N,N′-(decane-1,10-diyl)bis(3,4,5-trimethoxybenzamide)

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N′-(decane-1,10-diyl)bis(3,4,5-trimethoxybenzamide)
• 英文别名: 3,4,5-trimethoxy-N-[10-[(3,4,5-trimethoxybenzoyl)amino]decyl]benzamide
• 化学式: C₃₀H₄₄N₂O₈
• 分子量: 560.688
• InChiKey: GOKZNYKGOWCABM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  40
• 可旋转键数：
  19
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  N,N′-(decane-1,10-diyl)bis(3,4,5-trimethoxybenzamide) 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以70%的产率得到N,N'-decamethylenebis(3,4,5-trihydroxybenzamide)
  参考文献：
  名称：

  Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors

  摘要：

  Linear and branched compounds that contain two, three or five units of galloyl (3,4,5-trihydroxybenzoyl) or its isomer 2,3,4-trihydroxybenzoyl, as well as other mono- or dihydroxybenzoyl moieties have been synthesized. These molecules have been evaluated for their in vitro inhibitory effects against a wide panel of viruses showing preferential activity against HIV and HCV.Our structure-activity relationship studies demonstrated that the 2,3,4-trihydroxybenzoyl moiety provides better antiviral activities than the galloyl (3,4,5-trihydroxybenzoyl) moiety that is present in natural green tea catechins. This observation can be of interest for the further rational exploration of compounds with anti-HCV/HIV properties.The most notable finding with respect to HIV is that the tripodal compounds 43 and 45, with three 2,3,4-trihydroxybenzoyl moieties, showed higher activities than linear compounds with only one or two. With respect to HCV, the linear compounds, 52 and 41, containing a 12 polymethylene chain and two 2,3 di- or 2,3,4 tri-hydroxybenzoyl groups respectively at the ends of the molecule showed good antiviral efficiency. Furthermore, the anti-HCV activity of both compounds was observed at concentrations well below the cytotoxicity threshold. A representative member of these compounds, 41, showed that the anti-HCV activity was largely independent of the genetic make-up of the HCV subgenomic replicon and cell lines used. (C) 2015 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2015.01.033
• 作为产物：
  描述：

  癸二胺 、 3,4,5-三甲氧基苯甲酰氯 在 potassium carbonate 作用下， 以 水 、 乙酸乙酯 为溶剂， 以65%的产率得到N,N′-(decane-1,10-diyl)bis(3,4,5-trimethoxybenzamide)
  参考文献：
  名称：

  Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors

  摘要：

  Linear and branched compounds that contain two, three or five units of galloyl (3,4,5-trihydroxybenzoyl) or its isomer 2,3,4-trihydroxybenzoyl, as well as other mono- or dihydroxybenzoyl moieties have been synthesized. These molecules have been evaluated for their in vitro inhibitory effects against a wide panel of viruses showing preferential activity against HIV and HCV.Our structure-activity relationship studies demonstrated that the 2,3,4-trihydroxybenzoyl moiety provides better antiviral activities than the galloyl (3,4,5-trihydroxybenzoyl) moiety that is present in natural green tea catechins. This observation can be of interest for the further rational exploration of compounds with anti-HCV/HIV properties.The most notable finding with respect to HIV is that the tripodal compounds 43 and 45, with three 2,3,4-trihydroxybenzoyl moieties, showed higher activities than linear compounds with only one or two. With respect to HCV, the linear compounds, 52 and 41, containing a 12 polymethylene chain and two 2,3 di- or 2,3,4 tri-hydroxybenzoyl groups respectively at the ends of the molecule showed good antiviral efficiency. Furthermore, the anti-HCV activity of both compounds was observed at concentrations well below the cytotoxicity threshold. A representative member of these compounds, 41, showed that the anti-HCV activity was largely independent of the genetic make-up of the HCV subgenomic replicon and cell lines used. (C) 2015 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2015.01.033

文献信息

• 一种小分子杂环二聚体和用途
  申请人：中国医学科学院生物医学工程研究所

  公开号：CN110229110B

  公开（公告）日：2022-07-08

  本发明公开了一种用于肿瘤治疗的小分子杂环二聚体和用途。所述的小分子杂环二聚体具有下述结构：实验证明：本发明的小分子杂环二聚体抑瘤谱广、抗肿瘤活性强，对人宫颈癌细胞HeLa、人肝癌细胞Hep G2、人乳腺癌细胞MCF‑7、人咽鳞癌细胞FaDu、人非小细胞肺癌细胞A549的IC50达到μM水平，远高于对照药物川芎嗪，而对人乳腺细胞MCF 10A的IC50高于肿瘤细胞，体现出高效低毒的特性。本发明的小分子杂环二聚体在抗肿瘤药物开发方面具有潜在的应用价值。
• Novel Homo-Bivalent and Polyvalent Compounds Based on Ligustrazine and Heterocyclic Ring as Anticancer Agents
  作者：Jiawen Wang、Ge Hong、Guoliang Li、Wenzhi Wang、Tianjun Liu

  DOI：10.3390/molecules24244505

  日期：——

  Bivalent and polyvalent inhibitors can be used as antitumor agents. In this experiment, eight ligustrazine dimers and seven ligustrazine tetramers linked by alkane diamine with different lengths of carbon chain lengths were synthesized. After screening their antiproliferation activities against five cancer cell lines, most ligustrazine derivatives showed better cytotoxicity than the ligustrazine monomer

  二价和多价抑制剂可用作抗肿瘤剂。本实验合成了8个川芎嗪二聚体和7个由不同碳链长度的烷二胺连接的川芎嗪四聚体。在筛选了它们对五种癌细胞系的抗增殖活性后，大多数川芎嗪衍生物显示出比川芎嗪单体更好的细胞毒性。特别是，与癸烷-1,10-二胺相连的川芎嗪二聚体 8e 在 FaDu 细胞中表现出最高的细胞毒性，IC50（50% 抑制浓度）值为 1.36 nM。进一步的机制研究表明，8e 可以通过线粒体膜电位的去极化和 S 期细胞周期阻滞诱导 FaDu 细胞凋亡。受这些结果的启发，合成并筛选了另外 27 个与癸烷-1,10-二胺相连的小分子杂环二聚体和 9 个带有醚链的肉桂酸二聚体。大多数单环和双环芳香系统对 FaDu 细胞显示出高度选择性的抗增殖活性，对正常 MCF 10A 细胞显示出低毒性。构效关系表明，两个末端酰胺键和链长为 8-12 个碳的烷基接头是维持其抗肿瘤活性的两个重要因素。此外，ADMET