N-cyclopropyl-4-methyl-3-(4-phenyl-pyrazolo[3,4-d]pyrimidin-1-yl)benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-cyclopropyl-4-methyl-3-(4-phenyl-pyrazolo[3,4-d]pyrimidin-1-yl)benzamide
• 英文别名: N-Cyclopropyl-4-methyl-3-(4-phenyl-pyrazolo[3,4-d]pyrimidin-1-yl)-benzamide；N-cyclopropyl-4-methyl-3-(4-phenylpyrazolo[3,4-d]pyrimidin-1-yl)benzamide
• 化学式: C₂₂H₁₉N₅O
• 分子量: 369.426
• InChiKey: SIBMTIZCNOKSAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  72.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-(5-amino-4-benzoyl-pyrazol-1-yl)-N-cyclopropyl-4-methyl-benzamide 、 formamide 在 溶剂黄146 作用下， 反应 0.33h， 以62%的产率得到N-cyclopropyl-4-methyl-3-(4-phenyl-pyrazolo[3,4-d]pyrimidin-1-yl)benzamide
  参考文献：
  名称：

  [EN] BICYCLIC HETEROCYCLIC P-38 KINASE INHIBITORS
  [FR] INHIBITEURS HETEROCYCLIQUES BICYCLIQUES DES KINASES P-38

  摘要：

  公开号：

  WO2005063766A3

文献信息

• Bicyclic heterocyclic p-38 kinase inhibitors
  申请人：Dong Qing

  公开号：US20070142405A1

  公开（公告）日：2007-06-21

  Provided are bicyclic heterocycle-based p38 kinase, including p38α and p38β kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.

  提供了基于双环杂环的p38激酶抑制剂，包括p38α和p38β激酶。还提供了含有这些化合物的药物组合物。还提供了这些化合物和组合物的使用方法，包括治疗、预防或缓解p38激酶介导的疾病和疾病的一种或多种症状，包括但不限于炎症性疾病和疾病。
• Bicyclic Heterocyclic p-38 Kinase Inhibitors
  申请人：Dong Qing

  公开号：US20090264409A1

  公开（公告）日：2009-10-22

  Provided are bicyclic heterocycle-based p38 kinase, including p38α and p38β kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.

  提供了基于双环杂环的p38激酶抑制剂，包括p38α和p38β激酶。还提供了含有这些化合物的制药组合物。还提供了使用这些化合物和组合物的方法，包括治疗、预防或改善p38激酶介导的疾病和疾病的一个或多个症状的方法，包括但不限于炎症性疾病和疾病。
• Substituted pyrazolo [3,4-d]pyrimidines as cytokine modulators
  申请人：Novartis AG

  公开号：US07569571B2

  公开（公告）日：2009-08-04

  Provided are bicyclic heterocycle-based p38 kinase, including p38α and p38β kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.

  提供了基于双环杂环的p38激酶抑制剂，包括p38α和p38β激酶。还提供了含有这些化合物的药物组合物。还提供了这些化合物和组合物的使用方法，包括治疗、预防或改善p38激酶介导的疾病和疾病的一个或多个症状的方法，包括但不限于炎症性疾病和疾病。
• [EN] BICYCLIC HETEROCYCLIC P-38 KINASE INHIBITORS<br/>[FR] INHIBITEURS HETEROCYCLIQUES BICYCLIQUES DES KINASES P-38
  申请人：NOVARTIS PHARMA AG

  公开号：WO2005063766A3

  公开（公告）日：2005-09-09
• BICYCLIC HETEROCYCLIC P-38 KINASE INHIBITORS
  申请人：Novartis AG

  公开号：EP1699800B1

  公开（公告）日：2010-02-10