(1S,2S)-(-)-N1,N2-bis[1-(4-methylphenyl)ethyl]-1,2-propanediimine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1S,2S)-(-)-N1,N2-bis[1-(4-methylphenyl)ethyl]-1,2-propanediimine
• 英文别名: 1-N,2-N-bis[(1S)-1-(4-methylphenyl)ethyl]propane-1,2-diimine
• 化学式: C₂₁H₂₆N₂
• 分子量: 306.451
• InChiKey: IYRBBEYGEJQEJJ-OALUTQOASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  24.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  dichloro(cycloocta-1,5-diene)palladium (II) 、 (1S,2S)-(-)-N1,N2-bis[1-(4-methylphenyl)ethyl]-1,2-propanediimine 以 苯 为溶剂， 以97%的产率得到cis-[(1S,2S)-(-)-N1,N2-bis[1-(4-methylphenyl)ethyl]-1,2-propanediimine]dichloropalladium(II)
  参考文献：
  名称：

  Vazquez, Jaime; Berns, Sylvain; Sharma, Pankaj, Polyhedron, 2011, vol. 30, p. 2514 - 2522

  摘要：

  DOI：
• 作为产物：
  描述：

  (S)-1-(4-甲基苯基)乙胺 、 丙酮醛 在 sodium sulfate 作用下， 以 乙醚 、 水 为溶剂， 反应 24.0h， 以94%的产率得到(1S,2S)-(-)-N1,N2-bis[1-(4-methylphenyl)ethyl]-1,2-propanediimine
  参考文献：
  名称：

  Synthesis, characterization and anticancer activity of new chiral Pd(II)-complexes derived from unsymmetrical α-diimine ligands

  摘要：

  A set of new diastereopure unsymmetrical alpha-diimine ligands 2a-d derived from methylglyoxal and optically pure primary amines 1a-d afforded the new chiral Pd(II)-complexes (S,S)-3a, (S,S)-3b, (S,S)-3c, and (1S, 2S, 3S, 5R)-3d. All compounds have been characterized by IR, H-1, and C-13 NMR spectroscopies along with MS-FAB(+) spectrometry. The crystal and molecular structure for the complexes 3a, 3b and 3d have been fully confirmed by single-crystal X-ray studies. Likewise, complexes 3a-d have also been screened for their in vitro cytotoxicity against different classes of cancer: leukemia (K-562 CML), colon cancer (HCT-15), human breast adenocarcinoma (MCF-7), central nervous system (U-251 Glio) and prostate cancer (PC-3) cell lines. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2011.06.020

文献信息

• Synthesis, characterization and anticancer activity of new chiral Pd(II)-complexes derived from unsymmetrical α-diimine ligands
  作者：Jaime Vázquez、Sylvain Bernès、Pankaj Sharma、Javier Pérez、Guadalupe Hernández、Alejandra Tovar、Ulises Peña、René Gutiérrez

  DOI：10.1016/j.poly.2011.06.020

  日期：2011.9

  A set of new diastereopure unsymmetrical alpha-diimine ligands 2a-d derived from methylglyoxal and optically pure primary amines 1a-d afforded the new chiral Pd(II)-complexes (S,S)-3a, (S,S)-3b, (S,S)-3c, and (1S, 2S, 3S, 5R)-3d. All compounds have been characterized by IR, H-1, and C-13 NMR spectroscopies along with MS-FAB(+) spectrometry. The crystal and molecular structure for the complexes 3a, 3b and 3d have been fully confirmed by single-crystal X-ray studies. Likewise, complexes 3a-d have also been screened for their in vitro cytotoxicity against different classes of cancer: leukemia (K-562 CML), colon cancer (HCT-15), human breast adenocarcinoma (MCF-7), central nervous system (U-251 Glio) and prostate cancer (PC-3) cell lines. (C) 2011 Elsevier Ltd. All rights reserved.
• Vazquez, Jaime; Berns, Sylvain; Sharma, Pankaj, Polyhedron, 2011, vol. 30, p. 2514 - 2522
  作者：Vazquez, Jaime、Berns, Sylvain、Sharma, Pankaj、Perez, Javier、Hernandez, Guadalupe、et al.

  DOI：——

  日期：——