1-amino-1-phenyl-2-(2'-pyrazinyl)ethylene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-amino-1-phenyl-2-(2'-pyrazinyl)ethylene
• 英文别名: 1-Phenyl-2-pyrazin-2-ylethenamine；1-phenyl-2-pyrazin-2-ylethenamine
• 化学式: C₁₂H₁₁N₃
• 分子量: 197.239
• InChiKey: BSRNCGAEFQFCMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-amino-1-phenyl-2-(2'-pyrazinyl)ethylene 在 lead(IV) acetate 作用下， 以 乙腈 为溶剂， 反应 0.25h， 以90%的产率得到1H-2,5-diphenyl-3,4-dipyrazinylpyrrole
  参考文献：
  名称：

  Preparation of 1H-2,3,4,5-Tetraarylpyrroles by oxidation of heterocyclic imine-enamines

  摘要：

  Heterocyclic imine-enamines 1 were prepared from metalated methyl substituted heterocycles and aromatic nitriles and then oxidized with lead tetracetate to give various tetraarylpyrroles 2.

  DOI：

  10.1080/00397919608086755
• 作为产物：
  描述：

  2-甲基吡嗪 、 苯甲腈 在 lithium diisopropyl amide 作用下， 生成 1-amino-1-phenyl-2-(2'-pyrazinyl)ethylene
  参考文献：
  名称：

  Preparation of 1H-2,3,4,5-Tetraarylpyrroles by oxidation of heterocyclic imine-enamines

  摘要：

  Heterocyclic imine-enamines 1 were prepared from metalated methyl substituted heterocycles and aromatic nitriles and then oxidized with lead tetracetate to give various tetraarylpyrroles 2.

  DOI：

  10.1080/00397919608086755

文献信息

• Aloisines, a New Family of CDK/GSK-3 Inhibitors. SAR Study, Crystal Structure in Complex with CDK2, Enzyme Selectivity, and Cellular Effects
  作者：Yvette Mettey、Marie Gompel、Virginie Thomas、Matthieu Garnier、Maryse Leost、Irène Ceballos-Picot、Martin Noble、Jane Endicott、Jean-michel Vierfond、Laurent Meijer

  DOI：10.1021/jm020319p

  日期：2003.1.1

  Cyclin-dependent kinases (CDKs) regulate the cell cycle, apoptosis, neuronal functions, transcription, and exocytosis. The observation of CDK deregulations in various pathological situations suggests that CDK inhibitors may have a therapeutic value. In this article, we report on the identification of 6-phenyl[5H]pyrrolo[2,3-b]pyrazines (aloisines) as a novel potent CDK inhibitory scaffold. A selectivity study performed on 26 kinases shows that aloisine A is highly selective for CDK1/cyclin B, CDK2/cyclin A-E, CDK5/p25, and GSK-3alpha/beta; the two latter enzymes have been implicated in Alzheimer's disease. Kinetic studies, as well as the resolution of a CDK2-aloisine cocrystal structure, demonstrate that aloisines act by competitive inhibition of ATP binding to the catalytic subunit of the kinase. As observed with all inhibitors reported so far, aloisine interacts with the ATP-binding pocket through two hydrogen bonds with backbone nitrogen and oxygen atoms of Leu 83. Aloisine inhibits cell proliferation by arresting cells in both G1 and G2.