1,4-bis[4-(1H-benzimidazol-2-yl)phenyl]piperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1,4-bis[4-(1H-benzimidazol-2-yl)phenyl]piperazine
• 英文别名: 1,4-bis[4-(1H-benzymidazol-2-yl)phenyl]piperazine dihydrochloride；2-[4-[4-[4-(1H-benzimidazol-2-yl)phenyl]piperazin-1-yl]phenyl]-1H-benzimidazole;hydrochloride
• 化学式: C₃₀H₂₆N₆*2ClH
• 分子量: 543.499
• InChiKey: JSKIPOMMYWRTKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.52
• 重原子数：
  37
• 可旋转键数：
  4
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  63.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4,4-(哌嗪-1,4-二基)二苯甲醛 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 1,4-bis[4-(1H-benzimidazol-2-yl)phenyl]piperazine
  参考文献：
  名称：

  Piperazine-linked bisbenzamidines: a novel class of antileishmanial agents

  摘要：

  A series of 13 1,4-diarylpiperazines has been prepared, evaluated for antileishmanial activity and their binding affinity to DNA was measured. Among these compounds, 1,4-bis[4-(1H-benzimidazol-2-yl)phenyl]piperazine (14) emerged as the most active compound with an IC50 value of 0.41 muM which is about sevenfold more potent than pentamidine. (C) 2004 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2004.01.009

文献信息

• Bisbenzamidines and bisbenzamidoximes for the treatment of human African trypanosomiasis
  申请人：HUANG Tien L.

  公开号：US20080139534A1

  公开（公告）日：2008-06-12

  Disclosed are bisbenzamidine and bisbenzamidoxime compounds useful for treatment of treatment of trypanosomiasis. The compounds disclosed are useful for treating mammals infected with parasitic hemoflagellates, in particular Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense.

  揭示了对治疗锥虫病有用的双苯甲酰胺和双苯甲酰肟化合物。所揭示的化合物对治疗感染寄生性血液旗ellates的哺乳动物特别有效，尤其是对于甘比亚锥虫和罗德西亚锥虫。
• Piperazine-linked bisbenzamidines: a novel class of antileishmanial agents
  作者：Annie Mayence、Jean Jacques Vanden Eynde、Louis LeCour、Larry A. Walker、Babu L. Tekwani、Tien L. Huang

  DOI：10.1016/j.ejmech.2004.01.009

  日期：2004.6

  A series of 13 1,4-diarylpiperazines has been prepared, evaluated for antileishmanial activity and their binding affinity to DNA was measured. Among these compounds, 1,4-bis[4-(1H-benzimidazol-2-yl)phenyl]piperazine (14) emerged as the most active compound with an IC50 value of 0.41 muM which is about sevenfold more potent than pentamidine. (C) 2004 Elsevier SAS. All rights reserved.