3-hydroxymethyltetrahydropyran-2-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 3-hydroxymethyltetrahydropyran-2-ol
• 英文别名: 3-(Hydroxymethyl)oxan-2-ol
• 化学式: C₆H₁₂O₃
• 分子量: 132.159
• InChiKey: RYGAPPOIQFXKRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  pent-2-ene-1,5-diol 、 一氧化碳 在 chloro(1,5-cyclooctadiene)rhodium(I) dimer 氢气 、 三苯基膦 作用下， 以 1,4-二氧六环 为溶剂， 120.0 ℃ 、6.0 MPa 条件下， 反应 20.0h， 以35%的产率得到2,3,3aβ,4,5,6aβ-perhydrofuro<2,3b>furan
  参考文献：
  名称：

  Synthesis of Furo[2,3b]furans and Furo[2,3b]pyrans via Rhodium-Catalyzed Tandem Hydroformylation/Acetalization

  摘要：

  GRAPHICSRhodium-catalyzed tandem hydroformylation/acetalization of alpha,omega-alkenediols gives facile access to perhydrofuro[2,3b]furans and perhydrofuro[2,3b]pyrans in good yields. Similarly, benzoannelated tetrahydrofuro[2,3b]furans are obtained by hydroformylation of o-hydroxy cinnamyl alcohols.

  DOI：

  10.1021/ol017083o

文献信息

• PROCESS FOR SPLITTING WATER-SOLUBLE ETHERS
  申请人：——

  公开号：US20030187308A1

  公开（公告）日：2003-10-02

  A process for production of 1,3-propanediol including the steps: (a) hydrating acrolein in the presence of an acid hydration catalyst; (b) catalytically hydrogenating the reaction mixture of step (a), which reaction mixture comprises 3-hydroxypropionaldehyde and is freed of unreacted acrolein; (c) refining the reaction mixture of step (b) containing water, 1,3-propanediol and the by-products boiling higher than 1,3-propanediol; and (d) treating 4-oxa-1,7-heptanediol to form 1,3-propanediol by (1) removing a boiler sump comprising 4-oxa-1,7-heptanediol from the refining step (c), (2) treating the boiler sump in an aqueous solution in the presence of an acid catalyst at about 200 to about 300° C. to form a solution comprising 1,3-propanediol, (3) neutralizing the solution obtained is step (2), and returning the neutralized solution from step (3) to the refining step (c). In addition, a process for splitting oligomeric water-soluble ether comprising: (a) treating an aqueous solution comprising oligomeric water-soluble ether in the presence of homogeneous acid catalyst at a temperature of from about 200 to about 300 ° C. to form the monomer of the oligomeric water-soluble ether; and (b) neutralizing the solution obtained in step (a),

  生产1,3-丙二醇的过程包括以下步骤：(a) 在酸性水合催化剂存在下水合丙烯醛；(b) 在步骤(a)的反应混合物中进行催化加氢，该反应混合物包括3-羟基丙醛并且除去未反应的丙烯醛；(c) 精制步骤(b)的反应混合物，其中包含水、1,3-丙二醇和沸点高于1,3-丙二醇的副产物；以及(d) 通过处理4-氧杂-1,7-庚二醇来形成1,3-丙二醇，方法为：(1) 从精制步骤(c)中去除包含4-氧杂-1,7-庚二醇的锅炉底液，(2) 在酸性催化剂存在下，在约200至约300°C的水溶液中处理锅炉底液以形成包含1,3-丙二醇的溶液，(3) 中和步骤(2)中获得的溶液，并将从步骤(3)中中和的溶液返回到精制步骤(c)。此外，还包括一种分解寡聚水溶性醚的过程，包括：(a) 在均相酸性催化剂存在下处理含有寡聚水溶性醚的水溶液，在约200至约300°C的温度下形成寡聚水溶性醚的单体；以及(b) 中和步骤(a)中获得的溶液。
• US6693222B2
  申请人：——

  公开号：US6693222B2

  公开（公告）日：2004-02-17
• Synthesis of Furo[2,3<i>b</i>]furans and Furo[2,3<i>b</i>]pyrans via Rhodium-Catalyzed Tandem Hydroformylation/Acetalization
  作者：Rafael Roggenbuck、Andreas Schmidt、Peter Eilbracht

  DOI：10.1021/ol017083o

  日期：2002.1.1

  GRAPHICSRhodium-catalyzed tandem hydroformylation/acetalization of alpha,omega-alkenediols gives facile access to perhydrofuro[2,3b]furans and perhydrofuro[2,3b]pyrans in good yields. Similarly, benzoannelated tetrahydrofuro[2,3b]furans are obtained by hydroformylation of o-hydroxy cinnamyl alcohols.