1-(2,3,5,6-tetrahydroimidazo<2,1-b>thiazol-6-yl)ethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1-(2,3,5,6-tetrahydroimidazo<2,1-b>thiazol-6-yl)ethanone
• 英文别名: 1-(2,3,5,6-Tetrahydroimidazo[2,1-b][1,3]thiazol-6-yl)ethanone
• 化学式: C₇H₁₀N₂OS
• 分子量: 170.235
• InChiKey: PCXWSKWLUXXBHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  58
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(2,3,5,6-tetrahydroimidazo<2,1-b>thiazol-6-yl)ethanone 反应 672.0h， 生成 1-(2,3-dihydroimidazo<2,1-b>thiazol-6-yl)ethanone
  参考文献：
  名称：

  Synthesis of 2,3,5,6-Tetrahydroimidazo[2,1-b]thiazoles

  摘要：

  The reactions of 2-amino-2-thiazoline with alkylating and acylating agents give initial reaction on the endocyclic nitrogen. Acyl groups, however, readily rearrange to the exocyclic nitrogen to give the products usually observed in these reactions. These observations clear up a considerable amount of confusion in the literature and lead to the efficient synthesis of 2,3,5,6-tetrahydroimidazo[2,1-b]thiazoles.

  DOI：

  10.3987/com-94-6838
• 作为产物：
  描述：

  2-氨基-2-噻唑啉 、 3-溴丁-3-烯-2-酮 以 二氯甲烷 、 氯仿 为溶剂， 反应 72.0h， 以84%的产率得到1-(2,3,5,6-tetrahydroimidazo<2,1-b>thiazol-6-yl)ethanone
  参考文献：
  名称：

  Synthesis of 2,3,5,6-Tetrahydroimidazo[2,1-b]thiazoles

  摘要：

  The reactions of 2-amino-2-thiazoline with alkylating and acylating agents give initial reaction on the endocyclic nitrogen. Acyl groups, however, readily rearrange to the exocyclic nitrogen to give the products usually observed in these reactions. These observations clear up a considerable amount of confusion in the literature and lead to the efficient synthesis of 2,3,5,6-tetrahydroimidazo[2,1-b]thiazoles.

  DOI：

  10.3987/com-94-6838

文献信息

• Synthesis of 2,3,5,6-Tetrahydroimidazo[2,1-b]thiazoles
  作者：Girts Kaugars、Scott E. Martin、Stephen J. Nelson、William Watt

  DOI：10.3987/com-94-6838

  日期：——

  The reactions of 2-amino-2-thiazoline with alkylating and acylating agents give initial reaction on the endocyclic nitrogen. Acyl groups, however, readily rearrange to the exocyclic nitrogen to give the products usually observed in these reactions. These observations clear up a considerable amount of confusion in the literature and lead to the efficient synthesis of 2,3,5,6-tetrahydroimidazo[2,1-b]thiazoles.