methyl (E,S)-2,5-bis(4-methoxyphenyl)pent-4-enoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: methyl (E,S)-2,5-bis(4-methoxyphenyl)pent-4-enoate
• 英文别名: methyl (E,2S)-2,5-bis(4-methoxyphenyl)pent-4-enoate
• 化学式: C₂₀H₂₂O₄
• 分子量: 326.392
• InChiKey: LQAZCEQQDRPKJN-PXPVJAHISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  methyl 2-diazo-2-(4-methoxypheny)acetate 、 茴香烯 在 Rh₂[(N-(4-dodecylphenyl)sulfonyl)-(S)-prolinate]4 作用下， 以 various solvent(s) 为溶剂， 反应 5.0h， 生成 methyl (E,S)-2,5-bis(4-methoxyphenyl)pent-4-enoate 、 methyl (E,R)-2,5-bis(4-methoxyphenyl)pent-4-enoate 、 (1R,2S,3R)-methyl 1,2-bis(4-methoxyphenyl)-3-methylcyclopropanecarboxylate 、 (1S,2R,3S)-methyl 1,2-bis(4-methoxyphenyl)-3-methylcyclopropanecarboxylate
  参考文献：
  名称：

  Balance between Allylic C−H Activation and Cyclopropanation in the Reactions of Donor/Acceptor-Substituted Rhodium Carbenoids with trans-Alkenes

  摘要：

  Rhodium(II)-catalyzed reactions of aryldiazoacetates with (E)-aryl-substituted alkenes generate C-H insertion products and/or cyclopropanes. The product distribution is influenced by the nature of the donor group on the carbenold, the structure of the (E)-aryl-substituted alkenes, and the rhodium catalyst.

  DOI：

  10.1021/ol702218w

文献信息

• Balance between Allylic C−H Activation and Cyclopropanation in the Reactions of Donor/Acceptor-Substituted Rhodium Carbenoids with <i>trans</i>-Alkenes
  作者：Huw M. L. Davies、Michael G. Coleman、Dominic L. Ventura

  DOI：10.1021/ol702218w

  日期：2007.11.1

  Rhodium(II)-catalyzed reactions of aryldiazoacetates with (E)-aryl-substituted alkenes generate C-H insertion products and/or cyclopropanes. The product distribution is influenced by the nature of the donor group on the carbenold, the structure of the (E)-aryl-substituted alkenes, and the rhodium catalyst.