3-(selenophen-2-yl)oxazolidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-(selenophen-2-yl)oxazolidin-2-one
• 英文别名: 3-Selenophen-2-yl-1,3-oxazolidin-2-one
• 化学式: C₇H₇NO₂Se
• 分子量: 216.098
• InChiKey: RZZALPRVSIGSSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-碘硒吩 、 2-唑烷酮 在 potassium phosphate 、 copper(l) iodide 、 乙二胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以90%的产率得到3-(selenophen-2-yl)oxazolidin-2-one
  参考文献：
  名称：

  Copper-Promoted Carbon−Nitrogen Bond Formation with 2-Iodo-selenophene and Amides

  摘要：

  [GRAPHICS]We present here carbon-nitrogen bond formation via a coupling reaction of 2-iodo-selenophene catalyzed by Cu(I) in the presence of a base and an inexpensive ligand, and establish the first route to obtaining 2-nitrogen-selenophene derivatives in good yields. We can anticipate that this reaction works well with oxazolidinones, lactams, and aliphatic and aromatic amides, as nitrogen sources, in the absence of any supplementary additives. In addition, the reaction proceeded cleanly under mild reaction conditions and was sensitive to the ratio of amide/2-iodo-selenophene, as well as the nature of the ligand, base, and solvent.

  DOI：

  10.1021/jo052234c

文献信息

• Copper-Promoted Carbon−Nitrogen Bond Formation with 2-Iodo-selenophene and Amides
  作者：Olga Soares do Rêgo Barros、Cristina W. Nogueira、Eluza C. Stangherlin、Paulo Henrique Menezes、Gilson Zeni

  DOI：10.1021/jo052234c

  日期：2006.2.1

  [GRAPHICS]We present here carbon-nitrogen bond formation via a coupling reaction of 2-iodo-selenophene catalyzed by Cu(I) in the presence of a base and an inexpensive ligand, and establish the first route to obtaining 2-nitrogen-selenophene derivatives in good yields. We can anticipate that this reaction works well with oxazolidinones, lactams, and aliphatic and aromatic amides, as nitrogen sources, in the absence of any supplementary additives. In addition, the reaction proceeded cleanly under mild reaction conditions and was sensitive to the ratio of amide/2-iodo-selenophene, as well as the nature of the ligand, base, and solvent.