The primary toxic effects of 3,3-dichloropropene are portal-of-entry effects resulting from the chemical reactivity of the compound and its physicochemical properties. Repeated irritation results in a hyperplastic response in the target tissues (L893).
来源:Toxin and Toxin Target Database (T3DB)
毒理性
致癌物分类
对人类无致癌性（未列入国际癌症研究机构IARC清单）。
No indication of carcinogenicity to humans (not listed by IARC).
Ingestion of 3,3-D can lead to developed gastrointestinal distress, adult respiratory distress syndrome, hematological and hepatorenal functional impairment, acute gastrointestinal distress with pulmonary congestion and edema, central nervous depression, perhaps even in the absence of impaired oxygen uptake. Moreover, this can lead to death. Coma may occur rapidly after inhalation. Severe skin irritation with marked inflammatory response of epidermis can underlying tissues can follow dermal exposure. By any route, possible late injuries to liver, kidneys and heart (T48).
Symptoms occuring after inhalation include gasping, refusal to breathe, coughing, substernal pain; lacrimation and headache are prominant. After inhalation exposures, malaise, headache, chest and abdominal discomfort and irritability can persist during weeks or years. Moreover, Irritation of eyes and upper respiratory mucosa appears promptly after exposure to concentrated vapors. Ingestion can cause cough, sore throat, headache, dizziness, nausea, vomiting, unconsciousness, and laboured breathing (T48, L893).
A Practical Synthesis of Polyhalomethyllithium-Carbonyl Adducts
作者：Hiroaki Taguchi、Hisashi Yamamoto、Hitosi Nozaki
DOI：10.1246/bcsj.50.1588
日期：1977.6
of a mixture of polyhalomethane and a carbonylcompound with a hindered lithium amide. The kinetically controlled, selective lithiation of the halide enables us to avoid a troublesome procedure involving preformed lithiumcarbenoid. The halide components examined are dichloromethane, dibromomethane, diiodomethane, chloroform, and bromoform, while the carbonyl ones are ubiquitous ketones and nonanal
implemented before in a totalsynthesis context. We used density functional theory calculations to guide our strategic choices concerning a [2.3]-Wittig rearrangement step and the final ring-size selective Yamaguchi macrolactonization. This led to two syntheses of the aglycone of tiacumicinB, with one of last generation delivering ultimately an adequately protected and glycosylation-ready aglycone.
with indiummetal, and their reactions with carbonyl compounds and electron-deficientalkenes were examined. The reactions of simple 1,1-diiodoalkanes with indiummetal gave no defined products but benzal iodide gave stilbene in a moderate yield. α-Halo organoindium reagents drived from α,α-dibromo carbonyl compounds gave oxiranes and cyclopropanes upon the reactions with aldehydes and alkenes, respectively
Treatment of (3,3-dialkyl-2,2-dichlorocyclopropyl)methanols with hydrobromic acid gives 2-cyclopentenones through postulated intermediates, 3-chlorocyclopentadienyl cations. Another method which sh...
Experiments with thioacetals and related substances. Part IV. Anionotropic rearrangements of gem-bisalkylthio-propenes and -butenes
作者：Eugene Rothstein、Derek J. Stanbank、Ronald Whiteley
DOI：10.1039/j39680000746
日期：——
As a consequence of discrepancies in the literature, further investigations have been made concerning the identities of certain bisalkylthioalkenes and the possible existence of equilibria between the two isomers: R1CH:CH·CH(SR2)2⇌ R1CH(SR2)·CH:CH·SR2(R2= Et or Bun)
