息

• BORATE-BASED BASE GENERATOR, AND BASE-REACTIVE COMPOSITION COMPRISING SUCH BASE GENERATOR
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD.

  公开号：US20160340374A1

  公开（公告）日：2016-11-24

  An object of the present invention is to provide a compound which is capable of attaining a composition having high storage stability without reacting with a base-reactive compound, even in the case of storage for a long period of time in a mixed state with the base-reactive compound, such as an epoxy-based compound, as well as capable of generating a strong base (guanidines, biguanides, phosphazenes or phosphoniums) by irradiation of light (active energy rays) or heating; a base generator comprising the compound; and a base-reactive composition comprising the base generator and the base-reactive compound. The present invention relates to the compound represented by the general formula (A); the base generator comprising the compound; and the base-reactive composition comprising the base generator and the base-reactive compound. (wherein R 1 represents an alkyl group; an arylalkynyl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; an alkenyl group; a 2-furylethynyl group; a 2-thiophenylethynyl group; or a 2,6-dithianyl group; R 2 to R 4 each independently represent an alkyl group; an arylalkynyl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; the aryl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; a furanyl group; a thienyl group; or an N-alkyl-substituted pyrrolyl group; Z + represents an ammonium cation having a guanidinium group, a biguanidium group or a phosphazenium group, or a phosphonium cation.)

  本发明的目的是提供一种化合物，能够在与碱反应性化合物混合状态长时间存储的情况下，仍能获得具有高储存稳定性的组合物，而不与碱反应性化合物发生反应，同时还能通过光照（活性能量射线）或加热产生强碱（胍胺、双胍胺、磷氮烷或磷銨）；包括该化合物的碱发生器；以及包括该碱发生器和碱反应性化合物的碱反应性组合物。本发明涉及由通式（A）表示的化合物；包括该化合物的碱发生器；以及包括该碱发生器和碱反应性化合物的碱反应性组合物。（其中R1代表烷基；可能被卤素原子、烷基、烷氧基或烷硫基取代的芳基炔基；烯基；2-呋喃基炔基；2-噻吩基炔基；或2,6-二硫基基；R2到R4各自独立地代表烷基；可能被卤素原子、烷基、烷氧基或烷硫基取代的芳基炔基；可能被卤素原子、烷基、烷氧基或烷硫基取代的芳基；呋喃基；噻吩基；或N-烷基取代的吡咯基；Z+代表具有胍胺基团、双胍胺基团或磷氮烷基团的铵阳离子，或磷銨阳离子。）
• ACID-RESISTANT BASE AND/OR RADICAL GENERATOR, AND CURABLE RESIN COMPOSITION CONTAINING SAID BASE AND/OR RADICAL GENERATOR
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD.

  公开号：US20190002403A1

  公开（公告）日：2019-01-03

  The present invention relates to a compound represented by the general formula (A), a base- and/or radical-generating agent comprising the compound, and so on. In the formula, four pieces of R 1 each independently represents a hydrogen atom or a fluorine atom; four pieces of R 2 each independently represent a fluorine atom or a trifluoromethyl group; R 3 , R 6 , R 7 and R 10 each independently represent a hydrogen atom or an alkyl group having 1 to 12 carbon atoms; R 4 and R 5 each independently represent a hydrogen atom or an alkyl group having 1 to 12 carbon atoms, or R 4 and R 5 are bonded to each other to represent an alkylene group having 2 to 4 carbon atoms; and R 8 and R 9 each independently represent a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, or an aryl group having 6 to 14 carbon atoms and optionally having a substituent selected from the group consisting of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, an alkylthio group having 1 to 6 carbon atoms, a dialkylamino group having 2 to 12 carbon atoms, a halogen atom, and a nitro group, or R 8 and R 9 are bonded to each other to represent an alkylene group having 2 to 4 carbon atoms; provided that two or three of the eight groups R 3 to R 10 are each a hydrogen atom, and, in a case where two of the eight groups are each a hydrogen atom, then three to six of the remaining groups are each an alkyl group having 1 to 12 carbon atoms, and, in a case where three of the eight groups are each a hydrogen atom, then four or five of the remaining groups are each an alkyl group having 1 to 12 carbon atoms.

  本发明涉及一种由通式（A）表示的化合物，包括该化合物的生成碱基和/或基团产生剂等。在该式中，四个R1分别独立表示氢原子或氟原子；四个R2分别独立表示氟原子或三氟甲基基团；R3、R6、R7和R10分别独立表示氢原子或具有1至12个碳原子的烷基基团；R4和R5分别独立表示氢原子或具有1至12个碳原子的烷基基团，或者R4和R5相互连接表示具有2至4个碳原子的亚烷基基团；R8和R9分别独立表示氢原子、具有1至12个碳原子的烷基基团或具有6至14个碳原子且可选地具有选自包括具有1至6个碳原子的烷基基团、具有1至6个碳原子的烷氧基团、具有1至6个碳原子的烷硫基团、具有2至12个碳原子的二烷基氨基团、卤素原子和硝基基团的取代基的芳基团，或者R8和R9相互连接表示具有2至4个碳原子的亚烷基基团；前提是八个基团R3至R10中的两个或三个分别是氢原子，并且在其中两个基团分别是氢原子的情况下，其余基团中的三到六个分别是具有1至12个碳原子的烷基基团，而在其中三个基团分别是氢原子的情况下，其余基团中的四个或五个分别是具有1至12个碳原子的烷基基团。
• Polynitrogen strong bases: 1-new syntheses of biguanides and their catalytic properties in transesterification reactions
  作者：Georges Gelbard、Florence Vielfaure-Joly

  DOI：10.1016/s0040-4039(98)00300-1

  日期：1998.4

  A new and convenient method has been developed for the synthesis of soluble and polystyrene-supported biguanides by the nucleophilic addition of guanidines such as TMG and TDB to diisopropyl-, dicyclohexyl- and polymericarbodi-imide. These biguanides are excellent catalysts for the transesterification.

  通过将胍类如TMG和TDB亲核加成到二异丙基，二环己基和聚合芳族二酰亚胺上，已经开发了一种新的方便的方法来合成可溶性和聚苯乙烯负载的双胍。这些双胍是酯交换反应的优异催化剂。
• PHOTOCURING METHOD, COMPOUND AND COMPOSITION USED THEREIN
  申请人：FUJIFILM Wako Pure Chemical Corporation

  公开号：US20190055210A1

  公开（公告）日：2019-02-21

  An object of the present invention is to provide a photocuring method, which makes it possible to rapidly and efficiently obtain a crosslinked product (resin), a compound used in the photocuring method, and a photocuring resin composition containing the compound. The present invention relates to a photocuring method, which comprises a step 1 and a step 2 performed after the step 1, a compound used in the photocuring method, and a photocuring resin composition containing the compound. Step 1: this is a step in which in the presence of (A) compound having a carbonyl group generating a radical by photoirradiation and a carboxyl group decarboxylated by photoirradiation, (B) silane coupling agent having a mercapto group or a (meth)acryl group is reacted with (C) water under acidic conditions to obtain (D) silane compound having a mercapto group or a (meth)acryl group and at least one silanol group. Step 2: this is a step in which in the presence of the compound (A) and (E) compound having a carbonyl group generating a radical by photoirradiation and a group generating a base by being decarboxylated by photoirradiation, the compound (A) and the compound (E) are irradiated with light to create alkaline conditions in a reaction system by decarboxylating the carboxyl group of the compound (A) and generating a base from the compound (E), and radicals are generated from the compound (A) and the compound (E) to generate a crosslinked product containing a constitutional unit derived from the silane compound (D) from the silane compound (D) and, if necessary, from (F) compound having two or more polymerizable unsaturated groups.

  本发明的一个目标是提供一种光固化方法，该方法使得能够快速高效地获得交联产物（树脂），以及用于光固化方法的化合物和含有该化合物的光固化树脂组合物。本发明涉及一种光固化方法，该方法包括在步骤1和步骤2之后执行的步骤1和步骤2，以及用于光固化方法的化合物和含有该化合物的光固化树脂组合物。步骤1：这是一个步骤，在该步骤中，在（A）具有通过光照生成自由基的羰基和通过光照脱羧生成羧基的化合物的存在下，（B）具有巯基或（甲基）丙烯基的硅烷偶联剂在酸性条件下与（C）水反应，以获得具有巯基或（甲基）丙烯基和至少一个硅醇基团的（D）硅烷化合物。步骤2：这是一个步骤，在该步骤中，在化合物（A）和（E）具有通过光照生成自由基的羰基和通过光照脱羧生成碱基的化合物的存在下，通过照射光线使化合物（A）和化合物（E）在反应系统中产生碱性条件，通过脱羧化合物（A）的羧基并从化合物（E）中生成碱基，并从化合物（A）和化合物（E）中生成自由基，从而生成包含从硅烷化合物（D）派生的构造单元的交联产物，如果需要，还可以从具有两个或更多可聚合不饱和基团的化合物（F）中派生。
• BASE GENERATOR, BASE-REACTIVE COMPOSITION CONTAINING SAID BASE GENERATOR, AND BASE GENERATION METHOD
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD.

  公开号：US20160122292A1

  公开（公告）日：2016-05-05

  It is a subject of the present invention to provide a base generator which has high solubility to general-purpose organic solvents, can dissolve directly into a base-reactive compound, such as an epoxy-based compound, further is provided with both performance of high heat resistance and low nucleophilicity, and generates a strong base, a base-reactive composition comprising the base generator and a base-reactive compound, as well as a method for generating a base, etc. The present invention relates to a compound represented by the general formula (A), a base generator comprising the compound, a base-reactive composition which comprises the base generator and a base-reactive compound, as well as a method for generating a base, etc. (wherein R 1 to R 5 each independently represent a hydrogen atom; an alkyl group; an aryl group which may have a substituent; or an arylalkyl group which may have a substituent, R 6 represents a hydrogen atom; an alkyl group which may have a substituent; an alkenyl group; an alkynyl group; an aryl group which may have a substituent; or an arylalkyl group which may have a substituent, R 7 represents a hydrogen atom; an alkyl group which may have an amino group; an aryl group which may have a substituent; or an arylalkyl group which may have a substituent, and Z − represents an anion derived from a carboxylic acid having a specific structure.)

  本发明的一个目的是提供一种基发生剂，其对通用有机溶剂具有高溶解度，可以直接溶解为一种碱反应性化合物，例如基于环氧树脂的化合物，进一步具有高耐热性和低亲核性的性能，并生成强碱，包括基发生剂和碱反应性化合物的碱反应性组合物，以及生成碱的方法等。本发明涉及一种由通式（A）表示的化合物，包括该化合物的基发生剂，包括基发生剂和碱反应性化合物的碱反应性组合物，以及生成碱的方法等。（其中R1至R5各自独立地表示氢原子；烷基基团；可能具有取代基的芳基团；或可能具有取代基的芳基烷基基团，R6表示氢原子；可能具有取代基的烷基基团；烯基基团；炔基基团；可能具有取代基的芳基团；或可能具有取代基的芳基烷基基团，R7表示氢原子；可能具有氨基的烷基基团；可能具有取代基的芳基团；或可能具有取代基的芳基烷基基团，Z-表示从具有特定结构的羧酸衍生的阴离子。）