2,4-diisobutylpyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,4-diisobutylpyrimidine
• 英文别名: 2,4-Bis(2-methylpropyl)pyrimidine；2,4-bis(2-methylpropyl)pyrimidine
• 化学式: C₁₂H₂₀N₂
• 分子量: 192.304
• InChiKey: OAZSMHNGHZIGRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  三异丁基铝 、 2-chloro-4-isobutylpyrimidine 在 四(三苯基膦)钯 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以68%的产率得到2,4-diisobutylpyrimidine
  参考文献：
  名称：

  Trialkylalanes in Palladium-Catalyzed C-Alkylations of Azines.

  摘要：

  Carbo-substitution with alkyl groups in halogenoazines is readily effected under the influence of Pd-catalysis with alanes as the donor of the alkyl group.

  DOI：

  10.3891/acta.chem.scand.51-0302

文献信息

• MODULATION OF COMPLEMENT ACTIVITY
  申请人：Ra Pharmaceuticals, Inc.

  公开号：US20170137468A1

  公开（公告）日：2017-05-18

  The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.
• MODULATORS OF COMPLEMENT ACTIVITY
  申请人：Ra Pharmaceuticals, Inc.

  公开号：US20180021402A1

  公开（公告）日：2018-01-25

  The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.
• ISOQUINOLIDINOBENZODIAZEPINE (IQB)-1(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE (CBI) DIMERS
  申请人：Cellerant Therapeutics, Inc.

  公开号：US20180177795A1

  公开（公告）日：2018-06-28

  Provided herein are isoquinolidinobenzodiazepine (IQB)-1(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimers, antibody-drug conjugates comprising them and methods of use for killing cells and treating disease.
• US9937222B2
  申请人：——

  公开号：US9937222B2

  公开（公告）日：2018-04-10
• Trialkylalanes in Palladium-Catalyzed C-Alkylations of Azines.
  作者：Qingbo Lu、Ionel Mangalagiu、Tore Benneche、Kjell Undheim、Kari Rissanen、Wenjun Shi、Stenbjörn Styring、Cecilia Tommos、Kurt Warncke、Bryan R. Wood

  DOI：10.3891/acta.chem.scand.51-0302

  日期：——

  Carbo-substitution with alkyl groups in halogenoazines is readily effected under the influence of Pd-catalysis with alanes as the donor of the alkyl group.