n-Heptan-sulfonsaeure-(3)

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: n-Heptan-sulfonsaeure-(3)
• 英文别名: heptane-3-sulfonic acid；Heptan-3-sulfonsaeure
• 化学式: C₇H₁₆O₃S
• 分子量: 180.268
• InChiKey: FBXSJNBOMIHLEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲酸 、 双氧水 作用下， 生成 n-Heptan-sulfonsaeure-(3)
  参考文献：
  名称：

  THE REPLACEMENT OF SECONDARY HYDROXYL GROUPS BY SULFONIC ACID SUBSTITUENTS¹

  摘要：

  DOI：

  10.1021/jo01127a003

文献信息

• Mercury-photosensitized sulfination, hydrosulfination, and carbonylation of hydrocarbons: alkane and alkene conversion to sulfonic acids, ketones, and aldehydes
  作者：Richard R. Ferguson、Robert H. Crabtree

  DOI：10.1021/jo00019a006

  日期：1991.9

  Mercury-photosensitized sulfination of alkanes, RH, with SO2 forms sulfinic acids (RSOOH) and sulfinate esters (RSOOR) in high conversion and yield; oxidation of the mixture produces RSO2OH in high yield. Mercury-photosensitized hydrosulfination of alkenes with H2 and SO2 gives RSO2OH after oxidative workup. Mercury-photosensitized carbonylation of alkanes with CO gives RCHO and R2CO.
• Wol'fson; Mel'nikow, Zhurnal Obshchei Khimii, 1950, vol. 20, p. 2089,2090;engl.Ausg.S.2163
  作者：Wol'fson、Mel'nikow

  DOI：——

  日期：——
• LINKERS AND THEIR APPLICATION TOWARDS ADC
  申请人：MEDSHINE DISCOVERY INC.

  公开号：US20170202974A1

  公开（公告）日：2017-07-20

  The present invention relates to linkers, containing amide surrogates with a regular or a novel lysosomal enzymatic cleavable dipeptidic unit, to connect cytotoxic drugs to antibodies. The present invention also relates to ADCs (antibody-drug conjugates) derived from these amide surrogate linkers for the treatment of cancers.
• THE REPLACEMENT OF SECONDARY HYDROXYL GROUPS BY SULFONIC ACID SUBSTITUENTS¹
  作者：LESTER YODER

  DOI：10.1021/jo01127a003

  日期：1955.10