Tri-n-butyl-(2,3,4-trimethoxyphenyl)stannane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Tri-n-butyl-(2,3,4-trimethoxyphenyl)stannane
• 英文别名: Tributyl(2,3,4-trimethoxyphenyl)stannane；tributyl-(2,3,4-trimethoxyphenyl)stannane
• 化学式: C₂₁H₃₈O₃Sn
• 分子量: 457.241
• InChiKey: SLJOGRFASQNGLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.77
• 重原子数：
  25
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Tri-n-butyl-(2,3,4-trimethoxyphenyl)stannane 在 copper(l) iodide 、 四(三苯基膦)钯 盐酸 、 sodium azide 、 碳酸氢钠 、 三氟乙酸 、 tin(ll) chloride 、 sodium nitrite 作用下， 以 甲醇 、 乙醇 、 乙酸乙酯 为溶剂， 反应 103.42h， 生成 4'-Amino-3'-hydroxy-2,3,4-trimethoxy-1,1'-biphenyl
  参考文献：
  名称：

  Potential Photoaffinity Labels for Tubulin. Synthesis and Evaluation of Diazocyclohexadienone and Azide Analogs of Colchicine, Combretastatin, and 3,4,5-Trimethoxybiphenyl

  摘要：

  Analogs of tubulin assembly inhibitors such as colchicine, combretastatin, and 3,4,5-trimethoxybiphenyl which incorporate a 6-diazo-2,4-cyclohexadienone (o-quinone diazide) ring have been synthesized and characterized. The compounds synthesized include 6-diazo-4-(2',3',4'-trimethoxyphenyl)cyclohexa-2,4-dien-1-one and its 3-methyl and 3-ethyl analogs (1a-c), 6-diazo-3-(2,3,4-trimethoxyphenyl)-2,4-cyclohexadien-1-one and its 4-methyl and 4-ethyl derivatives (2a-c), 4-[Z-2-(3',4',5'-trimethoxyphenyl)ethenyl]-6-diazocyclohexa-2,4-dienone (3), 3-[Z-2-(3',4',5'-trimethoxyphenyl)ethenyl]-6-diazocyclohexa-2,4-dien-1-one (4), the corresponding dihydro derivatives (5, 6) and two isomeric diazocyclohexadienones derived from N-acetylcolchinol (7, 8). Compounds in which the cyclohexadienone oxygen is approximately isostructural with carbonyl or hydroxy functions of the parent compounds exhibit good activity in the tubulin assembly inhibition assay. 2'-Alkyl-4'azido-3,4,5-trimethoxy-1,1'-biphenyls also show good activity as tubulin assembly inhibitors.

  DOI：

  10.1021/jo00094a048

文献信息

• Enantioselective construction of sterically hindered tertiary α-aryl ketones: a catalytic asymmetric synthesis of isoflavanones
  作者：Michael P. Carroll、Helge Müller-Bunz、Patrick J. Guiry

  DOI：10.1039/c2cc36452b

  日期：——

  A method for the catalytic asymmetric alpha-arylation of ketones bearing very sterically hindered aryl rings has been developed. This reaction occurs under mild conditions, in short reaction times and has been applied to the first catalytic asymmetric synthesis of isoflavanones.

  已经开发出一种用于催化具有非常空间受阻的芳基环的酮的催化不对称α-芳基化的方法。该反应在温和的条件下在短的反应时间内发生，并已被用于异黄酮的第一催化不对称合成。