N-[2-benzoyl-4-(4-methyl-piperazin-1-yl)-phenyl]-2,2-dimethyl-propionamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-benzoyl-4-(4-methyl-piperazin-1-yl)-phenyl]-2,2-dimethyl-propionamide
• 英文别名: N-[2-benzoyl-4-(4-methylpiperazin-1-yl)phenyl]-2,2-dimethylpropanamide
• 化学式: C₂₃H₂₉N₃O₂
• 分子量: 379.502
• InChiKey: SFHWNISRNOGHTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  52.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-[2-benzoyl-4-(4-methyl-piperazin-1-yl)-phenyl]-2,2-dimethyl-propionamide 在 乙酸乙酯 、 二氯甲烷 、 magnesium sulfate 作用下， 以 盐酸 为溶剂， 反应 20.0h， 以to yield 245 mg (quantitative) of the product as light yellow oil的产率得到[2-amino-5-(4-methyl-piperazin-1-yl)-phenyl]-phenyl-methanone
  参考文献：
  名称：

  Phenyl substituted pyridine and benzene derivatives

  摘要：

  本发明是由苯基取代的吡啶或苯衍生物及其药学上可接受的盐所形成的一系列化合物。这些化合物已经表现出高亲和力作为NK-1受体拮抗剂。

  公开号：

  US06596773B2
• 作为产物：
  描述：

  2,2-dimethyl-N-[4-(4-methyl-piperazin-1-yl)-phenyl]1-propionamide 、 N-甲基-N-甲基苯甲酰胺 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 4.17h， 以17%的产率得到N-[2-benzoyl-4-(4-methyl-piperazin-1-yl)-phenyl]-2,2-dimethyl-propionamide
  参考文献：
  名称：

  Phenyl substituted pyridine and benzene derivatives

  摘要：

  本发明是一系列由苯基取代的吡啶或苯衍生物及其药用盐形成的化合物。这些化合物已显示出作为NK-1受体拮抗剂的高亲和力。

  公开号：

  US06407111B1

文献信息

• PHENYL- AND PYRIDINYL DERIVATIVES AS NEUROKININ 1 ANTAGONISTS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1157006A2

  公开（公告）日：2001-11-28
• US6407111B1
  申请人：——

  公开号：US6407111B1

  公开（公告）日：2002-06-18
• US6596773B2
  申请人：——

  公开号：US6596773B2

  公开（公告）日：2003-07-22
• [EN] PHENYL- AND PYRIDINYL DERIVATIVES<br/>[FR] DERIVES DE PYRIDINYL ET DE PHENYLE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2000050398A2

  公开（公告）日：2000-08-31

  The invention relates to compounds of general formula (I), wherein R is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; R1 is hydrogen or halogen; or R and R1 may be together -CH=CH-CH=CH-; R2 is hydrogen, halogen, trifluoromethyl, lower alkoxy or cyano; R3 is independently from each other hydrogen, lower alkyl or form a cycloalkyl group; R4 is hydrogen, halogen, lower alkyl, lower alkoxy, -N(R5)2, -N(R5)S(O)2-lower alkyl, -N(R?5)C(O)R5¿ or a cyclic tertiary amine of the group (a); R5 is, independently from each other, hydrogen, C¿3-6?-cycloalkyl, benzyl or lower alkyl; R?6¿ is hydrogen, hydroxy, lower alkyl, -N(R5)CO-lower alkyl, hydroxy-lower alkyl, cyano, -CHO or a 5- or 6 membered heterocyclic group, optionally bonded via an alkylene group, X is -C(O)N(R5)-, -(CH¿2?)mO-, -(CH2)mN(R?5¿)-, -N(R5) C(O)-, C(O)O- or -N(R5)(CH2)m-; Y is -(CH2)n-, -O-, -S-, SO2-, -C(O)- or -N(R5)-; Z is =N-, -CH= or -C(C1)=; n is 0 - 4; and, is 1 or 2; and to pharmaceutically acceptable acid addition salts thereof. It has been shown that the compounds of formula (I) have a high affinity to the NK-1 receptor.
• [EN] FLAME RETARDING FOAM COMPOSITION UTILIZING WASTE MATERIAL AND FABRICATING METHOD THEREOF<br/>[FR] COMPOSITION DE MOUSSE IGNIFUGE UTILISANT DES MATIERES RESIDUELLES ET SON PROCEDE DE PRODUCTION
  申请人：JO BYUNG-WOOK

  公开号：WO2003048242A1

  公开（公告）日：2003-06-12

  There is disclosed a flame retarding foam composition which uses waste polyethylene (W-PE), waste ethylene-vinyl copolymer (W-EVA), waste rubber, or ground tire rubber (GTR) as the waste material for a base resin if necessary, blends one or more ingredients out of virgin polyethylene, nitrile rubber and ethylene-propylene copolymer (EPDM) and then adds an inorganic-based and phosphorus-based flame retarding agent, foaming agent, crosslink agent or other addition agent, thereby efficiently recycling the waste plastic, the waste rubber and the ground tire rubber and, at the same time, providing products which are environment-friendly and have a high stability, mechanical and physical property, particularly, a high flame retardancy and economic efficiency.