N-(p-nitrophenyl)sarcosine sodium salt

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(p-nitrophenyl)sarcosine sodium salt
• 英文别名: sodium N-methyl-N-(4-nitrophenyl)glycinate；sodium;2-(N-methyl-4-nitroanilino)acetate
• 化学式: C₉H₉N₂O₄*Na
• 分子量: 232.171
• InChiKey: MXVIBYVYFLDRGZ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.22
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  89.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(p-nitrophenyl)sarcosine sodium salt 在 sodium tetrahydroborate 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  Silver nanoparticles stabilized by a polyaminocyclodextrin as catalysts for the reduction of nitroaromatic compounds

  摘要：

  Silver nanoparticles stabilized by means of poly-(6-N,N-dimethyl-propylenediamino)-(6-deoxy)-beta-cyclodextrin were synthesized, characterized by different techniques (UV-vis spectroscopy, Dynamic Light Scattering, High Resolution Transmission Electron Microscopy, Fourier-transform IR Spectroscopy) and used as catalysts for the reduction of various nitrobenzene derivatives with sodium borohydride. The nanocomposites obtained appear to have an organized structure, with a metal core surrounded by a layer-structured coating shell. Kinetic data, rationalized in terms of a modified Langmuir-Hinshelwood model, evidenced a non-linear dependence of the reaction rate on the concentration of the catalyst. This was explained on the grounds of the catalytic activity of differently covered catalyst areas. Careful analysis of kinetic data, in particular the effect of the para substituent on the nitroarene structure and the trends of the induction period observed at the beginning of the reaction, provided with interesting insights on the reaction course, and brought us to critically reconsider several mechanistic ideas reported in previous literature. (C) 2015 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2015.07.031
• 作为产物：
  描述：

  N-(p-nitrophenyl)sarcosine 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成 N-(p-nitrophenyl)sarcosine sodium salt
  参考文献：
  名称：

  α-和β-环糊精与某些对硝基苯胺衍生物结合的热力学：重新考虑焓-熵补偿效应

  摘要：

  研究了天然α-和β-环糊精与几种对硝基苯胺衍生物结合的热力学，以进一步了解两种宿主不同相互作用模式的发生。获得了有关α-环糊精“扩展疏水球”的宝贵信息。此外，β-环糊精的行为非常有趣和出乎意料的方面也得到了启发，例如氢键相互作用所起的关键作用。在“焓-熵补偿效应”的角度检查了实验数据，并讨论了有关该主题的一些想法。

  DOI：

  10.1016/j.tet.2004.07.079

文献信息

• Binding abilities of polyaminocyclodextrins: polarimetric investigations and biological assays
  作者：Marco Russo、Daniele La Corte、Annalisa Pisciotta、Serena Riela、Rosa Alduina、Paolo Lo Meo

  DOI：10.3762/bjoc.13.271

  日期：——

  polyamine pendant bush at the primary rim was positively assessed. Insights on quantitative aspects of the interaction between our materials and polyanions were investigated by studying the binding with sodium alginate. Finally, the complexation abilities of the same materials towards polynucleotides were assessed by studying their interaction with the model plasmid pUC19. Our results positively highlight

  研究了七（6-脱氧-6-碘）-β-环糊精与适当的线性多胺直接反应制得的三种聚氨基环糊精材料的结合性能，以评估其在生物系统（如载体）中的潜在应用用于同时吸收药物和基因细胞，或用于保护大分子。尤其是，我们利用偏光法测试了它们与某些模型对硝基苯胺衍生物（被选​​作探针访客）的相互作用。获得的数据表明，宿主腔内部的结合主要受库仑相互作用和构象约束之间的相互作用影响。此外，积极评估了阳离子聚胺侧基在主边的同时相互作用。通过研究与藻酸钠的结合，研究了我们的材料与聚阴离子之间相互作用的定量方面的见解。最后，通过研究它们与模型质粒pUC19的相互作用来评估相同材料对多核苷酸的复合能力。我们的结果肯定地突出了我们的材料利用空腔和聚阳离子分支的能力，从而起到了双峰配体的作用。
• Thermodynamics of binding between α- and β-cyclodextrins and some p-nitro-aniline derivatives: reconsidering the enthalpy–entropy compensation effect
  作者：Paolo Lo Meo、Francesca D'Anna、Michelangelo Gruttadauria、Serena Riela、Renato Noto

  DOI：10.1016/j.tet.2004.07.079

  日期：2004.10

  The thermodynamics of binding between native α- and β-cyclodextrin towards several p-nitro-aniline derivatives was examined, in order to gain further insights about the occurrence of different interaction modes for the two hosts. Valuable information was achieved regarding the ‘expanded hydrophobic sphere’ of α-cyclodextrin. Furthermore, very interesting and unexpected aspects of the behavior of β-cyclodextrin

  研究了天然α-和β-环糊精与几种对硝基苯胺衍生物结合的热力学，以进一步了解两种宿主不同相互作用模式的发生。获得了有关α-环糊精“扩展疏水球”的宝贵信息。此外，β-环糊精的行为非常有趣和出乎意料的方面也得到了启发，例如氢键相互作用所起的关键作用。在“焓-熵补偿效应”的角度检查了实验数据，并讨论了有关该主题的一些想法。
• Silver nanoparticles stabilized by a polyaminocyclodextrin as catalysts for the reduction of nitroaromatic compounds
  作者：Marco Russo、Francesco Armetta、Serena Riela、Delia Chillura Martino、Paolo Lo Meo、Renato Noto

  DOI：10.1016/j.molcata.2015.07.031

  日期：2015.11

  Silver nanoparticles stabilized by means of poly-(6-N,N-dimethyl-propylenediamino)-(6-deoxy)-beta-cyclodextrin were synthesized, characterized by different techniques (UV-vis spectroscopy, Dynamic Light Scattering, High Resolution Transmission Electron Microscopy, Fourier-transform IR Spectroscopy) and used as catalysts for the reduction of various nitrobenzene derivatives with sodium borohydride. The nanocomposites obtained appear to have an organized structure, with a metal core surrounded by a layer-structured coating shell. Kinetic data, rationalized in terms of a modified Langmuir-Hinshelwood model, evidenced a non-linear dependence of the reaction rate on the concentration of the catalyst. This was explained on the grounds of the catalytic activity of differently covered catalyst areas. Careful analysis of kinetic data, in particular the effect of the para substituent on the nitroarene structure and the trends of the induction period observed at the beginning of the reaction, provided with interesting insights on the reaction course, and brought us to critically reconsider several mechanistic ideas reported in previous literature. (C) 2015 Elsevier B.V. All rights reserved.