1-allyl-3-iodobenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-allyl-3-iodobenzene
• 英文别名: 1-Iodo-3-prop-2-enylbenzene；1-iodo-3-prop-2-enylbenzene
• 化学式: C₉H₉I
• 分子量: 244.075
• InChiKey: HRJQZPNHVYMTEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-allyl-3-iodobenzene 在 Zeise's dimer 、 三氯硅烷 作用下， 以 吡啶 、 二氯甲烷 为溶剂， 反应 24.75h， 生成 1-iodo-3-(3-(triisopropoxysilyl)propyl)benzene
  参考文献：
  名称：

  A new synthetic approach for functional triisopropoxyorganosilanes using molecular building blocks

  摘要：

  We report an efficient synthetic approach for well-designed organic-bridged alkoxysilanes, which allow the formation of highly functional organosilica hybrids under mild sol gel conditions. A series of molecular building blocks containing a triisopropoxysilyl group were synthesized and used in cross-coupling reactions. The triisopropoxysilyl group showed a good tolerance for various organic transformations. 1,4-Diketo-3,6-dithienylpyrrolo[3,4-c]pyrrole-bridged triisopropoxysilane was successfully prepared, allowing rapid formation of organosilica hybrid without loss of functionality under mildly acidic conditions. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.04.130
• 作为产物：
  描述：

  1-烯丙基-3-溴苯 在 正丁基锂 、 异丙基氯化镁 、 碘 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 24.5h， 以87%的产率得到1-allyl-3-iodobenzene
  参考文献：
  名称：

  A new synthetic approach for functional triisopropoxyorganosilanes using molecular building blocks

  摘要：

  We report an efficient synthetic approach for well-designed organic-bridged alkoxysilanes, which allow the formation of highly functional organosilica hybrids under mild sol gel conditions. A series of molecular building blocks containing a triisopropoxysilyl group were synthesized and used in cross-coupling reactions. The triisopropoxysilyl group showed a good tolerance for various organic transformations. 1,4-Diketo-3,6-dithienylpyrrolo[3,4-c]pyrrole-bridged triisopropoxysilane was successfully prepared, allowing rapid formation of organosilica hybrid without loss of functionality under mildly acidic conditions. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.04.130

文献信息

• Generation of arylzinc reagents through an iodine–zinc exchange reaction promoted by a non-metallic organic superbase
  作者：Hiroshi Naka、Keisuke Ito、Masahiro Ueno、Koji Kobayashi、Yoshinori Kondo

  DOI：10.1039/c0nj00202j

  日期：——

  Functionalized aryl and heteroaryl zinc reagents were prepared from aryl iodides and diethylzinc through t-Bu-P4 base-promoted iodine–zinc exchange reactions. The scope and limitations of this protocol, and several applications for the synthesis of oligoaryls and fused aromatics, are presented.

  通过t-Bu-P4碱促进的碘-锌交换反应，从碘苯和二乙基锌制备了功能化的芳基和杂芳基锌试剂。介绍了这一方法的应用范围和局限性，并展示了用于合成多芳基和融合芳香化合物的几种应用。
• Preparation of Functionalized Diorganomagnesium Reagents in Toluene via Bromine or Iodine/Magnesium-Exchange Reactions
  作者：Alexandre Desaintjean、Fanny Danton、Paul Knochel

  DOI：10.1055/a-1551-4093

  日期：2021.12

  Br/Mg-exchange reaction using reagents of the general formula R2Mg (R = sBu, Mes). Highly sensitive functional groups, such as triazene or nitro, are tolerated in these exchange reactions, enabling the synthesis of various functionalized (hetero)arene and alkene derivatives after quenching with several electrophiles including allyl bromides, acyl chlorides, aldehydes, ketones, and aryl iodides.

  在 –78 °C 和 25 °C 之间，通过 I/Mg 或 Br/Mg 交换反应，在甲苯中，在 10 到 120 分钟内，使用以下试剂制备各种多官能化二（杂）芳基和二烯基镁试剂通式 R2Mg (R = sBu, Mes)。在这些交换反应中可以耐受三氮烯或硝基等高度敏感的官能团，在用烯丙基溴、酰氯、醛、酮和芳基碘等多种亲电试剂淬灭后，可以合成各种功能化的（杂）芳烃和烯烃衍生物.
• MIDA boronate allylation – synthesis of ibuprofen
  作者：David Phillips、Glen Brodie、Sarah Memarzadeh、Gi Lum Tang、David J. France

  DOI：10.1039/d0ra03338c

  日期：——

  MIDA boronates are among the most useful reagents for the Suzuki–Miyaura reaction. This chemistry typically generates new bonds between two aromatic rings, thereby restricting access to important areas of chemical space. Here we demonstrate the coupling of MIDA boronates to allylic electrophiles, including a new synthesis of the well-known COX inhibitor ibuprofen.

  MIDA 硼酸盐是铃木-宫浦反应最有用的试剂之一。这种化学通常会在两个芳环之间产生新的键，从而限制进入化学空间的重要区域。在这里，我们展示了 MIDA 硼酸盐与烯丙基亲电子试剂的偶联，包括众所周知的 COX 抑制剂布洛芬的新合成。
• Synthesis of Highly Substituted Cyclobutanones by a One‐Pot Keteniminium‐Enamine Process
  作者：Dylan Dagoneau、Amandine Kolleth、Pierre Quinodoz、Beyza Horoz、Saron Catak、Alexandre Lumbroso、Sarah Sulzer‐Mossé、Alain De Mesmaeker

  DOI：10.1002/hlca.202100022

  日期：2021.5

  synthesis of highly substituted cyclobutanones. This process relies on first a [2+2] cycloaddition involving a keteniminium salt intermediate with an alkene followed by isomerization of the resulting cyclobutaniminium salt into its cyclic enamine form and then reaction of the latter with an electrophile. The adduct can be either hydrolyzed or reduced to give the corresponding cyclobutanone or cyclobutanamine

  在本文中，我们描述了有效的一锅序列，用于高度取代的环丁酮的区域和立体选择性合成。该方法首先依赖于[2 + 2]环加成反应，该加成反应包括将烯酮铵盐中间体与烯键合，然后将所得的环丁铵盐异构化成其环状烯胺形式，然后使后者与亲电子试剂反应。可以将加合物水解或还原，分别得到相应的环丁酮或环丁胺，并具有出色的非对映异构控制能力。容许多种亲电试剂，从而允许将各种取代基和官能团结合到环丁基环上。此外，通过DFT研究研究了各种环烯胺的共面性。
• Resin composition, prepreg, metal foil-clad laminate, resin composite sheet, and printed wiring board
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：US11008420B2

  公开（公告）日：2021-05-18

  Provided is a resin composition comprising a polymaleimide compound (A) represented by the following general formula (1), a modified polyphenylene ether (B) having a terminal modified with a substituent containing a carbon-carbon unsaturated double bond, and a filler (C): wherein a plurality of R each independently represent a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, or a phenyl group; and n is an average value and represents 1

  本发明提供了一种树脂组合物，该树脂组合物由以下通式（1）表示的聚马来酰亚胺化合物（A）、末端被含有碳碳不饱和双键的取代基修饰的改性聚苯醚（B）和填料（C）组成： 其中多个 R 各自独立地代表氢原子、具有 1 至 5 个碳原子的烷基或苯基；n 为平均值，代表 1＜n≤5。