4-(2,3,4,5,6-pentafluorophenylthio)-1,2-dimethoxybenzene

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-(2,3,4,5,6-pentafluorophenylthio)-1,2-dimethoxybenzene
• 英文别名: 1-(3,4-Dimethoxyphenyl)sulfanyl-2,3,4,5,6-pentafluorobenzene
• 化学式: C₁₄H₉F₅O₂S
• 分子量: 336.282
• InChiKey: LLLGTNJJMZZMNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  43.8
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2,3,5,6-Tetramethyl-4-(2,3,4,5,6-pentafluorophenyl)sulfinylphenol 在 三氟甲磺酸三甲基硅酯 作用下， 以 乙腈 为溶剂， 反应 0.17h， 生成 4-(2,3,4,5,6-pentafluorophenylthio)-1,2-dimethoxybenzene
  参考文献：
  名称：

  An efficient sulfenylation of aromatics using highly active quinone mono O , S -acetal bearing a pentafluorophenylthio group

  摘要：

  A facile sulfenylation of various aromatic nuclei was achieved by use of the novel sulfenylation reagent, the quinone mono O,S-acetal bearing a pentafluorophenylthio group. This reagent functions below 0 degreesC in the presence of a catalytic amount of TMSOTf. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)02186-9

文献信息

• Benzene compounds as antiproliferative and cholesterol lowering agents
  申请人：——

  公开号：US20020013496A1

  公开（公告）日：2002-01-31

  The invention provides compounds, compositions and methods relating to novel electrophilic aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of the general Formula I: 1

  本发明提供了与新型亲电芳香衍生物相关的化合物、组合物和方法，以及它们作为药理活性剂的用途。这些组合物特别适用于治疗疾病状态，特别是癌症、银屑病、血管再狭窄、感染、动脉粥样硬化和高胆固醇血症，或作为这些剂的开发的先导化合物。这些组合物包括通式I的化合物：1。
• Facile and Efficient Sulfenylation Method Using Quinone Mono-<i>O,S</i>-Acetals under Mild Conditions
  作者：Masato Matsugi、Kenji Murata、Kentoku Gotanda、Hisanori Nambu、Gopinathan Anilkumar、Keita Matsumoto、Yasuyuki Kita

  DOI：10.1021/jo001710q

  日期：2001.4.1

  A novel sulfenylation method induced by aromatization of quinone mono-O,S-acetals is described. These sulfenylation reagents readily react with silyl enolethers or electron rich aromatic compounds to give sulfenylation products under mild conditions. In particular, O,S-acetal 2j, which possesses a pentafluorophenylthio function, is the most effective reagent from the standpoint of the adaptability for various substrates.
• SUBSTITUTED BENZENE COMPOUNDS AS ANTIPROLIFERATIVE AND CHOLESTEROL LOWERING AGENTS
  申请人：TULARIK, INC.

  公开号：EP1005453A1

  公开（公告）日：2000-06-07
• [EN] SUBSTITUTED BENZENE COMPOUNDS AS ANTIPROLIFERATIVE AND CHOLESTEROL LOWERING AGENTS<br/>[FR] COMPOSES A SUBSTITUTION BENZENIQUE, AGENTS ANTIPROLIFERATIFS ET REDUCTEUR DU CHOLESTEROL
  申请人：——

  公开号：WO1999010320A1

  公开（公告）日：1999-03-04

  [EN] The invention provides compounds, compositions and methods relating to novel electrophilic aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of general Formula (I).
  [FR] L'invention porte sur des composés, compositions et procédés relatifs à de nouveaux dérivés aromatiques électrophiles et leur utilisation comme agents pharmacologiques actifs pouvant traiter des états morbides tels qu'en particulier le cancer, le psoriasis, les resténoses vasculaires, les infections, l'athérosclérose ou l'hypercholestérolémie, ou sur leurs précurseurs. Lesdites compositions renferment des composés de formule générale (I).