N¹,N¹-diisopropyl-N²-(diphenylphosphoryl)-2-[N-(1,1-dimethylethoxy)carbonyl-N-phenyl]aminoacetamidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N¹,N¹-diisopropyl-N²-(diphenylphosphoryl)-2-[N-(1,1-dimethylethoxy)carbonyl-N-phenyl]aminoacetamidine
• 英文别名: tert-butyl N-[(2Z)-2-diphenoxyphosphorylimino-2-[di(propan-2-yl)amino]ethyl]-N-phenylcarbamate
• 化学式: C₃₁H₄₀N₃O₅P
• 分子量: 565.649
• InChiKey: QUVCMUWXZGTFAF-OVXWJCGASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  40
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  80.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  叔丁基乙炔基(苯基)氨基甲酸酯 、 叠氮磷酸二苯酯 、 二异丙胺 在 copper(l) iodide 作用下， 以 氯仿 为溶剂， 反应 6.0h， 以90%的产率得到N¹,N¹-diisopropyl-N²-(diphenylphosphoryl)-2-[N-(1,1-dimethylethoxy)carbonyl-N-phenyl]aminoacetamidine
  参考文献：
  名称：

  Highly efficient synthesis of α-amino amidines from ynamides by the Cu-catalyzed three-component coupling reactions

  摘要：

  Using ynamides as one of the reacting components, the Cu-catalyzed three-component reaction of sulfonyl or phosphoryl azides and amines affords alpha-amino amidines in high yields under mild conditions. Synthetic utility of the produced compounds was demonstrated in the diastereoselective alkylation of alpha-amino amidines bearing a chiral oxazolidinone moiety. It was also shown that alpha-amino imidates could be readily prepared by employing alcohols instead of amines. (c) 2008 Elsevier Ltd. Ail rights reserved.

  DOI：

  10.1016/j.tetlet.2008.01.073

文献信息

• Highly efficient synthesis of α-amino amidines from ynamides by the Cu-catalyzed three-component coupling reactions
  作者：Ji Young Kim、Seok Hwan Kim、Sukbok Chang

  DOI：10.1016/j.tetlet.2008.01.073

  日期：2008.3

  Using ynamides as one of the reacting components, the Cu-catalyzed three-component reaction of sulfonyl or phosphoryl azides and amines affords alpha-amino amidines in high yields under mild conditions. Synthetic utility of the produced compounds was demonstrated in the diastereoselective alkylation of alpha-amino amidines bearing a chiral oxazolidinone moiety. It was also shown that alpha-amino imidates could be readily prepared by employing alcohols instead of amines. (c) 2008 Elsevier Ltd. Ail rights reserved.