二十二碳六烯酰甘氨酸 | 132850-40-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 二十二碳六烯酰甘氨酸
• 英文名称: N-Docosa-4,7,10,13,16,19-hexaenoylglycine
• 英文别名: 2-(docosa-4,7,10,13,16,19-hexaenoylamino)acetic acid
• CAS: 132850-40-9
• 化学式: C₂₄H₃₅NO₃
• 分子量: 385.5
• InChiKey: BEYWKSIFICEQGH-UHFFFAOYSA-N

物化性质

• 沸点：
  582.1±50.0 °C(Predicted)
• 密度：
  0.996±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（高达25mg/ml）或乙醇（高达25mg/ml）。

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  28
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• FATTY ACID ANTIVIRAL CONJUGATES AND THEIR USES
  申请人：Catabasis Pharmaceuticals, Inc.

  公开号：US20160129122A1

  公开（公告）日：2016-05-12

  The invention relates to fatty acid antiviral conjugates; compositions comprising an effective amount of a fatty acid antiviral conjugate; and methods for treating or preventing a viral infection comprising the administration of an effective amount of a fatty acid antiviral conjugate.

  这项发明涉及脂肪酸抗病毒共轭物；包含有效量脂肪酸抗病毒共轭物的组合物；以及治疗或预防病毒感染的方法，包括给予有效量脂肪酸抗病毒共轭物。
• PREPARATION OF AMINO ACID-FATTY ACID AMIDES
  申请人：Chaudhuri Shan

  公开号：US20080200704A1

  公开（公告）日：2008-08-21

  The present invention describes compounds produced from an amino acid molecule and a fatty acid molecule. The compounds being in the form of amino-fatty acid compounds being bound by an amide linkage, or mixtures thereof made by reacting amino acids or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental amino acids with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.

  本发明描述了由氨基酸分子和脂肪酸分子产生的化合物。这些化合物采用酰胺键结合的氨基脂肪酸化合物的形式存在，或者是由氨基酸或其衍生物与先前与硫酰卤反应的适当脂肪酸反应而成的混合物。这些分子的使用可提供具有增强生物利用度和特定脂肪酸所赋予的额外益处的补充氨基酸。
• METHODS OF LOWERING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9)
  申请人：Catabasis Pharmacauticals, Iinc.

  公开号：US20150344430A1

  公开（公告）日：2015-12-03

  The invention relates to new methods of modulating cholesterol by inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9) with fatty acid derivatives; and new methods for treating or preventing a metabolic disease comprising the administration of an effective amount of a fatty acid derivative. The present invention is also directed to fatty acid bioative derivatives and their use in the treatment of metabolic diseases.

  本发明涉及使用脂肪酸衍生物抑制前蛋白酶转化酶亚精氨酸/酶切割酶9 (PCSK9)来调节胆固醇的新方法；以及通过给予有效量的脂肪酸衍生物来治疗或预防代谢性疾病的新方法。本发明还涉及脂肪酸生物活性衍生物及其在治疗代谢性疾病中的应用。
• DERIVATIVES OF DOCOSAHEXAENOYLETHANOLAMIDE AND USES THEREOF
  申请人：The United States of America, as Represented by The Secretary, Department of Health and Human Services

  公开号：EP2847178B1

  公开（公告）日：2017-01-04
• US9422308B2
  申请人：——

  公开号：US9422308B2

  公开（公告）日：2016-08-23