N'-(1-phenylethylidene)propionohydrazide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-(1-phenylethylidene)propionohydrazide
• 英文别名: N-(1-phenylethylideneamino)propanamide
• 化学式: C₁₁H₁₄N₂O
• 分子量: 190.245
• InChiKey: DZYFXFBPLAGLPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  丙酸 、 苯乙酮 在 一水合肼 作用下， 反应 6.5h， 以93%的产率得到N'-(1-phenylethylidene)propionohydrazide
  参考文献：
  名称：

  Synthesis ofN-Acyl Triazolyl-Pyrazolines via Acylation Initiated by the Hydrazone Moiety with Carboxylic Acids

  摘要：

  An efficient synthesis of N-acyl/N-substituted acyl pyrazolines and their triazole hybrids have been accomplished via acylation of pyrazolines and pyrazoline-triazole hybrids with carboxylic acids and/or substituted carboxylic acids in the absence of activating agents/catalysts. In the present study, a mechanism envisaging the in situ generation of a new transient acylating intermediate has been proposed to explain the acylation.

  DOI：

  10.1080/00397911.2015.1104357

文献信息

• Synthesis of<i>N</i>-Acyl Triazolyl-Pyrazolines via Acylation Initiated by the Hydrazone Moiety with Carboxylic Acids
  作者：Archana Sivasubramaniyan、Dinesh Murugan、Ranganathan Raja、Sathishkumar Murugan、Shanmugavelan Poovan、Ponnuswamy Alagusundaram

  DOI：10.1080/00397911.2015.1104357

  日期：2015.12.2

  An efficient synthesis of N-acyl/N-substituted acyl pyrazolines and their triazole hybrids have been accomplished via acylation of pyrazolines and pyrazoline-triazole hybrids with carboxylic acids and/or substituted carboxylic acids in the absence of activating agents/catalysts. In the present study, a mechanism envisaging the in situ generation of a new transient acylating intermediate has been proposed to explain the acylation.