2-(biphen-3-yloxy)-4-imidazol-1-ylmethyl-benzonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(biphen-3-yloxy)-4-imidazol-1-ylmethyl-benzonitrile
• 英文别名: 2-(Biphenyl-2-yloxy)-4-imidazol-1-ylmethyl-benzonitrile；4-(imidazol-1-ylmethyl)-2-(2-phenylphenoxy)benzonitrile
• 化学式: C₂₃H₁₇N₃O
• 分子量: 351.407
• InChiKey: RYKIAQZQXCZXEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  50.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氰基-3-氟苄溴 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 21.0h， 生成 2-(biphen-3-yloxy)-4-imidazol-1-ylmethyl-benzonitrile
  参考文献：
  名称：

  Diaryl ether inhibitors of farnesyl-protein transferase

  摘要：

  Imidazolemethyl diaryl ether are potent inhibitors of farnesyl-protein transferase. The SNAr displacement reaction used to prepare these diaryl ethers was amenable to rapid parallel synthesis of FPTase inhibitors. The use of a broad range of commercially available phenols quickly identified compounds which proved active in cells. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00162-7

文献信息

• Diaryl ether inhibitors of farnesyl-protein transferase
  作者：Suzanne C. MacTough、S.Jane deSolms、Anthony W. Shaw、Marc T. Abrams、Terrence M. Ciccarone、Joseph P. Davide、Kelly A. Hamilton、John H. Hutchinson、Kenneth S. Koblan、Nancy E. Kohl、Robert B. Lobell、Ronald G. Robinson、Samuel L. Graham

  DOI：10.1016/s0960-894x(01)00162-7

  日期：2001.5

  Imidazolemethyl diaryl ether are potent inhibitors of farnesyl-protein transferase. The SNAr displacement reaction used to prepare these diaryl ethers was amenable to rapid parallel synthesis of FPTase inhibitors. The use of a broad range of commercially available phenols quickly identified compounds which proved active in cells. (C) 2001 Elsevier Science Ltd. All rights reserved.