Horseradish peroxidase catalyzed oxidative cross-coupling reactions: the synthesis of ‘unnatural’ dihydrobenzofuran lignans
摘要:
The possibility to afford by a biomimetic reaction 'unnatural' products, which could offer a better bioactivity profile than natural analogues, is outlined and the first applications to the synthesis of lignans and related compounds have been reported. Here we describe the synthesis of new heterodimers, having a phenylcoumaran skeleton, by horseradish peroxidase catalyzed cross-coupling reactions of methyl esters of substituted hydroxycinnamic acids. (C) 2011 Elsevier Ltd. All rights reserved.
Synthesis and Cytotoxicity of Novel Benzofuran Neolignan Derivatives
作者:Hua-Fang Fan、Ying-Mei Ren、Xiu-Ling Wu、Qiu-An Wang
DOI:10.3184/030823410x12709997864719
日期:2010.4
A series of 10 related benzofuranneolignan derivatives were obtained by utilising a biomimetic reaction sequence involving oxidative dimerisation of methyl ferulate, followed by derivatisation reactions. The structures of the new compounds were confirmed by 1H NMR, elemental analysis, MS and IR. All compounds were evaluated for their cytotoxic potential against five human cancer cell lines (HL-60
Derivatives of 8-epiblechnic Acid and their Effects on Down-Regulation of Endothelin (ETA) receptor mRNA
申请人:Chan Hardy
公开号:US20100048618A1
公开(公告)日:2010-02-25
The present application discloses derivatives of 8-epiblechnic acid and use thereof in treating a disease related to endothelin receptor A or endothelin-1 (ET-1) over-expression, such as hypertension, cancer, atherosclerosis, and myocardial infarction.