(1E,2E)-1,2-bis(1-phenylbutylidene)hydrazine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (1E,2E)-1,2-bis(1-phenylbutylidene)hydrazine
• 英文别名: (1E,2E)-bis(1-phenylbutylidene)hydrazine；(E)-1-phenyl-N-[(E)-1-phenylbutylideneamino]butan-1-imine
• 化学式: C₂₀H₂₄N₂
• 分子量: 292.424
• InChiKey: STNJLWRYHDHVSK-FLFKKZLDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  24.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1E,2E)-1,2-bis(1-phenylbutylidene)hydrazine 、 氯 以82%的产率得到
  参考文献：
  名称：

  BRAUN, D.;JAKOBI, R., MONATSH. CHEM., 1982, 113, N 12, 1403-1414

  摘要：

  DOI：
• 作为产物：
  描述：

  苯丁酮 在 一水合肼 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 以56.2%的产率得到(1E,2E)-1,2-bis(1-phenylbutylidene)hydrazine
  参考文献：
  名称：

  Rhodium(III)-catalyzed coupling of aromatic ketazines or oximes with 2-vinyloxirane via C–H activation

  摘要：

  Described herein is a rhodium(III)-catalyzed coupling of aromatic ketazines or oximes with 2-vinyloxirane via directed C-H activation. This reaction proceeds efficiently under mild conditions with a low catalyst loading, especially in conditions with room temperature in the absence of additives for aromatic ketazines. A wide range of substituted substrates is supported and a possible mechanism is proposed according to the experimental results of kinetic isotopic effect, reversibility studies, and catalysis with rhodacycle intermediate c1. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.08.025

文献信息

• Ruthenium(<scp>ii</scp>)-catalysed direct synthesis of ketazines using secondary alcohols
  作者：Jugal Kishore、Subramanian Thiyagarajan、Chidambaram Gunanathan

  DOI：10.1039/c9cc01383k

  日期：——

  Direct one-pot synthesis of ketazines from secondary alcohols and hydrazine hydrate catalyzed by a ruthenium pincer complex is reported, which proceeds through O–H bond activation of secondary alcohols via amine–amide metal–ligand cooperation in the catalyst. Remarkably, liberated molecular hydrogen and water are the only byproducts.

  据报道，由钌夹钳络合物催化仲醇直接从仲醇和水合肼中直接合成氯胺酮，该过程是通过仲醇通过胺-酰胺金属-配体在催化剂中的协同作用进行O-H键活化而进行的。值得注意的是，释放出的分子氢和水是唯一的副产物。
• GRADBERG I. I.; YAKUSHCHENKO I. K.; DMITRIEV L. B., ZH. ORGAN. XIMII, 1979, 15, HO 1, 89-95
  作者：GRADBERG I. I.、 YAKUSHCHENKO I. K.、 DMITRIEV L. B.

  DOI：——

  日期：——
• Rhodium(III)-catalyzed coupling of aromatic ketazines or oximes with 2-vinyloxirane via C–H activation
  作者：Jing Wen、An Wu、Yuqin Miao、Jin Zhu

  DOI：10.1016/j.tetlet.2015.08.025

  日期：2015.10

  Described herein is a rhodium(III)-catalyzed coupling of aromatic ketazines or oximes with 2-vinyloxirane via directed C-H activation. This reaction proceeds efficiently under mild conditions with a low catalyst loading, especially in conditions with room temperature in the absence of additives for aromatic ketazines. A wide range of substituted substrates is supported and a possible mechanism is proposed according to the experimental results of kinetic isotopic effect, reversibility studies, and catalysis with rhodacycle intermediate c1. (C) 2015 Elsevier Ltd. All rights reserved.
• BRAUN, D.;JAKOBI, R., MONATSH. CHEM., 1982, 113, N 12, 1403-1414
  作者：BRAUN, D.、JAKOBI, R.

  DOI：——

  日期：——