5-((2-acetoxybenzoyl)oxy)pentyl 2-oxo-2H-chromene-3-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-((2-acetoxybenzoyl)oxy)pentyl 2-oxo-2H-chromene-3-carboxylate
• 英文别名: 5-(2-Acetyloxybenzoyl)oxypentyl 2-oxochromene-3-carboxylate；5-(2-acetyloxybenzoyl)oxypentyl 2-oxochromene-3-carboxylate
• 化学式: C₂₄H₂₂O₈
• 分子量: 438.434
• InChiKey: GJPTVOVJBVPPJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  32
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  香豆素-3-羧酸 在 二乙胺 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 14.0h， 生成 5-((2-acetoxybenzoyl)oxy)pentyl 2-oxo-2H-chromene-3-carboxylate
  参考文献：
  名称：

  Synthesis and Biological Evaluation of Novel Coumarin Derivatives as Antiplatelet Agents

  摘要：

  In order to develop anti-thrombotic agents with higher potency, a series of novel coumarin derivatives (5a-m) were designed, synthesized and biologically evaluated. Compound 5e displayed the strongest activity in inhibiting the adenosine diphosphate (ADP)-induced platelet aggregation in vitro, with 2.3-fold more effectiveness than clinically used antiplatelet drug aspirin (ASP). Thus, Compound 5e could deserve further investigations as antiplatelet agents.

  DOI：

  10.3987/com-15-13342

文献信息

• Synthesis and Biological Evaluation of Novel Coumarin Derivatives as Antiplatelet Agents
  作者：Li-Qin He、Peng Huang、Lei-Lei Gao、Zhuo Zhang、Jing-Ru Liu

  DOI：10.3987/com-15-13342

  日期：——

  In order to develop anti-thrombotic agents with higher potency, a series of novel coumarin derivatives (5a-m) were designed, synthesized and biologically evaluated. Compound 5e displayed the strongest activity in inhibiting the adenosine diphosphate (ADP)-induced platelet aggregation in vitro, with 2.3-fold more effectiveness than clinically used antiplatelet drug aspirin (ASP). Thus, Compound 5e could deserve further investigations as antiplatelet agents.