3,3',3"-(benzene-1,3,5-triyltris(oxy))tris(propan-1-amine)

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3,3',3"-(benzene-1,3,5-triyltris(oxy))tris(propan-1-amine)
• 英文别名: 3-[3,5-Bis(3-aminopropoxy)phenoxy]propan-1-amine；3-[3,5-bis(3-aminopropoxy)phenoxy]propan-1-amine
• 化学式: C₁₅H₂₇N₃O₃
• 分子量: 297.398
• InChiKey: MBAAMSXFPDVGBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  21
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(2-amino-2-oxoethoxy)-N,N-dioctylacetamide 、 3,3',3"-(benzene-1,3,5-triyltris(oxy))tris(propan-1-amine) 在 三乙胺 作用下， 以 甲苯 为溶剂， 生成 N-[3-[3,5-bis[3-[[2-[2-(dioctylamino)-2-oxoethoxy]acetyl]amino]propoxy]phenoxy]propyl]-2-[2-(dioctylamino)-2-oxoethoxy]acetamide
  参考文献：
  名称：

  以苯为中心的三脚架二甘醇酰胺螯合三价act系元素：室温离子液体中的金属离子萃取和发光光谱研究

  摘要：

  评估了三个以苯为中心的三脚架二甘醇酰胺（Bz-T-DGA）配体，其中二甘醇酰胺（DGA）部分通过乙烯间隔基（LI），酰胺基（LII）或醚键（LIII）连接至中心苯环其在室温离子液体（RTIL）中对三价act系元素和镧系元素离子的萃取行为。1-丁基-3-甲基咪唑鎓双（三氟甲烷）磺酰亚胺（[C4mim] [Tf2N]）。将这些配体在[C4mim] [Tf2N]介质中的萃取行为与在分子溶剂正十二烷中获得的萃取行为进行了比较，显示出LIII> LII> LI与LI> LII> LIII具有相反的选择性。与其中溶剂化萃取机理占优势的正十二烷介质相反，在RTIL介质中发现阳离子交换机理是有效的。发现萃取的Am3 +配合物的化学计量为1：2（金属/配体），萃取的配合物中不存在硝酸根离子。[C4mim] [Tf2N]相中Eu3 + /配体提取的配合物的发光光谱证实没有水分子，并且金属离子的所有主要配位位点

  DOI：

  10.1039/c7dt01954h
• 作为产物：
  描述：

  tert-butyl N-[3-[3,5-bis[3-[(2-methylpropan-2-yl)oxycarbonylamino]propoxy]phenoxy]propyl]carbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 3,3',3"-(benzene-1,3,5-triyltris(oxy))tris(propan-1-amine)
  参考文献：
  名称：

  Protected fluorescent reagent compounds

  摘要：

  提供了受保护的荧光试剂化合物及其合成方法。这些化合物在各种基于荧光的分析方法中很有用，包括在大量高密度下进行高度多重光学反应的分析，例如单分子实时核酸测序反应。这些化合物包含荧光染料元素，使得这些化合物能够在理想波长下以高灵敏度被检测到，结合元素使这些化合物能够被目标生物分子特异性识别，并且保护性屏障元素减少了荧光染料元素与结合的目标生物分子之间的不良接触，从而减少了荧光染料元素对结合的目标生物分子的光损伤。

  公开号：

  US09957291B2

文献信息

• PROTECTED FLUORESCENT REAGENT COMPOUNDS
  申请人：Pacific Biosciences of California, Inc.

  公开号：US20150050659A1

  公开（公告）日：2015-02-19

  Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The compounds contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements.

  提供了受保护的荧光试剂化合物及其合成方法。这些化合物在各种基于荧光的分析方法中很有用，包括在高密度下对大量高度多重光学反应进行分析，例如单分子实时核酸测序反应。这些化合物包含荧光染料元素，使得这些化合物能够在理想波长下以高灵敏度被检测到，结合元素，使得这些化合物能够被特异性地识别目标生物分子，并且保护盾元素，减少荧光染料元素与结合的目标生物分子之间的不良接触，从而减少荧光染料元素对结合的目标生物分子造成的光损伤。
• MULTIMERIC PROTECTED FLUORESCENT REAGENTS
  申请人：Pacific Biosciences of California, Inc.

  公开号：US20160237279A1

  公开（公告）日：2016-08-18

  Multimeric protected fluorescent reagents and their methods of synthesis are provided. The reagents are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The reagents contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements. The reagents also contain coupling elements connect monomeric compounds into multimeric forms, thereby increasing brightness.

  提供了多聚保护荧光试剂及其合成方法。这些试剂在各种基于荧光的分析方法中很有用，包括在高密度下分析高度多重光学反应，比如单分子实时核酸测序反应。这些试剂包含荧光染料元素，允许化合物在理想波长下以高灵敏度被检测，结合元素，允许化合物被目标生物分子特异性识别，以及保护屏障元素，减少荧光染料元素与结合的目标生物分子之间的不良接触，从而减少荧光染料元素对结合的目标生物分子的光损伤。这些试剂还包含耦合元素，将单体化合物连接成多聚形式，从而增加亮度。
• Multimeric protected fluorescent reagents
  申请人：Pacific Biosciences of California, Inc.

  公开号：US10150872B2

  公开（公告）日：2018-12-11

  Multimeric protected fluorescent reagents and their methods of synthesis are provided. The reagents are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The reagents contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements. The reagents also contain coupling elements connect monomeric compounds into multimeric forms, thereby increasing brightness.

  本文提供了多聚体保护荧光试剂及其合成方法。这些试剂适用于各种基于荧光的分析方法，包括分析大量高密度的高度复用光学反应，如单分子实时核酸测序反应。这些试剂含有荧光染料元件，可在理想波长下以高灵敏度检测化合物；结合元件，可使化合物被目标生物大分子特异性识别；保护罩元件，可减少荧光染料元件与结合的目标生物大分子之间的不良接触，从而减少荧光染料元件对结合的目标生物大分子的光损伤。试剂中还含有将单体化合物连接成多聚体形式的偶联元件，从而提高亮度。
• US9957291B2
  申请人：——

  公开号：US9957291B2

  公开（公告）日：2018-05-01
• [EN] PROTECTED FLUORESCENT REAGENT COMPOUNDS<br/>[FR] COMPOSÉS RÉACTIFS FLUORESCENTS PROTÉGÉS
  申请人：PACIFIC BIOSCIENCES CALIFORNIA

  公开号：WO2015021079A1

  公开（公告）日：2015-02-12

  Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The compounds contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements.