2-(iodomethyl)butanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-(iodomethyl)butanoic acid
• 英文别名: 2-iodomethyl-butyric acid；2-Jodmethyl-buttersaeure
• 化学式: C₅H₉IO₂
• 分子量: 228.03
• InChiKey: JREGFGVDTJQHBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-乙基丙烯酸 在 氢碘酸 作用下， 生成 2-(iodomethyl)butanoic acid
  参考文献：
  名称：

  Blaise; Luttringer, Bulletin de la Societe Chimique de France, 1905, vol. <3> 33, p. 769

  摘要：

  DOI：

文献信息

• A study of the reaction of n-BuLi with Ti(Oi-Pr)4 as a method to generate titanacyclopropane and titanacyclopropene species
  作者：Valentin A. Rassadin、Yvan Six

  DOI：10.1016/j.tet.2013.12.048

  日期：2014.1

  The use of the combination of reagents Ti(Oi-Pr)(4)/n-BuLi, introduced by the group of J.J. Eisch in 2001, has only found a few applications so far, with sometimes conflicting observations. This article describes a study aimed at clarifying the nature, the stability and the reactivity of the active organometallic species involved. Reactions with CO2 and other trapping reagents reveal that it is generated within a few minutes at 0 degrees C in THF, where it can be considered to be stable for 30 min. Most of our results are consistent with the expected titanacyclopropane nature of this reagent but some observations suggest that the chemistry at play may be more complicated. (C) 2013 Elsevier Ltd. All rights reserved.
• Blaise; Luttringer, Bulletin de la Societe Chimique de France, 1905, vol. <3> 33, p. 769
  作者：Blaise、Luttringer

  DOI：——

  日期：——