2-carboxypropyltriphenyl-phosphonium bromide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-carboxypropyltriphenyl-phosphonium bromide
• 英文别名: 2-carboxypropyltriphenylphosphonium bromide；2-carboxypropyl(triphenyl)phosphanium;bromide
• 化学式: Br*C₂₂H₂₂O₂P
• 分子量: 429.293
• InChiKey: PJHFZUZGCCZNSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.71
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-carboxypropyltriphenyl-phosphonium bromide 、 对甲氧基苯乙酮 在 sodium hydride 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 生成 (3E)-4-(4-methoxyphenyl)-pent-3-enoic acid
  参考文献：
  名称：

  Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives

  摘要：

  本发明涉及一类由公式I代表的化合物 1 或其药用可接受的盐，包含公式I化合物的药物组合物，以及选择性地抑制或拮抗α v β 3 和/或α v β 5 整合素的方法。

  公开号：

  US20040092538A1
• 作为产物：
  描述：

  甲基2,3-二溴-2-甲基丙酸酯 、 三苯基膦 在 水 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以53.3%的产率得到2-carboxypropyltriphenyl-phosphonium bromide
  参考文献：
  名称：

  Reactions of triphenylphosphine with 2,3-dihalo-2-methylpropionic acids and their methyl esters

  摘要：

  Triphenylphosphine reacts with 2,3-dichloro-2-methylpropionic acid and its ester along the dehydrochlorination pathway with the participation of the less labile hydrogen atom from the methyl group. The subsequent reaction of the unsaturated product with triphenylphosphine yields 2-carboxypropane- and 2-methoxycarbonylpropane-1,3-diylbis(triphenylphosphonium) dichlorides, respectively. The unusual course of dehydrochlorination may be due to easier electron density transfer from the C-H bond of the methyl group as compared to the chloromethyl group in the carbocationoid intermediate. With the bromine analogs, the reaction pathways are different. The ester reacts similarly to dibromopropionic acid and its derivatives, following the debromination scheme, whereas the free acid gives the product of double nucleophilic substitution.

  DOI：

  10.1134/s1070363207060138

文献信息

• Novel substituted indolines with an inhibitory effect on various kinases and complexes of CDKs
  申请人：Boehringer Ingelheim Pharma KG

  公开号：US20040058978A1

  公开（公告）日：2004-03-25

  The present invention relates to new substituted indolinones of general formula 1 wherein X and R 1 to R 5 are defined as in claim 1, the isomers and the salts thereof which have valuable properties. The above compounds of general formula I wherein R 1 denotes a hydrogen atom, a C 1-3 -alkyl group or a prodrug group have valuable pharmacological properties, particularly an inhibiting effect on various kinases, on viral cyclin and on receptor tyrosine kinases, and the other compounds of the above general formula I wherein R 1 does not represent a hydrogen atom, a C 1-3 -alkyl group or a prodrug group are valuable intermediate products for the preparation of the abovementioned compounds.

  本发明涉及一种新的通式1的取代吲哚酮，其中X和R1至R5的定义如权利要求书1中所述，其异构体和盐具有有价值的性质。通式I中的上述化合物，其中R1表示氢原子，C1-3-烷基或前药基，具有有价值的药理学性质，特别是对多种激酶、病毒细胞周期蛋白和受体酪氨酸激酶具有抑制作用，上述通式I中R1不表示氢原子、C1-3-烷基或前药基的其他化合物是制备上述化合物的有价值中间体。
• NEUE SUBSTITUIERTE INDOLINONE MIT EINER INHIBIERENDEN WIRKUNG AUF VERSCHIEDENE KINASEN UND CYCLIN/CDK-KOMPLEXE
  申请人：Boehringer Ingelheim Pharma GmbH & Co.KG

  公开号：EP1115704B1

  公开（公告）日：2003-06-18
• US6855710B2
  申请人：——

  公开号：US6855710B2

  公开（公告）日：2005-02-15
• US6921767B2
  申请人：——

  公开号：US6921767B2

  公开（公告）日：2005-07-26
• [EN] NOVEL PROCESSES FOR THE SYNTHESIS OF CYCLOPROPYL COMPOUNDS<br/>[FR] NOUVEAUX PROCESSUS DE SYNTHESE DE COMPOSES DE CYCLOPROPYLE
  申请人：PHARMACIA CORP

  公开号：WO2005051904A2

  公开（公告）日：2005-06-09

  This invention relates to processes for the preparation of cyclopropyl compounds of Formula: (I) wherein: x is an integer selected from the group consisting of 0, 1 and 2; R1 and R2 are independently selected from the group consisting of H, C1-C6 alkyl, and halo; and R3, R4, R5, R6 and R7 are independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, and halo.