N-isopentylbenzo[d]thiazol-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: N-isopentylbenzo[d]thiazol-2-amine
• 英文别名: N-(3-methylbutyl)-1,3-benzothiazol-2-amine
• 化学式: C₁₂H₁₆N₂S
• mdl: MFCD11115233
• 分子量: 220.338
• InChiKey: SISADGXSXNACGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  53.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨基苯并噻唑 、 异戊醇 在 bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] 、 sodium hydroxide 作用下， 反应 12.0h， 以97%的产率得到N-isopentylbenzo[d]thiazol-2-amine
  参考文献：
  名称：

  铱配合物/碱体系催化氨基醇直接与醇进行N-烷基化反应。

  摘要：

  通过铱络合物/碱体系已经实现了使用各种醇作为烷基化剂以良好的至优异的产率将氨基唑直接和区域选择性地将N-烷基化为相应的2-N-（烷基氨基）唑。

  DOI：

  10.1039/c1cc14861c

文献信息

• METHOD FOR PRODUCING 2-HYDRAZINOBENZOTHIAZOLE DERIVATIVE
  申请人：DIC Corporation

  公开号：US20200165215A1

  公开（公告）日：2020-05-28

  The present invention provides a novel method for producing a 2-hydrazinobenzothiazole derivative. The present invention also provides a method for producing a compound by using the 2-hydrazinobenzothiazole derivative obtained by the production method, and a composition that contains the compound. The present invention also provides a polymerizable composition that is useful in producing film-shaped polymers and contains the compound obtained by the production method. The invention of the present application provides a method for producing a compound represented by general formula (I-C), the method including a step of reacting a compound represented by general formula (I-B) with a compound represented by general formula (I-A) in the presence of at least one compound selected from the group consisting of metal amides, metal hydrides, metal alkoxides, and organic alkali metals. A compound derived from the compound produced by the production method, and a composition that contains the compound are also provided.

  本发明提供一种生产2-联苯并噻唑酮衍生物的新方法。本发明还提供一种通过使用通过生产方法获得的2-联苯并噻唑酮衍生物生产化合物的方法，以及含有该化合物的组合物。本发明还提供一种可用于生产膜状聚合物的可聚合组合物，其中包含通过生产方法获得的化合物。本申请的发明提供了一种生产通式(I-C)所代表的化合物的方法，该方法包括在至少选择自金属胺、金属氢化物、金属烷氧化物和有机碱金属组成的群体中，通过将通式(I-B)所代表的化合物与通式(I-A)所代表的化合物在存在下反应的步骤。还提供了通过生产方法产生的化合物衍生物以及含有该化合物的组合物。
• POLYMERIZABLE COMPOUND AND OPTICAL ISOMER
  申请人：DIC Corporation

  公开号：US20180022716A1

  公开（公告）日：2018-01-25

  The present invention provides a polymerizable compound having high storage stability without causing crystal precipitation when added to a polymerizable composition. The present invention also provides a polymerizable composition containing the compound. When the filmy polymer produced through polymerization of the polymerizable composition is irradiated with UV light, it hardly discolors or peels from substrate. Further, the present invention provides a polymer produced through polymerization of the polymerizable composition and an optically anisotropic body using the polymer.

  本发明提供了一种聚合物化合物，具有高储存稳定性，添加到聚合物化合物时不会导致结晶沉淀。本发明还提供了含有该化合物的聚合物化合物。当通过聚合物化合物的聚合产生薄膜状聚合物时，若用紫外光照射，它几乎不会变色或脱落。此外，本发明提供了通过聚合物化合物的聚合产生的聚合物，以及使用该聚合物的光学各向异性体。
• Laccase-Catalysed Homocoupling of Primary Aromatic Amines towards the Biosynthesis of Dyes
  作者：Ana Catarina Sousa、Lígia O. Martins、M. Paula Robalo

  DOI：10.1002/adsc.201300501

  日期：2013.10.11

  AbstractColoured disubstituted benzoquinonimine trimeric structures are obtained as main reaction products of the oxidation of p‐electron donor primary aromatic amines using two different laccases, CotA‐laccase from Baccilus subtilus and TvL from Trametes versicolor. These orange‐red to purple products, presenting high molar extinction coefficients, presumably result from oxidative homocoupling reactions, through the formation of NC bonds at positions 2 and 5, of the laccase oxidised intermediate as showed in the proposed oxidative pathway. The product of 1,4‐phenylenediamine is shown to be the trimer known as Bandrowski’s base which has an established role in hair and fur dyeing. Our results also show that the occurrence and/or rates of oxidation of aromatic amines are strongly dependent on the presence of p‐electron releasing substituents in the aromatic ring and are independent on the properties of the enzyme used. Overall our data contribute for (i) understanding key features of laccase reactivity with p‐substituted aromatic amines and (ii) establishing enzymatic processes that lead to the synthesis of coloured bio‐products under mild conditions with potential impact in the cosmetic and dye industries.magnified image
• Convenient and Reliable Routes Towards 2-Aminothiazoles: Palladium-Catalyzed<i>versus</i>Copper-Catalyzed Aminations of Halothiazoles
  作者：Stéphanie Toulot、Timo Heinrich、Frédéric R. Leroux

  DOI：10.1002/adsc.201300591

  日期：2013.11.11

  AbstractTwo efficient methods for the amination of 2‐halothiazoles are presented here. A first protocol requires a Pd/L system. Several 2‐aminothiazoles were synthesized under optimized conditions and isolated in good yields. The first palladium‐catalyzed CN coupling reactions between 2‐halothiazoles and primary alkylamines are presented. In a second part, ligand‐free copper‐catalyzed aminations of 2‐halothiazoles by alkylamines and aniline in a green solvent have been developed. The protocol is very effective for primary and secondary amines and perfectly tolerates the presence of another halide moiety on the 2‐halothiazole. The reaction occurs under the assistance of microwave irradiation, which drastically decreases the reaction time. The reaction leads to the formation of 2‐aminothiazoles, key molecules in pharmaceutical research.magnified image
• 4-(1H-2-METHYLIMIDAZO 4,5-c]PYRIDINYLMETHYL)PHENYLSULPHONAMIDE DERIVATIVES AS ANTAGONISTS OF PAF
  申请人：BRITISH BIO-TECHNOLOGY LIMITED

  公开号：EP0635018A1

  公开（公告）日：1995-01-25