decarboxymethyl elenoic acid dialdehydic form

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: decarboxymethyl elenoic acid dialdehydic form
• 英文别名: decarboxymethyl elenolic acid dialdehydic form；EDA；4-Formyl-3-(formylmethyl)-4-hexenoic acid；(E)-4-formyl-3-(2-oxoethyl)hex-4-enoic acid
• 化学式: C₉H₁₂O₄
• 分子量: 184.192
• InChiKey: DBMWDRVDXUPGBP-UQCOIBPSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-formyl-3-(2-oxoethyl)-4-hexenoic acid 2-(3,4-dihydroxyphenyl)ethyl ester 在 盐酸 、 水 作用下， 反应 0.08h， 生成 羟基酪醇 、 decarboxymethyl elenoic acid dialdehydic form
  参考文献：
  名称：

  Main Antimicrobial Compounds in Table Olives

  摘要：

  The inhibitors involved in the lactic acid fermentation of table olives were investigated in aseptic olive brines of the Manzanilla and Gordal varieties. Phenolic and oleosidic compounds in these brines were identified by high-performance liquid chromatography with ultraviolet and electrospray ionization mass spectrometry detection, and several substances were also characterized by nuclear magnetic resonance. Among these compounds, the dialdehydic form of clecarboxymethyl elenolic acid linked to hydroxytyrosol showed the strongest antilactic acid bacteria activity, and its presence in brines could explain the growth inhibition of these microorganisms during olive fermentation. However, it was found that the dialclehydic form of decarboxymethyl elenolic acid, identified for the first time in table olives, and an isomer of oleoside 11-methyl ester were also effective against Lactobacillus pentosus and can, therefore, contribute to the antimicrobial activity of olive brines. It must also be stressed that the three new inhibitors discovered in table olive brines exerted a more potent antibacterial activity than the well-studied oleuropein and hydroxytyrosol.

  DOI：

  10.1021/jf0719757

文献信息

• ANALOGUES OF OLEUROPEIN AND OLEACEIN AND USES THEREOF
  申请人：Attica Sciences Ltd.

  公开号：US20220110962A1

  公开（公告）日：2022-04-14

  Analogues of oleuropein and oleacein and pharmaceutically acceptable salts thereof and processes for the preparation of these compounds are disclosed. The invention further relates to use of oleuropein and oleacein analogues for the treatment of inflammatory disorders, cardiometabolic disorders, and cancer.

  本发明公开了欧洲橄榄苦苷和欧洲橄榄苦酸及其药学上可接受的盐的类似物，以及制备这些化合物的方法。本发明还涉及使用欧洲橄榄苦苷和欧洲橄榄苦酸类似物治疗炎症性疾病、心脏代谢性疾病和癌症的方法。
• Mittel und Verfahren zur Gerbung von Häuten und Fellen
  申请人：N-Zyme BioTec GmbH

  公开号：EP2062985A1

  公开（公告）日：2009-05-27

  Verfahren zur Gerbung von Häuten und Fellen, dadurch gekennzeichnet, dass Häute und Felle mit Gerbstoffen enthaltend deglycosylierte Iridoide und/oder deglycosylierte Secoiridoide behandelt werden.

  一种鞣制皮革的工艺，其特征在于用含有脱糖鸢尾酮和/或脱糖仲鸢尾酮的鞣剂处理皮革。
• MITTEL UND VERFAHREN ZUR GERBUNG VON HÄUTEN UND FELLEN
  申请人：N-Zyme BioTec GmbH

  公开号：EP2215274B1

  公开（公告）日：2011-04-13
• OLIVENBLATTEXTRAKT
  申请人：N-Zyme BioTec GmbH

  公开号：EP3337339A1

  公开（公告）日：2018-06-27
• AGENT AND METHOD FOR TANNING SKINS AND PELTS
  申请人：Zotzel Jens

  公开号：US20100275380A1

  公开（公告）日：2010-11-04

  Process for the tanning of hides and skins, characterized in that hides and skins are treated with tanning agents containing deglycosylated iridoids and/or deglycosylated secoiridoids, excluding tanning agents containing genipin.