二氯己酰草胺 | 2533-89-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 二氯己酰草胺
• 中文别名: N-(3,4-二氯苯基)-2-甲基戊酰胺草克尔甲戊酰胺
• 英文名称: N-(3,4-dichlorophenyl)-2-methylpentanamide
• 英文别名: Karsil
• CAS: 2533-89-3
• 化学式: C₁₂H₁₅Cl₂NO
• mdl: MFCD01675574
• 分子量: 260.163
• InChiKey: VUNCGGHZBFQRPB-UHFFFAOYSA-N

物化性质

• 熔点：
  106-107°
• 稳定性/保质期：
  燃烧会产生有毒的氮氧化物和氯化物气体。

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2924299017

制备方法与用途

类别：农药

毒性分级：低毒

急性毒性：

• 口服 - 大鼠 LD50: 10,000 毫克/公斤

可燃性危险特性： 燃烧时产生有毒的氮氧化物和氯化物气体

储运特性：

• 库房需通风、低温干燥
• 与食品原料分开储存和运输

灭火剂：干粉、泡沫、砂土

反应信息

• 作为产物：
  描述：

  2-甲基戊酸 、 3,4-二氯苯胺 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.17h， 以62%的产率得到二氯己酰草胺
  参考文献：
  名称：

  神经酰胺酶小分子抑制剂的发现及其作用机制**

  摘要：

  使用合成荧光神经酰胺分子可以发现第一个选择性药物样小分子碱性神经酰胺酶 3 抑制剂，碱性神经酰胺酶 3 是一种参与健康和疾病中鞘脂代谢的膜内酶。这些抑制剂代表了利用靶向构象动态膜蛋白的类药物小分子控制脂质代谢的新范例。

  DOI：

  10.1002/anie.202109967

文献信息

• Production of aryl acylamidases
  申请人：The Public Health Laboratory Service Board

  公开号：EP0053890A1

  公开（公告）日：1982-06-16

  A process for the production of an aryl acylamidase enzyme involves culturing bacteria of one of the strains Pseudomonas fluorescens ATCC 39005 (or suitable mutants or variants thereof) or Pseudomonas putida ATCC 39004 (or suitable mutants or variants thereof) in a culture medium in which the bacterial strains produce aryl acylamidase and collecting the enzyme containing material, generally the cell material. Preferably the resulting cells are then disrupted, especially by enzymatic treatment, and the aryl acylamidase is separated from the other unwanted substances, generally the other cell constituents. Preferably the culture medium contains N - acylaniline, especially N - acetyl aniline. The N - acylaniline may form part of a complex or defined salts medium.

  生产芳基酰氨基酶的工艺包括在培养基中培养荧光假单胞菌 ATCC 39005 株（或其适当的突变体或变种）或腐生假单胞菌 ATCC 39004 株（或其适当的突变体或变种）中的一种菌株的细菌，在培养基中细菌菌株产生芳基酰氨基酶，并收集含酶物质，通常是细胞物质。最好将得到的细胞破碎，特别是通过酶处理，然后将芳基酰氨基酶与其他不需要的物质（一般是其他细胞成分）分离。 培养基中最好含有 N-酰基苯胺，尤其是 N-乙酰苯胺。N -酰基苯胺可构成复合培养基或定义盐培养基的一部分。
• N-(3-chloro-4-isopropylphenyl)carboxamides, process for producing them, and selective herbicides containing them
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0205271A1

  公开（公告）日：1986-12-17

  An N-(3-chloro-4-isopropylphenyl)carboxamide derivative represented by the general formula wherein R represents a 1-methylbutyl, 1-methylcyclopropyl or cyclopropyl group. This derivative is useful as a selective herbicide, and can be pro- duced by reacting 3-chloro-4-isopropylaniline with a carboxylic acid halide derivative of the general formula wherein R is as defined above and X represents halogen, or with a carboxylic acid anhydride of the general formula wherein R is as defined above.

  由通式代表的 N-(3-氯-4-异丙基苯基)甲酰胺衍生物 其中 R 代表 1-甲基丁基、1-甲基环丙基或环丙基。这种衍生物可用作选择性除草剂，可通过将 3-氯-4-异丙基苯胺与通式如下的羧酸卤化物衍生物反应制得 其中 R 如上文所定义，X 代表卤素，或与通式的羧酸酸酐反应 其中 R 如上定义。
• Pyridyloxypyrimidine derivatives, preparation process thereof, and herbicidal compositions containing the same as active ingredients
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0435186A2

  公开（公告）日：1991-07-03

  Pyridyloxypyrimidine derivatives represented by the following formula [I]: wherein R means a formyl group or an acetal group represented by R¹ and R² being the same or different and individually denoting an alkyl group having 1-4 carbon atoms or R¹ and R² being coupled together and denoting an alkylene group, R³, having 2-3 carbon atoms; preparation processes of the derivatives; and herbicidal compositions containing one or more of the derivatives as an active ingredient.

  下式[I]代表的吡啶氧基嘧啶衍生物： 其中 R 指甲酰基团或乙缩醛基团，其代表为 R¹和R²相同或不同，单独表示具有1-4个碳原子的烷基，或R¹和R²连接在一起，表示具有2-3个碳原子的亚烷基R³；衍生物的制备工艺；以及含有一种或多种衍生物作为活性成分的除草组合物。
• New strains of Drechslera spp., and weed control agents and weed control compositions containing the same
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0464416A2

  公开（公告）日：1992-01-08

  Described are new strains of Drechslera spp., which possess herbicidal effects against all varieties of barnyard grass, i.e., Echinochloa spp. as weed but do not give any influence to crops under cultivation such as rice. Weed control agents according to the present invention, which contain one or more of the novel strains, have high safety and selectivity, thereby providing practical control effects against barnyard grass. Weed control compositions according to the present invention, which contain one or more of the new strains in combination with one or more chemical herbicides, have sufficient herbicidal effects even at dosages which are too low to permit control of weeds when they are applied singly, thereby making it possible to reduce the dosage of herbicides. The weed control compositions can therefore contribute to the prevention of environmental pollution and the occurrence of weeds with acquired pesticide resistance.

  本发明描述了 Drechslera 属的新菌株，它们对所有品种的稗草（即作为杂草的 Echinochloa 属）都具有除草效果，但不会对水稻等栽培作物造成任何影响。根据本发明的杂草控制剂含有一种或多种新型菌株，具有很高的安全性和选择性，因此对稗草具有实际的控制效果。根据本发明的除草组合物含有一种或多种新菌株，并与一种或多种化学除草剂结合使用，具有足够的除草效果，即使在单独使用时，由于剂量太低而无法控制杂草，从而可以减少除草剂的用量。因此，这种除草组合物有助于防止环境污染和获得性抗药性杂草的出现。
• USE OF ENREROCOCCUS FAECIUM STRAINS FOR CURING HEPATIC INSUFFICIENCY AND FOR REGENERATING AND INTENSIFYING METABOLISM IN A LIVER
  申请人：Obschestvo S Ogranichennoi Otvetstvennostyu Alef- Farma

  公开号：EP1666050A1

  公开（公告）日：2006-06-07

  The invention relates to the use of enterococcus faecium (VKPM B-3490) and enterococcus faecium M-3185 (VKPM B-349i) strains, a composition and a Bilaktin preparation based on said stains for curing a hepatic insufficiency which is exhibited by hepatodepressive, cytolytic and cholestatic syndromes and by intrahepatic portal hypertension during hepatic diseases and liver injury, for liver regeneration, preventing overstress in extreme environment conditions, for improving the aerobic productivity of an organism, for increasing a lipid participation in energy supply and for improving correlation between a muscle and fatty mass. Said invention also relates to a method for treating and preventing a hepatic insufficiency exhibited by hepatodepressive, cytolytic and cholestatic syndromes and by intrahepatic portal hypertension during hepatic diseases and liver injury and to a method for improving the aerobic productivity of an organism, for increasing a lipid participation in energy supply and for improving the relation between a muscle and fatty mass.

  本发明涉及粪肠球菌（VKPM B-3490）和粪肠球菌 M-3185（VKPM B-349i）菌株、基于上述染色剂的组合物和 Bilaktin 制剂在治疗肝功能不全方面的用途、细胞溶解和胆汁淤积综合征以及肝病和肝损伤时肝内门静脉高压症所表现的肝功能不全，用于肝脏再生，防止极端环境条件下的过度应激，提高生物体的有氧生产率，增加脂质在能量供应中的参与，以及改善肌肉和脂肪量之间的相关性。本发明还涉及一种治疗和预防肝病和肝损伤期间的肝郁、细胞溶解和胆汁淤积综合征以及肝内门静脉高压症所表现的肝功能不全的方法，以及一种提高机体有氧生产率、增加脂质参与能量供应和改善肌肉与脂肪量之间关系的方法。