bromoethyltriphenylphosphine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bromoethyltriphenylphosphine
• 英文别名: 2-bromoethyl(triphenyl)-λ5-phosphane
• 化学式: C₂₀H₂₀BrP
• 分子量: 371.257
• InChiKey: KZHLEWAWYQVZKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.11
• 重原子数：
  22.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  bromoethyltriphenylphosphine 、 4-甲氧基苯甲醛 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 以70%的产率得到
  参考文献：
  名称：

  钴催化烯烃的Z到E异构化：（E）-β取代的苯乙烯的一种方法。

  摘要：

  开发了使用酰胺基-二膦配体的高效钴催化的β-取代的苯乙烯的Z到E异构化方法，提供了具有良好功能耐受性和高立体选择性的（E）异构体。使用（Z）-和（E）-烯烃的混合物作为起始原料，该反应可以在催化剂负载为0.1mol％的情况下按比例放大至克级。初步的机理研究表明，在实验和DFT计算的支持下，钴（I）氢化物和苄基钴可能参与了反应。

  DOI：

  10.1021/acs.orglett.0c00072

文献信息

• NOVEL 20,21-DINOR-EBURNAMENINE
  申请人：——

  公开号：US20020045637A1

  公开（公告）日：2002-04-18

  A compound selected from the group consisting of all possible isomers or racemates of a compound of the formula 1 wherein X 1 , X 2 and X 3 are individually selected from the group consisting of hydrogen, halogen, unsubstituted or substituted alkyl of 1 to 18 carbon atoms, unsubstituted or substituted alkenyl and alkynyl of 2 to 18 carbon atoms, unsubstituted or substituted alkoxy of 1 to 7 carbon atoms, —OH, —CF 3 , —NO 21 —NH 21 mono and dialkylamino of 1 to 4 alkyl carbon atoms and unsubstituted or substituted phenyl, 2 R is selected from the group consisting of unsubstituted or substituted alkyl of 1 to 7 carbon atoms, unsubstituted or substituted alkenyl and alkynyl of 2 to 7 carbon atoms, unsubstituted or substituted phenyl and carboxy optionally salified or esterified, R 1 is 3 or ═C═CH—R 10 , one of R 8 and R 9 is selected from the group consisting of hydrogen, unsubstituted or substituted alkyl of 1 to 6 carbon atoms, unsubstituted or substituted alkenyl and alkynyl of 2 to 6 carbon atoms, unsubstituted or substituted phenyl, esterified carboxy, —CN and acyl of 2 to 6 carbon atoms and the other and R 10 are selected from the group consisting of hydrogen, unsubstituted or substituted alkyl of 1 to 6 carbon atoms, unsubstituted or substituted alkenyl and alkynyl of 2 to 6 carbon atoms and unsubstituted or substituted phenyl and its non-toxic, pharmaceutically acceptable salts with acids or bases having anti-anoxic, anti-ischemic and neuronal protective anti-depressant activities.

  从化合物选择的组中选择一种化合物，该组由公式1的所有可能异构体或外消旋体组成，其中X1、X2和X3分别选择自氢、卤素、1到18个碳原子的未取代或取代烷基、2到18个碳原子的未取代或取代烯基和炔基、1到7个碳原子的未取代或取代烷氧基、—OH、—CF3、—NO21—NH21、1到4个烷基碳原子的单烷基或双烷基氨基和未取代或取代苯基，2R选择自1到7个碳原子的未取代或取代烷基、2到7个碳原子的未取代或取代烯基和炔基、未取代或取代苯基和羧基可选地被盐化或酯化，R1是3或═C═CH—R10，R8和R9中的一个选择自氢、1到6个碳原子的未取代或取代烷基、2到6个碳原子的未取代或取代烯基和炔基、未取代或取代苯基、酯化羧基、—CN和2到6个碳原子的酰基，另一个和R10选择自氢、1到6个碳原子的未取代或取代烷基、2到6个碳原子的未取代或取代烯基和炔基、未取代或取代苯基及其无毒、药学上可接受的酸或碱盐，具有抗缺氧、抗缺血和神经保护抗抑郁活性。
• Tracheal smooth muscle relaxants
  申请人：——

  公开号：US20030065021A1

  公开（公告）日：2003-04-03

  The present invention offers a tracheal smooth muscle relaxant containing the compound represented by the following formula (1) or pharmacologically acceptable salt thereof as an effective ingredient. 1 [In the formula, X and Y each is any group selected from a group consisting of CH 2 , CHW 1 (where W 1 is halogen atom, hydroxyl group or lower alkoxy group) and C═O when the bond of X and Y is a single bond while, when it is a double bond, X and Y each is any group selected from a group consisting of CH and COW 2 (where W 2 is lower alkyl group or lower alkylcarbonyl group); Z is O, S, S═O or SO 2 ; and R 1 ˜R 8 each is selected from a group consisting of hydrogen atom, VR 9 (where V is O, S, S═O or SO 2 ; and R 9 is hydrogen atom, lower alkyl group, hydroxy lower alkyl group, lower acyl group, trihalomethyl group or carboxyl lower alkyl group), carboxyl lower alkyl group, hydroxy lower alkyl group, hydroxy lower alkenyl group, hydroxy lower alkynyl group, halogen atom, lower alkyl group, lower alkyl ketone, trihalomethyl group, trimethylsilylethynyl, nitro group, amino group, N-carbonyl lower alkyl group, lower alkylphenyl group and phenyl group].

  本发明提供了一种气管平滑肌松弛剂，其含有以下公式（1）所表示的化合物或其药理学上可接受的盐作为有效成分。1＆lsqb;在公式中，当X和Y的键为单键时，X和Y各为从CH2，CHW1（其中W1为卤原子，羟基或较低的烷氧基）和C═O组成的群体中选择的任何一种群体；当它是双键时，X和Y各为从CH和COW2（其中W2为较低的烷基或较低的烷基羰基基团）组成的群体中选择的任何一种群体；Z为O、S、S═O或SO2；R1〜R8各为从氢原子、VR9（其中V为O、S、S═O或SO2；R9为氢原子、较低的烷基、羟基较低的烷基、较低的酰基、三卤甲基或羧基较低的烷基）组成的群体中选择的任何一种群体、羧基较低的烷基、羟基较低的烷基、羟基较低的烯基、羟基较低的炔基、卤原子、较低的烷基、较低的烷基酮、三卤甲基、三甲基硅基乙炔基、硝基、氨基、N-羰基较低的烷基、较低的烷基苯基和苯基。
• TRACHEAL SMOOTH MUSCLE RELAXANT
  申请人：NIPPON SUISAN KAISHA, LTD.

  公开号：EP0885610A1

  公开（公告）日：1998-12-23

  The present invention offers a tracheal smooth muscle relaxant containing the compound represented by the following formula (1) or pharmacologically acceptable salt thereof as an effective ingredient.    [In the formula, X and Y each is any group selected from a group consisting of CH2, CHW1 (where W1 is halogen atom, hydroxyl group or lower alkoxy group) and C=O when the bond of X and Y is a single bond while, when it is a double bond, X and Y each is any group selected from a group consisting of CH and COW2 (where W2 is lower alkyl group or lower alkylcarbonyl group); Z is O, S, S=O or SO2; and R1∼R8 each is selected from a group consisting of hydrogen atom, VR9 (where V is O, S, S=O or SO2; and R9 is hydrogen atom, lower alkyl group, hydroxy lower alkyl group, lower acyl group, trihalomethyl group or carboxyl lower alkyl group), carboxyl lower alkyl group, hydroxy lower alkyl group, hydroxy lower alkenyl group, hydroxy lower alkynyl group, halogen atom, lower alkyl group, lower alkyl ketone, trihalomethyl group, trimethylsilylethynyl, nitro group, amino group, N-carbonyl lower alkyl group, lower alkylphenyl group and phenyl group].

  本发明提供了一种气管平滑肌松弛剂，其有效成分含有下式(1)所代表的化合物或其药理上可接受的盐。 [式中，当 X 和 Y 的键为单键时，X 和 Y 各为选自 CH2、CHW1（其中 W1 为卤原子、羟基或低级烷氧基）和 C=O 组成的组中的任意基团；而当为双键时，X 和 Y 各为选自 CH 和 COW2（其中 W2 为低级烷基或低级烷基羰基）组成的组中的任意基团；Z是O、S、S=O或SO2；以及 R1∼R8各自选自由氢原子、VR9（其中V是O、S、S=O或SO2；R9为氢原子、低级烷基、羟基低级烷基、低级酰基、三卤甲基或羧基低级烷基）、羧基低级烷基、羟基低级烷基、羟基低级烯基、羟基低级炔基、卤素原子、低级烷基、低级烷基酮、三卤甲基、三甲基硅烷基、硝基、氨基、N-羰基低级烷基、低级烷基苯基和苯基]。
• 2,3,5-TRISUBSTITUTED PYRIDINES AS INHIBITORS OF CYCLOOXYGENASE-2
  申请人：MERCK FROSST CANADA & CO.

  公开号：EP1012142B1

  公开（公告）日：2004-08-11
• Nouveaux dérivés du nonatriène-1,3,5, leur préparation et leur emploi
  申请人：RHONE-POULENC SANTE

  公开号：EP0309340B1

  公开（公告）日：1991-05-29