4-(7-Chloro-4-quinazolinylamino)benzenesulphonic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-(7-Chloro-4-quinazolinylamino)benzenesulphonic acid
• 英文别名: 4-[(7-chloroquinazolin-4-yl)amino]benzenesulfonic acid
• 化学式: C₁₄H₁₀ClN₃O₃S
• 分子量: 335.771
• InChiKey: SNUUIHWDRLXFSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-(7-Chloro-4-quinazolinylamino)benzenesulphonic acid 生成 4-[(7-Chloroquinazolin-4-yl)amino]benzenesulfonyl chloride
  参考文献：
  名称：

  BOYLE, J. T. A.;TODD, R. S.

  摘要：

  DOI：
• 作为产物：
  描述：

  4,7-二氯喹唑啉 、 对氨基苯磺酸 以 乙醇 为溶剂， 生成 4-(7-Chloro-4-quinazolinylamino)benzenesulphonic acid
  参考文献：
  名称：

  4-(cinnolinylamino or quinazolinylamino)benzenesulphonamides and

  摘要：

  具有以下结构式的新奎奈唑和咪唑衍生物（其中A和B中的一个是CH，另一个是N；X1是卤素或CF3，X3是II、III、IV或V中的一个基团，其中Q是较低的烷基烯；R1是氢或较低的烷基；R2和R3是独立的较低烷基，或者R2和R3是一种双价基团，使得HNR2R3是具有5至7个环原子的二级环胺；R4是较低的烷基；n为0或1；在III和IV式中显示的环是哌啶或吡咯啉，可以选择地被较低的烷基取代；在V式中显示的环是哌嗪，可以选择地被较低的烷基取代），以及它们的药学上可接受的盐在药物学中特别作为降压药物是有用的。还描述了新的中间体，包括式I的相应磺酸（其中A、B和X1如上所定义，X3是OH）。

  公开号：

  US04640920A1

文献信息

• 4-substituted-N-(piperidinyl or pyrrolidinyl)alkyl benzenesulfonamides
  申请人：John Wyeth & Brother Limited

  公开号：US04734510A1

  公开（公告）日：1988-03-29

  Novel quinazoline and cinnoline derivatives having the formula ##STR1## (wherein one of A and B is CH and the other one of A and B is N; X.sub.1 is halogen or CF.sub.3 and X.sub.3 is one of the groups II, III, IV or V ##STR2## where Q is lower alkylene; R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.3 are independently lower alkyl or R.sub.2 and R.sub.3 are a divalent radical such that HNR.sub.2 R.sub.3 is a secondary cyclic amine with 5 to 7 ring atoms; R.sub.4 is lower alkyl; n is 0 or 1; the rings shown in formulae III and IV are piperidine or pyrrolidine optionally substituted by lower alkyl; and the ring shown in formula V is piperazine optionally substituted by lower alkyl) and their pharmaceutically acceptable salts are useful as pharmaceuticals particularly as anti-hypertensives. Novel intermediates are also described including the corresponding sulphonic acids of formula I (where A, B and X.sub.1 are defined above and X.sub.3 is OH).

  具有以下式子的新型喹嗪和咪唑啉衍生物##STR1##（其中A和B中的一个是CH，另一个是N；X.sub.1是卤素或CF.sub.3，X.sub.3是II，III，IV或V组之一##STR2##其中Q是低碳链；R.sub.1是氢或低碳基；R.sub.2和R.sub.3独立地是低碳基或R.sub.2和R.sub.3是二价基团，使得HNR.sub.2 R.sub.3是具有5到7个环原子的次级环状胺；R.sub.4是低碳基；n为0或1；在式III和IV中显示的环是哌啶或吡咯啉，可以选择地被低碳基取代；在式V中显示的环是哌嗪，可以选择地被低碳基取代），以及它们的药物可接受盐，可用作药物，特别是作为抗高血压药物。还描述了新的中间体，包括式I的相应磺酸（其中A，B和X.sub.1如上定义，X.sub.3为OH）。
• 4-quinazolinylamino and 4-cinnolinylamino benzenesulphonic acids and
  申请人：John Wyeth & Brother Limited

  公开号：US04808715A1

  公开（公告）日：1989-02-28

  Novel quinazoline and cinnoline derivatives having the formula ##STR1## (wherein one of A and B is CH and the other one of A and B is N; X.sub.1 is halogen or CF.sub.3 and X.sub.3 is one of the groups II, III, IV or V ##STR2## where Q is lower alkylene; R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.3 are independently lower alkyl or R.sub.2 and R.sub.3 are a divalent radical such that HNR.sub.2 R.sub.3 is a secondary cyclic amine with 5 to 7 ring atoms; R.sub.4 is lower alkyl; n is 0 or 1; the rings shown in formulae III and IV are piperidine or pyrrolidine optionally substituted by lower alkyl; and the ring shown in formula V is piperazine optionally substituted by lower alkyl) and their pharmaceutically acceptable salts are useful as pharmaceuticals particularly as anti-hypertensives. Novel intermediates are also described including the corresponding sulphonic acids of formula I ( (where A, B and X.sub.1 are defined above and X.sub.3 is OH).

  具有以下公式的新奎嗪和茚嗪衍生物的化合物适用于制药，特别是作为降压药物：##STR1##（其中A和B中的一个是CH，另一个是N；X.sub.1是卤素或CF.sub.3，X.sub.3是II，III，IV或V中的一个基团##STR2##其中Q是低烷基；R.sub.1是氢或低烷基；R.sub.2和R.sub.3是独立的低烷基，或者R.sub.2和R.sub.3是二价基团，使得HNR.sub.2 R.sub.3是具有5到7个环原子的二级环状胺；R.sub.4是低烷基；n为0或1；公式III和IV中显示的环是哌啶或吡咯啉，可选择地被低烷基取代；公式V中显示的环是哌嗪，可选择地被低烷基取代。其中药学上可接受的盐也适用于制药。还描述了新的中间体，包括公式I的相应磺酸（其中A，B和X.sub.1如上定义，X.sub.3为OH）。
• BOYLE, J. T. A.;TODD, R. S.
  作者：BOYLE, J. T. A.、TODD, R. S.

  DOI：——

  日期：——
• PEPTIDOMIMETIC MODULATORS OF CELL ADHESION
  申请人：Gour J. Barbara

  公开号：US20080081831A1

  公开（公告）日：2008-04-03

  Peptidomimetics of cyclic peptides, and compositions comprising such peptidomimetics are provided. The peptidomimetics have a three-dimensional structure that is substantially similar to a three-dimensional structure of a cyclic peptide that comprises a cadherin cell adhesion recognition sequence HAV. Methods for using such peptidomimetics for modulating cadherin-mediated cell adhesion in a variety of contexts are also provided.
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  申请人：Hidaka Chisa

  公开号：US20080260829A1

  公开（公告）日：2008-10-23

  This invention relates to BMP fusion genes, BMP fusion proteins. The invention further relates to methods for treatment using BMP fusion genes and BMP fusion proteins. Additionally, the invention relates to BMP fusion gene and BMP fusion protein pharmaceutical compositions.