(3R)-3-(3,4-dichlorophenyl)morpholine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (3R)-3-(3,4-dichlorophenyl)morpholine
• 化学式: C₁₀H₁₁Cl₂NO
• 分子量: 232.1
• InChiKey: QVGKCGJIANUXGF-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• CYCLIC TREX1 INHIBITORS
  申请人：Venenum Biodesign, LLC

  公开号：US20210015829A1

  公开（公告）日：2021-01-21

  The present invention provides compounds of Formula I: wherein X, R 1 , R 2 , R 3 and R 4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are effective at modulating the TREX1 protein and thus can be used as medicaments for treating or preventing disorders affected by the inhibition of TREX1.