N-chloro-p-methoxybenzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-chloro-p-methoxybenzenesulfonamide
• 英文别名: N-chloro-4-methoxybenzenesulfonamide
• 化学式: C₇H₈ClNO₃S
• 分子量: 221.664
• InChiKey: HXLXAVXSHIUKCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  63.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-氯-N,N-二异丙胺 、 对甲氧基苯磺酰胺 以 水 为溶剂， 生成 N-chloro-p-methoxybenzenesulfonamide 、 二异丙胺
  参考文献：
  名称：

  氯胺-T与仲胺之间氯交换动力学和机理中结构活性的考量。

  摘要：

  为了研究氯胺-T对仲胺进行N-氯化的机理，测定了N-氯苯磺酰胺的一些芳族取代类似物与各种仲胺反应的动力学。还评估了胺碱性和N-氯苯磺酰胺N-Cl键反应性的重要性。结果表明，涉及两种反应物的非电离物质的一种机理（即分子机理），而不是离子机理，正在运行，并且该反应最有可能通过结合了六价环的六元环过渡态进行。水分子。

  DOI：

  10.1002/jps.2600810713

文献信息

• Sulfonamide analogues of galiellalactone
  申请人：GLACTONE PHARMA DEVELOPMENT AB

  公开号：US10781197B2

  公开（公告）日：2020-09-22

  Disclosed are sulfonamide analogues of galiellactone of formula (I) as STAT3-inhibitors for use in the treatment of a STAT3 signaling related disorder, e.g. solid cancers, hematological cancers, benign tumors, hyperproliferative diseases, inflammations, autoimmune diseases, graft or transplant rejections, delayed physiological function of grafts or transplants, neurodegenerative diseases and viral infections. The sulfonamide comprises a cyclic substituent.

  本发明公开了作为 STAT3 抑制剂的式(I)的镓内酯磺酰胺类似物，用于治疗 STAT3 信号转导相关疾病，如实体癌、血液肿瘤、良性肿瘤、过度增殖性疾病、炎症、自身免疫性疾病、移植物或移植排斥、移植物或移植的生理功能延迟、神经退行性疾病和病毒感染。磺酰胺包括一个环状取代基。
• Use of halo active aromatic sulfonamides for odor control
  申请人：Schneider, David J.

  公开号：EP1940784B1

  公开（公告）日：2013-09-18
• SULFONAMIDE ANALOGUES OF GALIELLALACTONE
  申请人：Glactone Pharma Development AB

  公开号：EP3548475B1

  公开（公告）日：2021-03-03
• PROCESS FOR STAIN REMOVAL
  申请人：Schneider David J.

  公开号：US20090227485A1

  公开（公告）日：2009-09-10

  Disclosed are processes whereby stains on a variety of substrates may be removed by treating a stained area of a substrate with a solution of a sulfonamide compound. The sulfonamide-containing solutions are particularly useful as stain removal agents for stains which originate with body fluids such as blood, urine, vomit, feces etc. The stain removal solutions may be buffered to a predetermined pH. The stain removal solutions may further incorporate small percentages of low molecular weight alcohols and wetting agents.
• NEW HALO ACTIVE AROMATIC SULFONAMIDE ORGANIC COMPOUNDS AND ODOR CONTROL USES THEREFOR
  申请人：Schneider David J.

  公开号：US20100041761A1

  公开（公告）日：2010-02-18

  Aromatic N-halosulfonamide organic compounds have been known for over one hundred years. The ability of these compounds to release active halogen ions has been utilized in a range of biocidal and fungicidal applications. The most widely used halogen sulfonamide organic compound for these applications is Chloramine-T. This invention deals with the new use of discovered compositions of matter, halo active aromatic sulfonamide organic compounds and use of solutions of these compounds as, odor control agents. The odor control solutions may be buffered to a predetermined pH. The odor control compositions may further incorporate small percentages of low molecular weight alcohols and wetting agents.