di-(2,5-dimethoxyphenyl)sulfoxide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: di-(2,5-dimethoxyphenyl)sulfoxide
• 英文别名: bis-(2,5-dimethoxy-phenyl)-sulfoxide；Bis-(2,5-dimethoxy-phenyl)-sulfoxid；2.5.2'.5'-Tetramethoxy-diphenylsulfoxyd；2-(2,5-Dimethoxyphenyl)sulfinyl-1,4-dimethoxybenzene
• 化学式: C₁₆H₁₈O₅S
• 分子量: 322.382
• InChiKey: GJVSVOYPRPLLQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  73.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  对苯二甲醚 在 氯化亚砜 、 scandium tris(trifluoromethanesulfonate) 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 以95%的产率得到di-(2,5-dimethoxyphenyl)sulfoxide
  参考文献：
  名称：

  Scandium Triflate Catalyzed One-Pot Synthesis of Diaryl Sulfoxides

  摘要：

  芳烃在室温下与氯磺酰反应，且在催化量的三氟化钪存在下，顺利生成相应的对称二芳基亚砜，产率极高，区域选择性良好。

  DOI：

  10.1055/s-2002-25330

文献信息

• Scandium Triflate Catalyzed One-Pot Synthesis of Diaryl Sulfoxides
  作者：Jhillu S. Yadav、Basi V. Subba Reddy、R. Srinivasa Rao、S. Praveen Kumar、K. Nagaiah

  DOI：10.1055/s-2002-25330

  日期：——

  Arenes react smoothly with thionyl chloride in the presence of a catalytic amount of scandium triflate at ambient temperature to afford the corresponding symmetrical diaryl sulfoxides in excellent yields with high regioselectivity.

  芳烃在室温下与氯磺酰反应，且在催化量的三氟化钪存在下，顺利生成相应的对称二芳基亚砜，产率极高，区域选择性良好。
• Highly Rapid and Direct Synthesis of Diaryl Sulfoxides
  作者：B. P. Bandgar、S. N. Kinkar、V. T. Kamble、S. V. Bettigeri

  DOI：10.1055/s-2003-41461

  日期：——

  Aromatic compounds react smoothly with thionyl chloride in the presence of 10 mol% of water at ambient temperature to afford the corresponding symmetrical diaryl sulfoxides in good to excellent yields with high regioselectivity.

  芳香化合物在常温下与10 mol%的水共同存在时，能与亚硫酰氯顺利反应，得到相应的对称二芳基亚砜，产率良好至优异，并且具有高的区域选择性。
• Impact of Ambulance Diversion Policies in Urban, Suburban, and Rural Areas of Central Maryland
  作者：James J. Scheulen、Guohua Li、Gabor D. Kelen

  DOI：10.1111/j.1553-2712.2001.tb00546.x

  日期：2001.1

  Abstract. As a method to control patient flow to overburdened hospitals, effective emergency medical services (EMS) systems provide policies for ambulance diversion. The Maryland state EMS system supports two types of alert for general hospital use: red alert, aimed at limiting the delivery of patients who may require intensive care unit (ICU) admission, and yellow alert, aimed at preventing further overload of already overtaxed emergency departments (EDs). Objective: To examine the effect of those alert policies in different geographical environments, urban, suburban, and rural. Methods: Alert data for 23 hospitals in Central Maryland and ambulance arrival data for approximately 138,000 ambulance calls during calendar year 1996 were combined and analyzed. The impacts of diversion practices in the geographic areas were compared. Results: Red alert reduced volume in all patient acuity levels in all geographic areas by a statistically significant 0.4 patient/hr. Yellow alert diverted low‐acuity patients at the rate of 0.13 patient/hr (p < 0.001) in urban areas and at the rate of 0.16 patient/hr (p < 0.001) in suburban areas, but had minimal impact in the flow of patients in the rural environment. Conclusions: The ED diversion policy has some limited effect in preventing further patient volume in urban and suburban areas, but has virtually no impact in rural areas. However, an ICU diversion policy diverts patients of all acuities uniformly and inordinately diverts patients not likely to require ICU admissions while having only minimal impact on patients who do require ICU resources. The impact of red alert is uniform in all geographic areas. The impact and efficacy of ambulance diversion policies should be evaluated to ensure they are having the intended effect. While perhaps initially effective, the impact of alert policies may change over time.
• Grignard; Zorn, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1910, vol. 150, p. 1179
  作者：Grignard、Zorn

  DOI：——

  日期：——
• Lithium/Sodium Perchlorate Catalyzed Synthesis of Symmetrical Diaryl Sulfoxides
  作者：B. P. Bandgar、S. S. Makone

  DOI：10.1081/scc-120027723

  日期：2004.12.31

  Synthesis of diaryl sulfoxides from aromatics and thionyl chloride catalyzed by LiClO4/NaClO4 at room temperature is described. Mild reaction conditions, simple work-up, inexpensive and easily available catalysts are important and attractive features of this method.