N-butyl-4-aminobenzophenone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-butyl-4-aminobenzophenone
• 英文别名: [4-(Butylamino)phenyl]-phenylmethanone
• 化学式: C₁₇H₁₉NO
• 分子量: 253.344
• InChiKey: DMZOHLNSFFJNFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-溴苯甲酰苯 、 正丁胺 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 作用下， 以96%的产率得到N-butyl-4-aminobenzophenone
  参考文献：
  名称：

  芳基卤化物的钯催化胺化：机理和合理的催化剂设计

  摘要：

  三邻甲苯基膦和双（二苯基膦基）二茂铁的钯配合物在碱存在下催化芳基卤化物与锡酰胺或胺之间的反应，通过卤化物取代形成芳基胺。该帐户描述了我们与胺化反应相关的机械和合成研究。这些研究包括催化系统的动力学行为以及对包含催化作用的主要化学计量反应的直接观察 - 包括罕见的 CN 键形成还原消除 - 以及这些单独反应的机制。本文还描述了无锡酰胺源和第二代胺化催化剂的开发，这些催化剂源于我们对胺化化学的机械理解。

  DOI：

  10.1055/s-1997-789

文献信息

• A Second-Generation Catalyst for Aryl Halide Amination:  Mixed Secondary Amines from Aryl Halides and Primary Amines Catalyzed by (DPPF)PdCl₂
  作者：Michael S. Driver、John F. Hartwig

  DOI：10.1021/ja960937t

  日期：1996.1.1
• Palladium-Catalyzed Amination of Aryl Triflates and Importance of Triflate Addition Rate
  作者：Janis Louie、Michael S. Driver、Blake C. Hamann、John F. Hartwig

  DOI：10.1021/jo961930x

  日期：1997.3.1

  We report that a combination of DPPF (1,1-bis(diphenylphosphino)ferrocene) and Pd(dba)(2) leads to the amination of aryl triflates, a reaction that allows for the conversion of phenols to arylamines. A combination of BINAP and Pd(dba)(2) also catalyzes the amination of aryl triflates, but P(o-tolyl)(3) complexes were not effective catalysts. In some cases, slow addition of the aryl triflate was necessary to prevent cleavage of the triflate and generation of phenol. We found that added halide, necessary in some cross-coupling chemistry of aryl sulfonates, was an unnecessary additive and even inhibited the amination chemistry.
• PHOTOPOLYMERIZED RESIN LAMINATE AND METHOD FOR MANUFACTURING BOARD HAVING BLACK MATRIX PATTERN
  申请人：Kurita Hideaki

  公开号：US20100092892A1

  公开（公告）日：2010-04-15

  An object is to manufacture a substrate having a black matrix pattern with excellent ink repellency on the surface by an easy method. A fluorine-containing compound coated film in which 1 to 60 mm 3 of an organic material layer containing 30 to 100% of a fluorine-containing compound is provided on a supporting film per 1 m 2 of the supporting film and the organic material layer has a contact angle to xylene of 20 degrees or more is used.
• US4264710A
  申请人：——

  公开号：US4264710A

  公开（公告）日：1981-04-28
• US5817877A
  申请人：——

  公开号：US5817877A

  公开（公告）日：1998-10-06