rhein arginine

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: rhein arginine
• 英文别名: rhein L-arginine；(2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid
• 化学式: C₆H₁₄N₄O₂*C₁₅H₈O₆
• 分子量: 458.428
• InChiKey: CVTDISBHCCQJPA-VWMHFEHESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.02
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  240
• 氢给体数：
  7
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  大黄酚 在 chromium(VI) oxide 作用下， 以 乙醇 、 水 、 乙酸酐 、 溶剂黄146 为溶剂， 反应 8.0h， 生成 rhein arginine
  参考文献：
  名称：

  RHEIN CONJUGATES, PREPARATION METHOD THEREOF AND THEIR USES IN PRODUCING MEDICINES FOR TREATING DIABETIC NEPHROSIS, INTESTINAL ADHESION AND OSTEOARTHRITIS

  摘要：

  公开号：

  EP1913940B8

文献信息

• Rhein Conjugates, Preparation Method Thereof and Their Uses in Producing Medicines for Treating Diabetic Nephrosis, Intestinal Adhesion and Osteoarthritis
  申请人：Cong Xiaodong

  公开号：US20080207758A1

  公开（公告）日：2008-08-28

  The conjugates of present invention are formed by the combination of rhein or their analogues with the organic bases or amino acids in molecular force between them. The methods for preparing the conjugates and their uses for manufacturing medicines in the treatment of diabetic nephrosis, recovery of gastrointestinal function and prevention of intestinal adhesion, as well as treatment of osteoarthritis, rheumatic arthritis and rheumatoid arthritis are also described. Rhein or their analogues as the left part of general formula (I) is selected from (1) the compounds of rhein or their analogues, in which one or two substituents of R2˜R3 and R6˜R7 are COOH at least two substituents of R1˜8 are —H; or (2) the rhein-containing extract derived from plants. In general formula (I), M represents nitrogen-containing organic bases or basic amino acids.

  本发明的共轭物由大黄素或其类似物与有机碱或氨基酸在它们之间的分子力相互作用而形成。描述了制备这些共轭物的方法以及它们在制造治疗糖尿病性肾病、恢复胃肠功能和预防肠粘连，以及治疗骨关节炎、风湿性关节炎和类风湿性关节炎的药物中的用途。大黄素或其类似物作为通式（I）的左部分，从（1）大黄素或其类似物的化合物中选择，其中R2˜R3和R6˜R7的一个或两个取代基至少有两个R1˜8的取代基为—H；或（2）来自植物的含有大黄素的提取物。在通式（I）中，M代表含氮有机碱或碱性氨基酸。
• RHEIN CONJUGATES, PREPARATION METHOD THEREOF AND THEIR USES IN PRODUCING MEDICINES FOR TREATING DIABETIC NEPHROSIS, INTESTINAL ADHESION AND OSTEOARTHRITIS
  申请人：Cong, Xiaodong

  公开号：EP1913940B8

  公开（公告）日：2019-04-24