L-arginine nicotinate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-arginine nicotinate
• 英文别名: Arginine Nicotinate；(2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;pyridine-3-carboxylic acid
• 化学式: C₆H₅NO₂*C₆H₁₄N₄O₂
• 分子量: 297.314
• InChiKey: VMDCTAGTCGYQDX-WCCKRBBISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.82
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  182
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  烟酸 、 L-精氨酸 以 水 为溶剂， 反应 0.17h， 以100%的产率得到L-arginine nicotinate
  参考文献：
  名称：

  [EN] SALTS OF NICOTINIC ACID AND NICOTINAMIDE AS ANTI-AGING AGENTS
  [FR] SELS D'ACIDE NICOTINIQUE ET DE NICOTINAMIDE EN TANT QU'AGENTS ANTI-ÂGE

  摘要：

  本发明涉及烟酸和烟酰胺的氨基酸盐及其组合物，其化学式为I，用于治疗与NAD+缺乏相关的疾病和紊乱：（I）其中J、M1、R1和k如本文所述。

  公开号：

  WO2020028684A1

文献信息

• Method for reducing blood cholesterol using arginine
  申请人：——

  公开号：US05157022A1

  公开（公告）日：1992-10-20

  A method for reducing the level of cholesterol in the bloodstream of a human being in provided. The method comprises the administration to a human or arginine derivative compound, or a related amino acid or derivative. Daily doses of these compounds have been found to significantly reduce blood cholesterol level.

  提供了一种降低人体血液中胆固醇水平的方法。该方法包括向人体内注射精氨酸衍生物化合物或相关的氨基酸或衍生物。已发现每日剂量这些化合物可显著降低血液胆固醇水平。
• Sustained release L-arginine formulations and methods of manufacture and use
  申请人：Ron S. Eyal

  公开号：US20050287210A1

  公开（公告）日：2005-12-29

  The present invention provides methods and formulations for the treatment and prevention of cerebrovascular and cardiovascular diseases and disorders. The present invention is based, at least in part, on the discovery that administering to a subject a formulation comprising an agonist of endothelial nitric oxide synthase (eNOS), such as an HMG-CoA reductase inhibitor, and a formulation comprising a precursor of NO, such as L-arginine, may be used to treat or prevent cerebrovascular and/or cardiovascular diseases or disorders.

  本发明提供了治疗和预防脑血管和心血管疾病及紊乱的方法和制剂。本发明至少部分基于以下发现：给受试者施用包含内皮一氧化氮合酶（eNOS）激动剂（如 HMG-CoA 还原酶抑制剂）的制剂和包含 NO 前体（如 L-精氨酸）的制剂，可用于治疗或预防脑血管和/或心血管疾病或紊乱。
• Methods of treating various conditions by administration of sustained released L-Arginine
  申请人：Ron S. Eyal

  公开号：US20050288372A1

  公开（公告）日：2005-12-29

  The present invention provides methods for using L-arginine formulations, such as sustained release formulations, for various indications, including lowering triglyceride levels, inducing thermogenesis, weight loss and treatment and prevention of obesity and obesity related conditions, such as diabetes. Moreover, the present invention provides methods for treating or preventing other indications, such as asthma.

  本发明提供了将 L-精氨酸制剂（如缓释制剂）用于各种适应症的方法，包括降低甘油三酯水平、诱导产热、减肥以及治疗和预防肥胖和肥胖相关疾病（如糖尿病）。此外，本发明还提供了治疗或预防哮喘等其他适应症的方法。
• Methods of treating various conditions by administration of sustained release L-arginine
  申请人：Ron S. Eyal

  公开号：US20050288373A1

  公开（公告）日：2005-12-29

  The present invention provides methods for using L-arginine formulations, such as sustained release formulations, for various indications, including lowering triglyceride levels, inducing thermogenesis, weight loss and treatment and prevention of obesity and obesity related conditions, such as diabetes. Moreover, the present invention provides methods for treating or preventing other indications, such as asthma.

  本发明提供了将 L-精氨酸制剂（如缓释制剂）用于各种适应症的方法，包括降低甘油三酯水平、诱导产热、减肥以及治疗和预防肥胖和肥胖相关疾病（如糖尿病）。此外，本发明还提供了治疗或预防哮喘等其他适应症的方法。
• METHOD FOR REDUCING BLOOD CHOLESTEROL USING ARGININE
  申请人：BARBUL, Adrian

  公开号：EP0502007A1

  公开（公告）日：1992-09-09