dimethyl 1-(trimethylsiloxy)-2-phenylethanephosphonate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: dimethyl 1-(trimethylsiloxy)-2-phenylethanephosphonate
• 英文别名: (1-Dimethoxyphosphoryl-2-phenylethoxy)-trimethylsilane
• 化学式: C₁₃H₂₃O₄PSi
• 分子量: 302.382
• InChiKey: JDQKQCQVHBPJNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.89
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  氧化苯乙烯 、 三甲基氯硅烷 、 三甲氧基磷 在 lithium perchlorate 作用下， 以 乙醚 为溶剂， 以92%的产率得到dimethyl 1-(trimethylsiloxy)-2-phenylethanephosphonate
  参考文献：
  名称：

  A novel procedure for conversion of epoxides to α-hydroxyphosphonates with a trialkylphosphite mediated by LiClO4

  摘要：

  A new method has been developed for the direct conversion of epoxides to alpha-hydroxyphosphonates by the reaction of a trialkylphosphite with the epoxide in 5 M lithium perchlorate in diethyl ether (LPDE). The reaction is highly regioselective and efficient with excellent yields under mild and neutral conditions. (C) 2003 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2003.09.002

文献信息

• A novel procedure for conversion of epoxides to α-hydroxyphosphonates with a trialkylphosphite mediated by LiClO4
  作者：Najmoddin Azizi、Mohammad R Saidi

  DOI：10.1016/j.tetlet.2003.09.002

  日期：2003.10

  A new method has been developed for the direct conversion of epoxides to alpha-hydroxyphosphonates by the reaction of a trialkylphosphite with the epoxide in 5 M lithium perchlorate in diethyl ether (LPDE). The reaction is highly regioselective and efficient with excellent yields under mild and neutral conditions. (C) 2003 Published by Elsevier Ltd.